UniProtKB - H9GF43 (H9GF43_ANOCA)
Protein
Hyaluronan synthase 2
Gene
has2
Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Functioni
Catalytic activityi
- N-acetyl-β-D-glucosaminyl-(1→4)-[hyaluronan](n) + UDP-α-D-glucuronate = [hyaluronan](n+1) + H+ + UDPARBA annotationEC:2.4.1.212ARBA annotation
- [hyaluronan](n) + UDP-N-acetyl-α-D-glucosamine = H+ + N-acetyl-β-D-glucosaminyl-(1→4)-[hyaluronan](n) + UDPARBA annotationEC:2.4.1.212ARBA annotation
Cofactori
Mg2+ARBA annotation
: hyaluronan biosynthesis Pathwayi
This protein is involved in the pathway hyaluronan biosynthesis, which is part of Glycan biosynthesis.ARBA annotationView all proteins of this organism that are known to be involved in the pathway hyaluronan biosynthesis and in Glycan biosynthesis.
GO - Molecular functioni
- hyaluronan synthase activity Source: GO_Central
GO - Biological processi
- extracellular matrix assembly Source: GO_Central
- extracellular polysaccharide biosynthetic process Source: GO_Central
- hyaluronan biosynthetic process Source: GO_Central
Enzyme and pathway databases
UniPathwayi | UPA00341 |
Names & Taxonomyi
Protein namesi | Recommended name: Hyaluronan synthase 2ARBA annotation (EC:2.4.1.212ARBA annotation)Alternative name(s): Hyaluronate synthase 2ARBA annotation Hyaluronic acid synthase 2ARBA annotation |
Gene namesi | Name:has2Imported |
Organismi | Anolis carolinensis (Green anole) (American chameleon)Imported |
Taxonomic identifieri | 28377 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Iguania › Dactyloidae › Anolis |
Proteomesi |
|
Subcellular locationi
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 7 – 32 | HelicalSequence analysisAdd BLAST | 26 | |
Transmembranei | 44 – 67 | HelicalSequence analysisAdd BLAST | 24 | |
Transmembranei | 376 – 398 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 432 – 456 | HelicalSequence analysisAdd BLAST | 25 | |
Transmembranei | 476 – 498 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 510 – 534 | HelicalSequence analysisAdd BLAST | 25 |
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | ENSACAG00000009367, Expressed in embryonic post-anal tail and 6 other tissues |
Family & Domainsi
Sequence similaritiesi
Belongs to the NodC/HAS family.ARBA annotation
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
eggNOGi | KOG2571, Eukaryota |
GeneTreei | ENSGT00390000010337 |
HOGENOMi | CLU_029695_3_0_1 |
InParanoidi | H9GF43 |
OrthoDBi | 332363at2759 |
TreeFami | TF332506 |
Family and domain databases
InterProi | View protein in InterPro IPR028371, HAS2 IPR029044, Nucleotide-diphossugar_trans |
PANTHERi | PTHR22913:SF7, PTHR22913:SF7, 1 hit |
SUPFAMi | SSF53448, SSF53448, 1 hit |
i Sequence
Sequence statusi: Complete.
H9GF43-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MMHCERFICI LRILGTTLFG VSLLLGISAA YIVGYQFIQT DNYYFSFGLY
60 70 80 90 100
GAILASHLII QSLFAFLEHR KMKRSLETPI KLNKTVALCI AAYQEDPDYL
110 120 130 140 150
RKCLLSVKRL TYPGIKVIMV IDGNSEDDVY MMDIFTEIMG RDRSATYIWR
160 170 180 190 200
NNFHQRGPDE SDESHKESMQ HVTQLVLSNK SVCIMQKWGG KREVMYTAFK
210 220 230 240 250
ALGRSVDYVQ VCDSDTMLDP ASSVEMVKVL EEDPMVGGVG GDVQILNKYD
260 270 280 290 300
SWISFLSSVR YWMAFNIERA CQSYFGCVQC ISGPLGMYRN SLLHEFVEDW
310 320 330 340 350
YNQEFMGSQC SFGDDRHLTN RVLSLGYATK YTARSKCLTE TPIEYLRWLN
360 370 380 390 400
QQTRWSKSYF REWLYNAMWF HKHHLWMTYE AVITGFFPFF LIATVIQLFY
410 420 430 440 450
RGKLWNILLF LLTVQLVGLI KSSFASCLRG NIVMVFMSLY SVLYMSSLLP
460 470 480 490 500
AKMFAIATIN KAGWGTSGRK TIVVNFIGLI PVSVWFTILL GGVIFTVYKE
510 520 530 540 550
SKKPFSESKQ TVLIIGTILY ACYWVMLLTL YLVLITKCGR RKKEQQYDMV
LDV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAWZ02022731 Genomic DNA No translation available. AAWZ02022732 Genomic DNA No translation available. AAWZ02022733 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENSACAT00000009373; ENSACAP00000009180; ENSACAG00000009367 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAWZ02022731 Genomic DNA No translation available. AAWZ02022732 Genomic DNA No translation available. AAWZ02022733 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000009180 |
Genome annotation databases
Ensembli | ENSACAT00000009373; ENSACAP00000009180; ENSACAG00000009367 |
Phylogenomic databases
eggNOGi | KOG2571, Eukaryota |
GeneTreei | ENSGT00390000010337 |
HOGENOMi | CLU_029695_3_0_1 |
InParanoidi | H9GF43 |
OrthoDBi | 332363at2759 |
TreeFami | TF332506 |
Enzyme and pathway databases
UniPathwayi | UPA00341 |
Gene expression databases
Bgeei | ENSACAG00000009367, Expressed in embryonic post-anal tail and 6 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR028371, HAS2 IPR029044, Nucleotide-diphossugar_trans |
PANTHERi | PTHR22913:SF7, PTHR22913:SF7, 1 hit |
SUPFAMi | SSF53448, SSF53448, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | H9GF43_ANOCA | |
Accessioni | H9GF43Primary (citable) accession number: H9GF43 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 16, 2012 |
Last sequence update: | June 26, 2013 | |
Last modified: | August 12, 2020 | |
This is version 47 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |