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UniProtKB - H9GDK3 (H9GDK3_ANOCA)

Entry version 59 (10 Feb 2021)
Sequence version 1 (16 May 2012)
Previous versions | rss
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Protein
Submitted name:

Uncharacterized protein

Gene

TLN2

Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TLN2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnolis carolinensis (Green anole) (American chameleon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri28377 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Iguania › Dactyloidae › Anolis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001646 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membraneARBA annotation, CytoplasmARBA annotation, Membrane

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSACAG00000007879, Expressed in skeletal muscle tissue and 13 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		28377.ENSACAP00000008017

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 123FERMInterPro annotationAdd BLAST123
Domaini2010 – 2249I/LWEQInterPro annotationAdd BLAST240

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2234 – 2256DisorderedSequence analysisAdd BLAST23

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili768 – 788Sequence analysisAdd BLAST21
Coiled coili953 – 973Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4261, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154699

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000364_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		H9GDK3

Identification of Orthologs from Complete Genome Data

More...OMAi		QTSMVKH

TreeFam database of animal gene trees

More...TreeFami		TF314677

Family and domain databases

Conserved Domains Database

More...CDDi		cd12150, talin-RS, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR036723, Alpha-catenin/vinculin-like_sf
IPR019747, FERM_CS
IPR000299, FERM_domain
IPR035964, I/LWEQ_dom_sf
IPR002558, ILWEQ_dom
IPR011993, PH-like_dom_sf
IPR037438, Talin1/2-RS
IPR015224, Talin_cent
IPR036476, Talin_cent_sf
IPR015009, Vinculin-bd_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01608, I_LWEQ, 2 hits
PF09141, Talin_middle, 1 hit
PF08913, VBS, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00307, ILWEQ, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF109880, SSF109880, 1 hit
SSF109885, SSF109885, 5 hits
SSF47220, SSF47220, 5 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00661, FERM_2, 1 hit
PS50057, FERM_3, 1 hit
PS50945, I_LWEQ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

H9GDK3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
QEHKNCGEMA EIEAKVKYVK LARSLRTYGV SFFLVKEKMK GKNKLVPRLL 
        60         70         80         90        100
GVTKESVMRV DERTKEVLQE WPLTTVKRWA ASPKSFTLDF GEYQESYYSV 
       110        120        130        140        150
QTTEGEQISQ LIAGYIDIIL KKKQSKDRFG LEGDEESTML EESVSPKKST 
       160        170        180        190        200
ILQQQFNRTG KVEHGSVALP AVMRSGSTGP EPFNMGSMPS PQQQVTVGQM 
       210        220        230        240        250
HRGHMPPLTS AQQALMGTLN TSRQAVQQAQ ADLTEVDSLP PLGNDMASRV 
       260        270        280        290        300
WVQNKVDESK HEIHSQVDAI TAGTASVVNL TAGDPVDTDY TAVGCAITTI 
       310        320        330        340        350
SSNLTEMSKG VKLLAALMDD EVGSREDLLK AARTLAGAVS DLLKAVEPAS 
       360        370        380        390        400
GEPRQTVLTA AGSIGQASGE LLRQIGENET DERFQDVLMS LAKAVANAAA 
       410        420        430        440        450
MLVLKAKNVA QVAEDAVLQN RVIAAATQCA LSTSQLVACA KVVSPTISSP 
       460        470        480        490        500
VCQEQLMEAG RLVDRSVEGC VRACQAATDD MELLKQVSAA AGVVSQALSD 
       510        520        530        540        550
LLQHVRQFAS RGEPIGRYDQ ATDTIMCVTE SIFSSMGDAG EMVRQARLAQ 
       560        570        580        590        600
ATSDLVNAMR SDAEAEIDME NSKKLLAAAK LLADSTARMV EAAKGAAANP 
       610        620        630        640        650
ENEDQQQRLR EAAEGLRVAT NAAAQNAIKK KIVNRLEVAA KQAAAAATQT 
       660        670        680        690        700
IAASQNAAIS NKNTSAHQQL VQSCKSVADH IPQLVQGVRG SQAQAEDLSA 
       710        720        730        740        750
QLALINSSQN FLQPGSRMVS SAKAAVPTVG DQAAAMQLSQ CAKNLATSLA 
       760        770        780        790        800
ELRTASQKAH EACGPMEIDS ALSTVQTLKN ELQDAKMAAV EGQLKPLPGE 
       810        820        830        840        850
TLEKCAQDLG STSKAVGSSM AQLLTCAAQG NEHYTGVAAR ETAQALKSLA 
       860        870        880        890        900
QAARGVSAST GDPPAAHAML DSARDVMEGS AVLIQEAKQA LGAPGDADRQ 
       910        920        930        940        950
QRLAQVAKAV SHSLNNCVNC LPGQKDVDVA LKSIGESSKK LLVESLPPSS 
       960        970        980        990       1000
KSFQEAQSEL NQAAADLNQS AGEVVHATRG QSGELAAASG KFSEDFDEFL 
      1010       1020       1030       1040       1050
GAGIEMAGQA QTKEDQIQVI GNLKNISMAS SKLLLAAKSL SVDPGAPNAK 
      1060       1070       1080       1090       1100
NLLAAAARAV TESINQLITL CTQQAPGQKE CDNALRELET VKEMLENPNE 
      1110       1120       1130       1140       1150
PVSDLSYFDC IEGVMENSKV LGEAMAGISQ NAKTGDLPAF GECVGVASKA 
      1160       1170       1180       1190       1200
LCGLTEAAAQ AAFLVGVSDP NSQAGQQGLV DPIQFARANQ AIQMACQNLV 
      1210       1220       1230       1240       1250
DPASSPSQVL SAATIVAKHT SALCNACRIA SSKTANPVAK RHFVQSAKEV 
      1260       1270       1280       1290       1300
ANSTANLVKT IKALDGDFSE DNRNKCRVAT APLIEAVENL TAFASNPEFV 
      1310       1320       1330       1340       1350
SIPAQISAEG SHAQEPLLTS ARTMLESSSW LIRTARSLAI NPKDPSAWSV 
      1360       1370       1380       1390       1400
LAAHSHTVSE AIKSLITSIR DKAPGQRECD HSIDGINKCI RDIEQASLAA 
      1410       1420       1430       1440       1450
VSQNLAARDD ISVEALQEQL TSVVQEIGHL IDPIATAARG EAAQLGHKVT 
      1460       1470       1480       1490       1500
QLASYFEPLV LAAVGLVSKL MSHQQQMTLL DQTKTLAESA LQTLYAAKEG 
      1510       1520       1530       1540       1550
GGNPKKASHT HDAITEAAQL MKEAVDDLMV TLNEAASEVG MVANMVDSIA 
      1560       1570       1580       1590       1600
EAMSKLDEGT PPETKASFVD YQTTVVKYSK AIAVTAQEMM TKAVTNPEEL 
      1610       1620       1630       1640       1650
GGLASQMTTD YGHLAFQGRM AAATAEPEEI GLQIRARVQE LGHGCIFLVQ 
      1660       1670       1680       1690       1700
KGGALQVCPT DSYTKRELIE CARAVSEKVS LVLSALQAGN KGTQACITAA 
      1710       1720       1730       1740       1750
SAVSGIIADL DTTIMFATAG TLHAENNESF ADHRENILKT AKALVEDTKL 
      1760       1770       1780       1790       1800
LVSGAASSQE QLAQAAHSSA STITQLAEVV KLGAASLGSD DPETQVVLIN 
      1810       1820       1830       1840       1850
AIKDVAKALS DLIGATKGAA SKPADDPSMY QLKGAAKVMV TNVTSLLKTV 
      1860       1870       1880       1890       1900
KAVEDEATRG TRALEATIEY IKQELTVFQS KEVPEGSSSP ESIRMTKGIT 
      1910       1920       1930       1940       1950
MATAKAVAAG NSCRQKDVIA TANLSRKAVA DMLTACKQAS FHLEVSEEVR 
      1960       1970       1980       1990       2000
ARALRYGTEC TLGYLALLEH VLAILQKPTP ELKQPLAALS KRVASAVTEL 
      2010       2020       2030       2040       2050
IQAAEAMKGT EWVDPEDPTV IAETELLGAA ASIEAAAKKL EQLKPRAKPK 
      2060       2070       2080       2090       2100
QADETLDFEE QILEAAKSIA AATSALVKSA SAAQRELVAQ GKVGAIPANA 
      2110       2120       2130       2140       2150
ADDGQWSQGL ISAARMVAAA TSSLCEAANA SVQGHASEEK LISSAKQVAA 
      2160       2170       2180       2190       2200
STAQLLVACK VKADQDSEAM RRLQAAGNAV KRASDNLVRA AQKAAFGKAD 
      2210       2220       2230       2240       2250
DDDVVVKTKF VGGIAQIIAA QEEMLKKERE LEEARKKARS RQQQYKFLPT 

ELREDE
Length:2,256
Mass (Da):238,127
Last modified:May 16, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB0279573984863BB
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AAWZ02035976 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSACAT00000008188; ENSACAP00000008017; ENSACAG00000007879

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAWZ02035976 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi28377.ENSACAP00000008017

Genome annotation databases

EnsembliENSACAT00000008188; ENSACAP00000008017; ENSACAG00000007879

Phylogenomic databases

eggNOGiKOG4261, Eukaryota
GeneTreeiENSGT00940000154699
HOGENOMiCLU_000364_1_1_1
InParanoidiH9GDK3
OMAiQTSMVKH
TreeFamiTF314677

Gene expression databases

BgeeiENSACAG00000007879, Expressed in skeletal muscle tissue and 13 other tissues

Family and domain databases

CDDicd12150, talin-RS, 1 hit
Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR036723, Alpha-catenin/vinculin-like_sf
IPR019747, FERM_CS
IPR000299, FERM_domain
IPR035964, I/LWEQ_dom_sf
IPR002558, ILWEQ_dom
IPR011993, PH-like_dom_sf
IPR037438, Talin1/2-RS
IPR015224, Talin_cent
IPR036476, Talin_cent_sf
IPR015009, Vinculin-bd_dom
PfamiView protein in Pfam
PF01608, I_LWEQ, 2 hits
PF09141, Talin_middle, 1 hit
PF08913, VBS, 1 hit
SMARTiView protein in SMART
SM00307, ILWEQ, 1 hit
SUPFAMiSSF109880, SSF109880, 1 hit
SSF109885, SSF109885, 5 hits
SSF47220, SSF47220, 5 hits
PROSITEiView protein in PROSITE
PS00661, FERM_2, 1 hit
PS50057, FERM_3, 1 hit
PS50945, I_LWEQ, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH9GDK3_ANOCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H9GDK3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 16, 2012
Last sequence update: May 16, 2012
Last modified: February 10, 2021
This is version 59 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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Main funding by: National Institutes of Health

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