HMG box domain-containing protein

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• beta-catenin binding Source: Ensembl
• chromatin binding Source: Ensembl
• cis-regulatory region sequence-specific DNA binding Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription activator activity, RNA polymerase II-specific Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• pre-mRNA intronic binding Source: Ensembl
• protein kinase A catalytic subunit binding Source: Ensembl
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: Ensembl

GO - Biological processⁱ

• anterior head development Source: Ensembl
• aortic valve morphogenesis Source: Ensembl
• astrocyte fate commitment Source: Ensembl
• branching involved in ureteric bud morphogenesis Source: Ensembl
• bronchus cartilage development Source: Ensembl
• cAMP-mediated signaling Source: Ensembl
• cartilage condensation Source: Ensembl
• cell-cell adhesion Source: Ensembl
• cell fate specification Source: Ensembl
• cellular response to epidermal growth factor stimulus Source: Ensembl
• cellular response to heparin Source: Ensembl
• cellular response to interleukin-1 Source: Ensembl
• cellular response to mechanical stimulus Source: Ensembl
• cellular response to retinoic acid Source: Ensembl
• cellular response to transforming growth factor beta stimulus Source: Ensembl
• central nervous system development Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• chondrocyte differentiation Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• chromatin remodeling Source: Ensembl
• cochlea morphogenesis Source: Ensembl
• cytoskeleton organization Source: Ensembl
• endocardial cushion morphogenesis Source: Ensembl
• endocrine pancreas development Source: Ensembl
• epidermal growth factor receptor signaling pathway Source: Ensembl
• epithelial cell proliferation involved in prostatic bud elongation Source: Ensembl
• epithelial to mesenchymal transition Source: Ensembl
• epithelial tube branching involved in lung morphogenesis Source: Ensembl
• ERK1 and ERK2 cascade Source: Ensembl
• extracellular matrix organization Source: Ensembl
• growth plate cartilage chondrocyte growth Source: Ensembl
• Harderian gland development Source: Ensembl
• heart development Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• heart valve formation Source: Ensembl
• intestinal epithelial structure maintenance Source: Ensembl
• intrahepatic bile duct development Source: Ensembl
• lacrimal gland development Source: Ensembl
• limb bud formation Source: Ensembl
• lung epithelial cell differentiation Source: Ensembl
• lung smooth muscle development Source: Ensembl
• male germ-line sex determination Source: Ensembl
• metanephric nephron tubule formation Source: Ensembl
• morphogenesis of an epithelium Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• negative regulation of beta-catenin-TCF complex assembly Source: Ensembl
• negative regulation of bone mineralization Source: Ensembl
• negative regulation of canonical Wnt signaling pathway Source: Ensembl
• negative regulation of chondrocyte differentiation Source: Ensembl
• negative regulation of epithelial cell differentiation Source: Ensembl
• negative regulation of epithelial cell proliferation Source: Ensembl
• negative regulation of fatty acid oxidation Source: Ensembl
• negative regulation of immune system process Source: Ensembl
• negative regulation of mesenchymal cell apoptotic process Source: Ensembl
• negative regulation of myoblast differentiation Source: Ensembl
• negative regulation of osteoblast differentiation Source: Ensembl
• negative regulation of photoreceptor cell differentiation Source: Ensembl
• negative regulation of pri-miRNA transcription by RNA polymerase II Source: Ensembl
• negative regulation of transcription by RNA polymerase II Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• neural crest cell development Source: Ensembl
• Notch signaling pathway Source: Ensembl
• notochord development Source: Ensembl
• nucleosome assembly Source: Ensembl
• oligodendrocyte differentiation Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• ossification Source: Ensembl
• otic vesicle formation Source: Ensembl
• positive regulation of branching involved in ureteric bud morphogenesis Source: Ensembl
• positive regulation of cell proliferation involved in heart morphogenesis Source: Ensembl
• positive regulation of chondrocyte differentiation Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• positive regulation of chondrocyte proliferation Source: Ensembl
• positive regulation of epithelial cell differentiation Source: Ensembl
• positive regulation of epithelial cell migration Source: Ensembl
• positive regulation of epithelial cell proliferation Source: Ensembl
• positive regulation of extracellular matrix assembly Source: Ensembl
• positive regulation of male gonad development Source: Ensembl
• positive regulation of mesenchymal cell proliferation Source: Ensembl
• positive regulation of mesenchymal stem cell differentiation Source: Ensembl
• positive regulation of phosphatidylinositol 3-kinase signaling Source: Ensembl
• positive regulation of protein catabolic process Source: Ensembl
• positive regulation of protein phosphorylation Source: Ensembl
• positive regulation of transcription by RNA polymerase II Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• protein kinase B signaling Source: Ensembl
• protein localization to nucleus Source: Ensembl
• regulation of branching involved in lung morphogenesis Source: Ensembl
• regulation of cell adhesion Source: Ensembl
• regulation of cell cycle process Source: Ensembl
• regulation of cell proliferation involved in tissue homeostasis Source: Ensembl
• regulation of epithelial cell proliferation involved in lung morphogenesis Source: Ensembl
• renal vesicle induction Source: Ensembl
• response to fatty acid Source: Ensembl
• retinal rod cell differentiation Source: Ensembl
• Sertoli cell development Source: Ensembl
• somatic stem cell population maintenance Source: Ensembl
• spermatogenesis Source: Ensembl
• trachea cartilage development Source: Ensembl
• ureter morphogenesis Source: Ensembl
• ureter smooth muscle cell differentiation Source: Ensembl
• ureter urothelium development Source: Ensembl

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Keywords - PTMⁱ

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• beta-catenin binding Source: Ensembl
• protein kinase A catalytic subunit binding Source: Ensembl

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Compositional bias

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MSDEQEKALS AGAPSPALSD EEASSSGSPC PSGSGSDAEG SGSSSHGGRP 
        60         70         80         90        100
PRLGDGGAFA KSGDAEMKKE AGGVGGGGGG GEEDKFPVCI REAVSQVLKG 
       110        120        130        140        150
YDWTLVPMPV RVNGASKNKP HVKRPMNAFM VWAQAARRSW PDQYPHLHNA 
       160        170        180        190        200
ELSKTLGKLW RLLNESEKRP FVEEAERLRV QHKKDHPDYK YQPRRRKSVK 
       210        220        230        240        250
NGQAEQEEGS EQTHISPNAI FKALQADSPQ SSSSMSEVHS PGEHSGQSQG 
       260        270        280        290        300
PPTPPTTPKT DVQTGKQDLK REGRPLQEGG RQPPHIDFRD VDIGELSSDV 
       310        320        330        340        350
ISNIETFDVN EFDQYLPPNG HPGVPATHGQ PGQVTYTGSY GISSTTATPT 
       360        370        380        390        400
GPGHVWMSKQ PPTQQPPPSS QPPPSQAQQP PQPQAHTLTT LSSEPGQPPQ 
       410        420        430        440        450
QRTHIKTEQL SPSHYSEQQQ HSPQQMSYSS FNLQHYGSSY PTITRSQYDY 
       460        470        480        490        500
TDHQSSNSYY SHAASQGSGL YSTFTYMNPT QRPMYTPIAD TTGVPSIPQT 
       510 
HSPQHWEQPV YTQLTRP                                     

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Genome annotation databases

Phylogenomic databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ