UniProtKB - H9GDU3 (H9GDU3_ANOCA)
Protein
Receptor protein-tyrosine kinase
Gene
N/A
Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Functioni
Catalytic activityi
- EC:2.7.10.1ARBA annotation
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- transmembrane-ephrin receptor activity Source: GO_Central
- transmembrane receptor protein tyrosine kinase activity Source: GO_Central
GO - Biological processi
- axon guidance Source: GO_Central
- central nervous system projection neuron axonogenesis Source: GO_Central
- multicellular organism development Source: GO_Central
- positive regulation of kinase activity Source: GO_Central
- transmembrane receptor protein tyrosine kinase signaling pathway Source: GO_Central
Keywordsi
Molecular function | Kinase, ReceptorARBA annotation, Transferase, Tyrosine-protein kinaseARBA annotation |
Ligand | ATP-bindingARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | |
Organismi | Anolis carolinensis (Green anole) (American chameleon)Imported |
Taxonomic identifieri | 28377 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Iguania › Dactyloidae › Anolis |
Proteomesi |
|
Subcellular locationi
Other locations
- Membrane ARBA annotation; Single-pass type I membrane protein ARBA annotation
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
Other locations
- neuron projection Source: GO_Central
- receptor complex Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 273 – 295 | HelicalSequence analysisAdd BLAST | 23 |
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | ENSACAG00000008140, Expressed in embryo and 6 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 54 – 164 | Fibronectin type-IIIInterPro annotationAdd BLAST | 111 | |
Domaini | 165 – 260 | Fibronectin type-IIIInterPro annotationAdd BLAST | 96 | |
Domaini | 367 – 630 | Protein kinaseInterPro annotationAdd BLAST | 264 | |
Domaini | 659 – 697 | SAMInterPro annotationAdd BLAST | 39 |
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
eggNOGi | KOG0196, Eukaryota |
GeneTreei | ENSGT00940000155503 |
HOGENOMi | CLU_000288_141_4_1 |
InParanoidi | H9GDU3 |
OMAi | YYYESDF |
TreeFami | TF315363 |
Family and domain databases
CDDi | cd00063, FN3, 2 hits |
Gene3Di | 1.10.150.50, 1 hit 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR027936, Eph_TM IPR003961, FN3_dom IPR036116, FN3_sf IPR013783, Ig-like_fold IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001660, SAM IPR013761, SAM/pointed_sf IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom |
Pfami | View protein in Pfam PF14575, EphA2_TM, 1 hit PF00041, fn3, 2 hits PF07714, PK_Tyr_Ser-Thr, 1 hit PF00536, SAM_1, 1 hit |
PRINTSi | PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00060, FN3, 2 hits SM00219, TyrKc, 1 hit |
SUPFAMi | SSF47769, SSF47769, 1 hit SSF49265, SSF49265, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50853, FN3, 2 hits PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit PS50105, SAM_DOMAIN, 1 hit |
i Sequence
Sequence statusi: Complete.
H9GDU3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
GCPSGTFKSS QGDEGCVHCP INSRTTSEGA TNCVCRNSYY RADSDPLDMP
60 70 80 90 100
CTTIPSAPQA VISSVNETSL MLEWSPPRDS GGREDLVYNL ICKSCGSGRG
110 120 130 140 150
ACTRCGDNVQ FAPRQLGLTE PRVYISDLLA HTQYTFEVQA VNGVTDQSPF
160 170 180 190 200
SPQFASVNIT TNQAAPSAVS IMHQVSRTVD SITLSWSQPD QPNGVILDYE
210 220 230 240 250
LQYYEKDLSE FNGTAVKSPT NTVTVQNLKA GTIYVFQVRA RTVAGYGRFS
260 270 280 290 300
GKMYFQTMTE AEYQTSIQEK LPLIIGSSAA GLVFLIALVV IVLVCNRRRG
310 320 330 340 350
FERADSEYTD KLQHYTSGHS TYSRAGLGSK RVGLVTPGMK IYIDPFTYED
360 370 380 390 400
PNEAVREFAK EIDISCVKIE QVIGAGEFGE VCSGHLKLPG KRESFVAIKT
410 420 430 440 450
LKSGYTEKQR RDFLSEASIM GQFDHPNVIH LEGVVTKSTP VMIVTEFMEN
460 470 480 490 500
GSLDSFLRQN DGQFTVIQLV GMLRGIAAGM KYLADMNYVH RDLAARNILV
510 520 530 540 550
NSNLVCKVSD FGLSRFLEDD TSDPTYTSAL GGKIPIRWTA PEAIQYRKFT
560 570 580 590 600
SASDVWSYGI VMWEVMSYGE RPYWDMTNQD VINAIEQDYR LPPPMDCPSA
610 620 630 640 650
LHQLMLDCWQ KDRNHRPKFG QIVNTLDKMI RNPNSLKAMA PLSSGINLPL
660 670 680 690
LDRTIPDYSS FNTVDEWLEA IKMGHYKENF ANGGFTNFDT VSQMTME
Genome annotation databases
Ensembli | ENSACAT00000008404; ENSACAP00000008227; ENSACAG00000008140 |
Similar proteinsi
Cross-referencesi
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000008227 |
Genome annotation databases
Ensembli | ENSACAT00000008404; ENSACAP00000008227; ENSACAG00000008140 |
Phylogenomic databases
eggNOGi | KOG0196, Eukaryota |
GeneTreei | ENSGT00940000155503 |
HOGENOMi | CLU_000288_141_4_1 |
InParanoidi | H9GDU3 |
OMAi | YYYESDF |
TreeFami | TF315363 |
Gene expression databases
Bgeei | ENSACAG00000008140, Expressed in embryo and 6 other tissues |
Family and domain databases
CDDi | cd00063, FN3, 2 hits |
Gene3Di | 1.10.150.50, 1 hit 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR027936, Eph_TM IPR003961, FN3_dom IPR036116, FN3_sf IPR013783, Ig-like_fold IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001660, SAM IPR013761, SAM/pointed_sf IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom |
Pfami | View protein in Pfam PF14575, EphA2_TM, 1 hit PF00041, fn3, 2 hits PF07714, PK_Tyr_Ser-Thr, 1 hit PF00536, SAM_1, 1 hit |
PRINTSi | PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00060, FN3, 2 hits SM00219, TyrKc, 1 hit |
SUPFAMi | SSF47769, SSF47769, 1 hit SSF49265, SSF49265, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50853, FN3, 2 hits PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit PS50105, SAM_DOMAIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | H9GDU3_ANOCA | |
Accessioni | H9GDU3Primary (citable) accession number: H9GDU3 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 16, 2012 |
Last sequence update: | May 16, 2012 | |
Last modified: | February 10, 2021 | |
This is version 64 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |