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Entry version 48 (07 Oct 2020)
Sequence version 2 (26 Jun 2013)
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Protein

AF-4_C domain-containing protein

Gene

AFF3

Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
AF-4_C domain-containing proteinInterPro annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AFF3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnolis carolinensis (Green anole) (American chameleon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri28377 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaIguaniaDactyloidaeAnolis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001646 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

NucleusARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

PhosphoproteinARBA annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSACAG00000008164, Expressed in testis and 11 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
28377.ENSACAP00000008035

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini934 – 1193AF-4_CInterPro annotationAdd BLAST260

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni112 – 138DisorderedSequence analysisAdd BLAST27
Regioni188 – 208DisorderedSequence analysisAdd BLAST21
Regioni266 – 466DisorderedSequence analysisAdd BLAST201
Regioni515 – 699DisorderedSequence analysisAdd BLAST185
Regioni779 – 804DisorderedSequence analysisAdd BLAST26
Regioni866 – 903DisorderedSequence analysisAdd BLAST38
Regioni1070 – 1115DisorderedSequence analysisAdd BLAST46

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili953 – 973Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi290 – 305PolarSequence analysisAdd BLAST16
Compositional biasi306 – 338PolyampholyteSequence analysisAdd BLAST33
Compositional biasi351 – 384PolyampholyteSequence analysisAdd BLAST34
Compositional biasi385 – 443PolarSequence analysisAdd BLAST59
Compositional biasi569 – 593PolarSequence analysisAdd BLAST25
Compositional biasi603 – 637PolyampholyteSequence analysisAdd BLAST35
Compositional biasi638 – 661PolarSequence analysisAdd BLAST24
Compositional biasi677 – 699PolarSequence analysisAdd BLAST23
Compositional biasi784 – 804PolyampholyteSequence analysisAdd BLAST21
Compositional biasi869 – 888PolarSequence analysisAdd BLAST20
Compositional biasi1070 – 1090PolarSequence analysisAdd BLAST21
Compositional biasi1097 – 1115PolarSequence analysisAdd BLAST19

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the AF4 family.ARBA annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QU9C, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182974

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_006484_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
H9GDL2

KEGG Orthology (KO)

More...
KOi
K15195

Database of Orthologous Groups

More...
OrthoDBi
558558at2759

TreeFam database of animal gene trees

More...
TreeFami
TF326216

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR043640, AF4/FMR2_C
IPR043639, AF4_int
IPR007797, TF_AF4/FMR2

The PANTHER Classification System

More...
PANTHERi
PTHR10528, PTHR10528, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF18876, AF-4_C, 1 hit
PF18875, AF4_int, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

H9GDL2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDSFDLALLQ EWDLDSLCVY DPDRNMLRRK EWERRNQDIQ HDDGLFNTSY
60 70 80 90 100
SLFSEPYKTN KGDELSSRIQ STLGNYDEMK ELLTDRSNQS HLVGVPKPCV
110 120 130 140 150
SQTSVTKAEE HFTADPKPHT QASICSPPTS LPVPPSGQLN KATTMGWQKS
160 170 180 190 200
GYTLESQPRG AKHRHGLSDS HCNDFKIANQ KNNLEKVKLY SSSPSSPSSS
210 220 230 240 250
TATQGLLPSA PVDSIRTQQQ PKLSCGADVG VQAQERTAMH SNGHCVQNFP
260 270 280 290 300
PSKPSIVQQK PTAYVRPMDG QDQAPDESPR LKVPAETSMV CSSYRGTPSA
310 320 330 340 350
KTDSTRTKSK PTKCDISKQD EDRAGDDSCV EEILRDSQHV STGHNNQRKS
360 370 380 390 400
GVEPKNPENR TSHTSMLEDD LKLSSDEEDS EQQAAQRSAL RVLSDSISVQ
410 420 430 440 450
QPNCRISGIS SKRSSSTSSS ESESSSESDS ESESSSAESD CNKPPHYSSP
460 470 480 490 500
EPEQPSSNKW QLDKWLNKVN PHKAPILNHN GLESFQYYCK AKDQGHNCES
510 520 530 540 550
LSSVCQTNLR DKEVKNPTKE ELCPRTANKA PGHKGAKQKP PPSATTVSVD
560 570 580 590 600
SGPLRRTACR KQLRKTERTS GGDNLNSSTG DNPDLNRVPL ENNSLCEQPK
610 620 630 640 650
PKPCTSKAEH RKEPQCVTPC EKRRTRGSGK IAPKSKEFIE TESSSSTSSD
660 670 680 690 700
TDSQSEQEEY PLQKPYTVAS VPVGSDQKLK DSGSSNTSKG NSCGAFGSVN
710 720 730 740 750
TRTSNDIAKE LDEQFYTLVP FGRNELLSPL KDTDEVKALW VKIDLTLLSR
760 770 780 790 800
VPQHSSEEPL LMNPGSKEAV GMQHNIAPDL SAEKVIPKSR RKRKYENEEE
810 820 830 840 850
NRDSKKIHIE QLCSSHLLAS SQVISTSNHC NMIKNSLGTP INKNEKMLQS
860 870 880 890 900
PVSPLPDASK HKFFSEDLTS SSKRNGSNLL SSISSSKRRK NESQTHHPGN
910 920 930 940 950
FNKMVYVSSD STPLCNKTQC QKEPWSPVSS MHQDCRRSKL ILNDGPHNID
960 970 980 990 1000
YFMQEAKRKK HKADAMVEKF SKALNYVEAA LSFIECGNAM EQGPTESKSP
1010 1020 1030 1040 1050
YTMYSETVEL IRYAVRLKTH SVPSATPEEK QLATLCYRCL ALLYWRMFRL
1060 1070 1080 1090 1100
KRDHAVKYSK ALIEYFKNSS KGAQAPSPWG TSGKHTGTPS PISPSPSPVS
1110 1120 1130 1140 1150
SVGSQGSTGA PSPSSIVSIP QRIHQMAANH VSITNSILHS YDYWEMADNL
1160 1170 1180 1190
AKENQDFFND LDALMGPVTL HSSMDHLVQY TQQGLLWIRS SAQFS
Length:1,195
Mass (Da):132,350
Last modified:June 26, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i637123B7375ADD95
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAWZ02028298 Genomic DNA No translation available.
AAWZ02028299 Genomic DNA No translation available.
AAWZ02028300 Genomic DNA No translation available.
AAWZ02028301 Genomic DNA No translation available.
AAWZ02028302 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_008118477.1, XM_008120270.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSACAT00000008206; ENSACAP00000008035; ENSACAG00000008164

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100554189

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
acs:100554189

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAWZ02028298 Genomic DNA No translation available.
AAWZ02028299 Genomic DNA No translation available.
AAWZ02028300 Genomic DNA No translation available.
AAWZ02028301 Genomic DNA No translation available.
AAWZ02028302 Genomic DNA No translation available.
RefSeqiXP_008118477.1, XM_008120270.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi28377.ENSACAP00000008035

Genome annotation databases

EnsembliENSACAT00000008206; ENSACAP00000008035; ENSACAG00000008164
GeneIDi100554189
KEGGiacs:100554189

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3899

Phylogenomic databases

eggNOGiENOG502QU9C, Eukaryota
GeneTreeiENSGT00950000182974
HOGENOMiCLU_006484_1_1_1
InParanoidiH9GDL2
KOiK15195
OrthoDBi558558at2759
TreeFamiTF326216

Gene expression databases

BgeeiENSACAG00000008164, Expressed in testis and 11 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR043640, AF4/FMR2_C
IPR043639, AF4_int
IPR007797, TF_AF4/FMR2
PANTHERiPTHR10528, PTHR10528, 1 hit
PfamiView protein in Pfam
PF18876, AF-4_C, 1 hit
PF18875, AF4_int, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH9GDL2_ANOCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H9GDL2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 16, 2012
Last sequence update: June 26, 2013
Last modified: October 7, 2020
This is version 48 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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Main funding by: National Institutes of Health

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