UniProtKB - H9GEA0 (H9GEA0_ANOCA)
Protein
MBD domain-containing protein
Gene
MBD2
Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Functioni
GO - Molecular functioni
- C2H2 zinc finger domain binding Source: Ensembl
- chromatin binding Source: Ensembl
- methyl-CpG binding Source: Ensembl
- mRNA binding Source: Ensembl
- siRNA binding Source: Ensembl
GO - Biological processi
- cellular protein-containing complex assembly Source: Ensembl
- DNA methylation-dependent heterochromatin assembly Source: Ensembl
- maternal behavior Source: Ensembl
- negative regulation of transcription by RNA polymerase II Source: Ensembl
- positive regulation of Wnt signaling pathway Source: Ensembl
- regulation of cell population proliferation Source: Ensembl
Names & Taxonomyi
Protein namesi | Recommended name: MBD domain-containing proteinInterPro annotation |
Gene namesi | Name:MBD2Imported |
Organismi | Anolis carolinensis (Green anole) (American chameleon)Imported |
Taxonomic identifieri | 28377 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Iguania › Dactyloidae › Anolis |
Proteomesi |
|
Subcellular locationi
Cytosol
- cytosol Source: Ensembl
Nucleus
- NuRD complex Source: InterPro
Other locations
- heterochromatin Source: Ensembl
Keywords - Cellular componenti
NucleusARBA annotationExpressioni
Gene expression databases
Bgeei | ENSACAG00000008739, Expressed in lung and 14 other tissues |
Interactioni
GO - Molecular functioni
- C2H2 zinc finger domain binding Source: Ensembl
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000008553 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 3 – 71 | MBDInterPro annotationAdd BLAST | 69 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 70 – 99 | DisorderedSequence analysisAdd BLAST | 30 | |
Regioni | 250 – 270 | DisorderedSequence analysisAdd BLAST | 21 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 227 – 247 | Sequence analysisAdd BLAST | 21 |
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
eggNOGi | KOG4161, Eukaryota |
GeneTreei | ENSGT00950000183005 |
HOGENOMi | CLU_069710_0_0_1 |
InParanoidi | H9GEA0 |
OrthoDBi | 1431783at2759 |
TreeFami | TF325032 |
Family and domain databases
InterProi | View protein in InterPro IPR016177, DNA-bd_dom_sf IPR032343, MBD2/MBD3_p55-bd IPR037965, MBD3 IPR025884, MeCpG-bd_2/3_C_dom IPR001739, Methyl_CpG_DNA-bd |
PANTHERi | PTHR12396:SF12, PTHR12396:SF12, 1 hit |
Pfami | View protein in Pfam PF01429, MBD, 1 hit PF14048, MBD_C, 1 hit PF16564, MBDa, 1 hit |
SMARTi | View protein in SMART SM00391, MBD, 1 hit |
SUPFAMi | SSF54171, SSF54171, 1 hit |
PROSITEi | View protein in PROSITE PS50982, MBD, 1 hit |
i Sequence
Sequence statusi: Complete.
H9GEA0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEKRGKRMDC PALPPGWKKE EVIRKSGLSA GKSDVYYFSP TGKKFRSKPQ
60 70 80 90 100
LARYLGNTVD LSSFDFRTGK MMPSKLQKNK QRLRNDSLNQ NKGKPDLNTT
110 120 130 140 150
LPIRQTASIF KQPVTKVTNH PNNKVKSDPQ RVIEQPRQLF WEKRLQGLSA
160 170 180 190 200
SDVSEQIIKS MELPKGLQGV GPGSNDNTLL SAVASALHTS SAPITGQLSA
210 220 230 240 250
AVEKNPAVWL NTSQPLCKAF IVTDEDIRKQ EERVQQVRKK LEEALMADIL
260 270
SRDADSGDLD EVEMDNGEEA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAWZ02019561 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENSACAT00000008736; ENSACAP00000008553; ENSACAG00000008739 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAWZ02019561 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000008553 |
Genome annotation databases
Ensembli | ENSACAT00000008736; ENSACAP00000008553; ENSACAG00000008739 |
Phylogenomic databases
eggNOGi | KOG4161, Eukaryota |
GeneTreei | ENSGT00950000183005 |
HOGENOMi | CLU_069710_0_0_1 |
InParanoidi | H9GEA0 |
OrthoDBi | 1431783at2759 |
TreeFami | TF325032 |
Gene expression databases
Bgeei | ENSACAG00000008739, Expressed in lung and 14 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR016177, DNA-bd_dom_sf IPR032343, MBD2/MBD3_p55-bd IPR037965, MBD3 IPR025884, MeCpG-bd_2/3_C_dom IPR001739, Methyl_CpG_DNA-bd |
PANTHERi | PTHR12396:SF12, PTHR12396:SF12, 1 hit |
Pfami | View protein in Pfam PF01429, MBD, 1 hit PF14048, MBD_C, 1 hit PF16564, MBDa, 1 hit |
SMARTi | View protein in SMART SM00391, MBD, 1 hit |
SUPFAMi | SSF54171, SSF54171, 1 hit |
PROSITEi | View protein in PROSITE PS50982, MBD, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | H9GEA0_ANOCA | |
Accessioni | H9GEA0Primary (citable) accession number: H9GEA0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 16, 2012 |
Last sequence update: | June 26, 2013 | |
Last modified: | December 2, 2020 | |
This is version 57 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |