UniProtKB - H9GEA7 (H9GEA7_ANOCA)
Protein
HMG box domain-containing protein
Gene
SOX9
Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 122 – 190 | HMG boxPROSITE-ProRule annotationAdd BLAST | 69 |
GO - Molecular functioni
- beta-catenin binding Source: Ensembl
- chromatin binding Source: Ensembl
- cis-regulatory region sequence-specific DNA binding Source: GO_Central
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: GO_Central
- pre-mRNA intronic binding Source: Ensembl
- protein kinase A catalytic subunit binding Source: Ensembl
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: Ensembl
GO - Biological processi
- anterior head development Source: Ensembl
- aortic valve morphogenesis Source: Ensembl
- astrocyte fate commitment Source: Ensembl
- branching involved in ureteric bud morphogenesis Source: Ensembl
- bronchus cartilage development Source: Ensembl
- cAMP-mediated signaling Source: Ensembl
- cartilage condensation Source: Ensembl
- cell-cell adhesion Source: Ensembl
- cell fate specification Source: Ensembl
- cellular response to epidermal growth factor stimulus Source: Ensembl
- cellular response to heparin Source: Ensembl
- cellular response to interleukin-1 Source: Ensembl
- cellular response to mechanical stimulus Source: Ensembl
- cellular response to retinoic acid Source: Ensembl
- cellular response to transforming growth factor beta stimulus Source: Ensembl
- central nervous system development Source: GO_Central
- chondrocyte differentiation Source: GO_Central
- chromatin remodeling Source: Ensembl
- cochlea morphogenesis Source: Ensembl
- cytoskeleton organization Source: Ensembl
- endocardial cushion morphogenesis Source: Ensembl
- endocrine pancreas development Source: Ensembl
- epidermal growth factor receptor signaling pathway Source: Ensembl
- epithelial cell proliferation involved in prostatic bud elongation Source: Ensembl
- epithelial to mesenchymal transition Source: Ensembl
- epithelial tube branching involved in lung morphogenesis Source: Ensembl
- ERK1 and ERK2 cascade Source: Ensembl
- extracellular matrix organization Source: Ensembl
- growth plate cartilage chondrocyte growth Source: Ensembl
- Harderian gland development Source: Ensembl
- heart development Source: GO_Central
- heart valve formation Source: Ensembl
- intestinal epithelial structure maintenance Source: Ensembl
- intrahepatic bile duct development Source: Ensembl
- lacrimal gland development Source: Ensembl
- limb bud formation Source: Ensembl
- lung epithelial cell differentiation Source: Ensembl
- lung smooth muscle development Source: Ensembl
- male germ-line sex determination Source: Ensembl
- metanephric nephron tubule formation Source: Ensembl
- morphogenesis of an epithelium Source: GO_Central
- negative regulation of beta-catenin-TCF complex assembly Source: Ensembl
- negative regulation of bone mineralization Source: Ensembl
- negative regulation of canonical Wnt signaling pathway Source: Ensembl
- negative regulation of chondrocyte differentiation Source: Ensembl
- negative regulation of epithelial cell differentiation Source: Ensembl
- negative regulation of epithelial cell proliferation Source: Ensembl
- negative regulation of fatty acid oxidation Source: Ensembl
- negative regulation of immune system process Source: Ensembl
- negative regulation of mesenchymal cell apoptotic process Source: Ensembl
- negative regulation of myoblast differentiation Source: Ensembl
- negative regulation of osteoblast differentiation Source: Ensembl
- negative regulation of photoreceptor cell differentiation Source: Ensembl
- negative regulation of pri-miRNA transcription by RNA polymerase II Source: Ensembl
- negative regulation of transcription by RNA polymerase II Source: GO_Central
- neural crest cell development Source: Ensembl
- Notch signaling pathway Source: Ensembl
- notochord development Source: Ensembl
- nucleosome assembly Source: Ensembl
- oligodendrocyte differentiation Source: GO_Central
- ossification Source: Ensembl
- otic vesicle formation Source: Ensembl
- positive regulation of branching involved in ureteric bud morphogenesis Source: Ensembl
- positive regulation of cell proliferation involved in heart morphogenesis Source: Ensembl
- positive regulation of chondrocyte differentiation Source: GO_Central
- positive regulation of chondrocyte proliferation Source: Ensembl
- positive regulation of epithelial cell differentiation Source: Ensembl
- positive regulation of epithelial cell migration Source: Ensembl
- positive regulation of epithelial cell proliferation Source: Ensembl
- positive regulation of extracellular matrix assembly Source: Ensembl
- positive regulation of male gonad development Source: Ensembl
- positive regulation of mesenchymal cell proliferation Source: Ensembl
- positive regulation of mesenchymal stem cell differentiation Source: Ensembl
- positive regulation of phosphatidylinositol 3-kinase signaling Source: Ensembl
- positive regulation of protein catabolic process Source: Ensembl
- positive regulation of protein phosphorylation Source: Ensembl
- positive regulation of transcription by RNA polymerase II Source: GO_Central
- protein kinase B signaling Source: Ensembl
- protein localization to nucleus Source: Ensembl
- regulation of branching involved in lung morphogenesis Source: Ensembl
- regulation of cell adhesion Source: Ensembl
- regulation of cell cycle process Source: Ensembl
- regulation of cell proliferation involved in tissue homeostasis Source: Ensembl
- regulation of epithelial cell proliferation involved in lung morphogenesis Source: Ensembl
- renal vesicle induction Source: Ensembl
- response to fatty acid Source: Ensembl
- retinal rod cell differentiation Source: Ensembl
- Sertoli cell development Source: Ensembl
- somatic stem cell population maintenance Source: Ensembl
- spermatogenesis Source: Ensembl
- trachea cartilage development Source: Ensembl
- ureter morphogenesis Source: Ensembl
- ureter smooth muscle cell differentiation Source: Ensembl
- ureter urothelium development Source: Ensembl
Keywordsi
Molecular function | DNA-bindingPROSITE-ProRule annotation |
Names & Taxonomyi
Protein namesi | Recommended name: HMG box domain-containing proteinInterPro annotation |
Gene namesi | Name:SOX9Imported |
Organismi | Anolis carolinensis (Green anole) (American chameleon)Imported |
Taxonomic identifieri | 28377 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Iguania › Dactyloidae › Anolis |
Proteomesi |
|
Subcellular locationi
Nucleus
- Nucleus ARBA annotation
Nucleus
- nucleoplasm Source: Ensembl
- nucleus Source: GO_Central
Other locations
- transcription regulator complex Source: Ensembl
Keywords - Cellular componenti
NucleusPROSITE-ProRule annotationExpressioni
Gene expression databases
Bgeei | ENSACAG00000008719, Expressed in embryo and 15 other tissues |
Interactioni
GO - Molecular functioni
- beta-catenin binding Source: Ensembl
- protein kinase A catalytic subunit binding Source: Ensembl
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000008573 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 122 – 190 | HMG boxInterPro annotationAdd BLAST | 69 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 84 | DisorderedSequence analysisAdd BLAST | 84 | |
Regioni | 177 – 291 | DisorderedSequence analysisAdd BLAST | 115 | |
Regioni | 313 – 427 | DisorderedSequence analysisAdd BLAST | 115 | |
Regioni | 485 – 517 | DisorderedSequence analysisAdd BLAST | 33 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 19 – 43 | PolarSequence analysisAdd BLAST | 25 | |
Compositional biasi | 177 – 204 | PolyampholyteSequence analysisAdd BLAST | 28 | |
Compositional biasi | 205 – 250 | PolarSequence analysisAdd BLAST | 46 | |
Compositional biasi | 264 – 291 | PolyampholyteSequence analysisAdd BLAST | 28 | |
Compositional biasi | 330 – 360 | PolarSequence analysisAdd BLAST | 31 | |
Compositional biasi | 361 – 380 | Pro-richSequence analysisAdd BLAST | 20 | |
Compositional biasi | 381 – 427 | PolarSequence analysisAdd BLAST | 47 |
Phylogenomic databases
eggNOGi | KOG0527, Eukaryota |
GeneTreei | ENSGT00940000158269 |
HOGENOMi | CLU_031800_0_0_1 |
InParanoidi | H9GEA7 |
Family and domain databases
Gene3Di | 1.10.30.10, 1 hit |
InterProi | View protein in InterPro IPR009071, HMG_box_dom IPR036910, HMG_box_dom_sf IPR029548, SOX-9 IPR022151, Sox_N |
PANTHERi | PTHR45803:SF1, PTHR45803:SF1, 1 hit |
Pfami | View protein in Pfam PF00505, HMG_box, 1 hit PF12444, Sox_N, 1 hit |
SMARTi | View protein in SMART SM00398, HMG, 1 hit |
SUPFAMi | SSF47095, SSF47095, 1 hit |
PROSITEi | View protein in PROSITE PS50118, HMG_BOX_2, 1 hit |
i Sequence
Sequence statusi: Complete.
H9GEA7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSDEQEKALS AGAPSPALSD EEASSSGSPC PSGSGSDAEG SGSSSHGGRP
60 70 80 90 100
PRLGDGGAFA KSGDAEMKKE AGGVGGGGGG GEEDKFPVCI REAVSQVLKG
110 120 130 140 150
YDWTLVPMPV RVNGASKNKP HVKRPMNAFM VWAQAARRSW PDQYPHLHNA
160 170 180 190 200
ELSKTLGKLW RLLNESEKRP FVEEAERLRV QHKKDHPDYK YQPRRRKSVK
210 220 230 240 250
NGQAEQEEGS EQTHISPNAI FKALQADSPQ SSSSMSEVHS PGEHSGQSQG
260 270 280 290 300
PPTPPTTPKT DVQTGKQDLK REGRPLQEGG RQPPHIDFRD VDIGELSSDV
310 320 330 340 350
ISNIETFDVN EFDQYLPPNG HPGVPATHGQ PGQVTYTGSY GISSTTATPT
360 370 380 390 400
GPGHVWMSKQ PPTQQPPPSS QPPPSQAQQP PQPQAHTLTT LSSEPGQPPQ
410 420 430 440 450
QRTHIKTEQL SPSHYSEQQQ HSPQQMSYSS FNLQHYGSSY PTITRSQYDY
460 470 480 490 500
TDHQSSNSYY SHAASQGSGL YSTFTYMNPT QRPMYTPIAD TTGVPSIPQT
510
HSPQHWEQPV YTQLTRP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAWZ02022271 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENSACAT00000008756; ENSACAP00000008573; ENSACAG00000008719 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAWZ02022271 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000008573 |
Genome annotation databases
Ensembli | ENSACAT00000008756; ENSACAP00000008573; ENSACAG00000008719 |
Phylogenomic databases
eggNOGi | KOG0527, Eukaryota |
GeneTreei | ENSGT00940000158269 |
HOGENOMi | CLU_031800_0_0_1 |
InParanoidi | H9GEA7 |
Gene expression databases
Bgeei | ENSACAG00000008719, Expressed in embryo and 15 other tissues |
Family and domain databases
Gene3Di | 1.10.30.10, 1 hit |
InterProi | View protein in InterPro IPR009071, HMG_box_dom IPR036910, HMG_box_dom_sf IPR029548, SOX-9 IPR022151, Sox_N |
PANTHERi | PTHR45803:SF1, PTHR45803:SF1, 1 hit |
Pfami | View protein in Pfam PF00505, HMG_box, 1 hit PF12444, Sox_N, 1 hit |
SMARTi | View protein in SMART SM00398, HMG, 1 hit |
SUPFAMi | SSF47095, SSF47095, 1 hit |
PROSITEi | View protein in PROSITE PS50118, HMG_BOX_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | H9GEA7_ANOCA | |
Accessioni | H9GEA7Primary (citable) accession number: H9GEA7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 16, 2012 |
Last sequence update: | June 26, 2013 | |
Last modified: | December 2, 2020 | |
This is version 58 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |