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Entry version 59 (10 Feb 2021)
Sequence version 1 (16 May 2012)
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Protein
Submitted name:

Uncharacterized protein

Gene

TLN2

Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TLN2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnolis carolinensis (Green anole) (American chameleon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri28377 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaIguaniaDactyloidaeAnolis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001646 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membraneARBA annotation, CytoplasmARBA annotation, Membrane

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSACAG00000007879, Expressed in skeletal muscle tissue and 13 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
28377.ENSACAP00000008017

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 123FERMInterPro annotationAdd BLAST123
Domaini2010 – 2249I/LWEQInterPro annotationAdd BLAST240

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2234 – 2256DisorderedSequence analysisAdd BLAST23

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili768 – 788Sequence analysisAdd BLAST21
Coiled coili953 – 973Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4261, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154699

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000364_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
H9GDK3

Identification of Orthologs from Complete Genome Data

More...
OMAi
QTSMVKH

TreeFam database of animal gene trees

More...
TreeFami
TF314677

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12150, talin-RS, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036723, Alpha-catenin/vinculin-like_sf
IPR019747, FERM_CS
IPR000299, FERM_domain
IPR035964, I/LWEQ_dom_sf
IPR002558, ILWEQ_dom
IPR011993, PH-like_dom_sf
IPR037438, Talin1/2-RS
IPR015224, Talin_cent
IPR036476, Talin_cent_sf
IPR015009, Vinculin-bd_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01608, I_LWEQ, 2 hits
PF09141, Talin_middle, 1 hit
PF08913, VBS, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00307, ILWEQ, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF109880, SSF109880, 1 hit
SSF109885, SSF109885, 5 hits
SSF47220, SSF47220, 5 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00661, FERM_2, 1 hit
PS50057, FERM_3, 1 hit
PS50945, I_LWEQ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

H9GDK3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
QEHKNCGEMA EIEAKVKYVK LARSLRTYGV SFFLVKEKMK GKNKLVPRLL
60 70 80 90 100
GVTKESVMRV DERTKEVLQE WPLTTVKRWA ASPKSFTLDF GEYQESYYSV
110 120 130 140 150
QTTEGEQISQ LIAGYIDIIL KKKQSKDRFG LEGDEESTML EESVSPKKST
160 170 180 190 200
ILQQQFNRTG KVEHGSVALP AVMRSGSTGP EPFNMGSMPS PQQQVTVGQM
210 220 230 240 250
HRGHMPPLTS AQQALMGTLN TSRQAVQQAQ ADLTEVDSLP PLGNDMASRV
260 270 280 290 300
WVQNKVDESK HEIHSQVDAI TAGTASVVNL TAGDPVDTDY TAVGCAITTI
310 320 330 340 350
SSNLTEMSKG VKLLAALMDD EVGSREDLLK AARTLAGAVS DLLKAVEPAS
360 370 380 390 400
GEPRQTVLTA AGSIGQASGE LLRQIGENET DERFQDVLMS LAKAVANAAA
410 420 430 440 450
MLVLKAKNVA QVAEDAVLQN RVIAAATQCA LSTSQLVACA KVVSPTISSP
460 470 480 490 500
VCQEQLMEAG RLVDRSVEGC VRACQAATDD MELLKQVSAA AGVVSQALSD
510 520 530 540 550
LLQHVRQFAS RGEPIGRYDQ ATDTIMCVTE SIFSSMGDAG EMVRQARLAQ
560 570 580 590 600
ATSDLVNAMR SDAEAEIDME NSKKLLAAAK LLADSTARMV EAAKGAAANP
610 620 630 640 650
ENEDQQQRLR EAAEGLRVAT NAAAQNAIKK KIVNRLEVAA KQAAAAATQT
660 670 680 690 700
IAASQNAAIS NKNTSAHQQL VQSCKSVADH IPQLVQGVRG SQAQAEDLSA
710 720 730 740 750
QLALINSSQN FLQPGSRMVS SAKAAVPTVG DQAAAMQLSQ CAKNLATSLA
760 770 780 790 800
ELRTASQKAH EACGPMEIDS ALSTVQTLKN ELQDAKMAAV EGQLKPLPGE
810 820 830 840 850
TLEKCAQDLG STSKAVGSSM AQLLTCAAQG NEHYTGVAAR ETAQALKSLA
860 870 880 890 900
QAARGVSAST GDPPAAHAML DSARDVMEGS AVLIQEAKQA LGAPGDADRQ
910 920 930 940 950
QRLAQVAKAV SHSLNNCVNC LPGQKDVDVA LKSIGESSKK LLVESLPPSS
960 970 980 990 1000
KSFQEAQSEL NQAAADLNQS AGEVVHATRG QSGELAAASG KFSEDFDEFL
1010 1020 1030 1040 1050
GAGIEMAGQA QTKEDQIQVI GNLKNISMAS SKLLLAAKSL SVDPGAPNAK
1060 1070 1080 1090 1100
NLLAAAARAV TESINQLITL CTQQAPGQKE CDNALRELET VKEMLENPNE
1110 1120 1130 1140 1150
PVSDLSYFDC IEGVMENSKV LGEAMAGISQ NAKTGDLPAF GECVGVASKA
1160 1170 1180 1190 1200
LCGLTEAAAQ AAFLVGVSDP NSQAGQQGLV DPIQFARANQ AIQMACQNLV
1210 1220 1230 1240 1250
DPASSPSQVL SAATIVAKHT SALCNACRIA SSKTANPVAK RHFVQSAKEV
1260 1270 1280 1290 1300
ANSTANLVKT IKALDGDFSE DNRNKCRVAT APLIEAVENL TAFASNPEFV
1310 1320 1330 1340 1350
SIPAQISAEG SHAQEPLLTS ARTMLESSSW LIRTARSLAI NPKDPSAWSV
1360 1370 1380 1390 1400
LAAHSHTVSE AIKSLITSIR DKAPGQRECD HSIDGINKCI RDIEQASLAA
1410 1420 1430 1440 1450
VSQNLAARDD ISVEALQEQL TSVVQEIGHL IDPIATAARG EAAQLGHKVT
1460 1470 1480 1490 1500
QLASYFEPLV LAAVGLVSKL MSHQQQMTLL DQTKTLAESA LQTLYAAKEG
1510 1520 1530 1540 1550
GGNPKKASHT HDAITEAAQL MKEAVDDLMV TLNEAASEVG MVANMVDSIA
1560 1570 1580 1590 1600
EAMSKLDEGT PPETKASFVD YQTTVVKYSK AIAVTAQEMM TKAVTNPEEL
1610 1620 1630 1640 1650
GGLASQMTTD YGHLAFQGRM AAATAEPEEI GLQIRARVQE LGHGCIFLVQ
1660 1670 1680 1690 1700
KGGALQVCPT DSYTKRELIE CARAVSEKVS LVLSALQAGN KGTQACITAA
1710 1720 1730 1740 1750
SAVSGIIADL DTTIMFATAG TLHAENNESF ADHRENILKT AKALVEDTKL
1760 1770 1780 1790 1800
LVSGAASSQE QLAQAAHSSA STITQLAEVV KLGAASLGSD DPETQVVLIN
1810 1820 1830 1840 1850
AIKDVAKALS DLIGATKGAA SKPADDPSMY QLKGAAKVMV TNVTSLLKTV
1860 1870 1880 1890 1900
KAVEDEATRG TRALEATIEY IKQELTVFQS KEVPEGSSSP ESIRMTKGIT
1910 1920 1930 1940 1950
MATAKAVAAG NSCRQKDVIA TANLSRKAVA DMLTACKQAS FHLEVSEEVR
1960 1970 1980 1990 2000
ARALRYGTEC TLGYLALLEH VLAILQKPTP ELKQPLAALS KRVASAVTEL
2010 2020 2030 2040 2050
IQAAEAMKGT EWVDPEDPTV IAETELLGAA ASIEAAAKKL EQLKPRAKPK
2060 2070 2080 2090 2100
QADETLDFEE QILEAAKSIA AATSALVKSA SAAQRELVAQ GKVGAIPANA
2110 2120 2130 2140 2150
ADDGQWSQGL ISAARMVAAA TSSLCEAANA SVQGHASEEK LISSAKQVAA
2160 2170 2180 2190 2200
STAQLLVACK VKADQDSEAM RRLQAAGNAV KRASDNLVRA AQKAAFGKAD
2210 2220 2230 2240 2250
DDDVVVKTKF VGGIAQIIAA QEEMLKKERE LEEARKKARS RQQQYKFLPT

ELREDE
Length:2,256
Mass (Da):238,127
Last modified:May 16, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB0279573984863BB
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAWZ02035976 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSACAT00000008188; ENSACAP00000008017; ENSACAG00000007879

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAWZ02035976 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi28377.ENSACAP00000008017

Genome annotation databases

EnsembliENSACAT00000008188; ENSACAP00000008017; ENSACAG00000007879

Phylogenomic databases

eggNOGiKOG4261, Eukaryota
GeneTreeiENSGT00940000154699
HOGENOMiCLU_000364_1_1_1
InParanoidiH9GDK3
OMAiQTSMVKH
TreeFamiTF314677

Gene expression databases

BgeeiENSACAG00000007879, Expressed in skeletal muscle tissue and 13 other tissues

Family and domain databases

CDDicd12150, talin-RS, 1 hit
Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR036723, Alpha-catenin/vinculin-like_sf
IPR019747, FERM_CS
IPR000299, FERM_domain
IPR035964, I/LWEQ_dom_sf
IPR002558, ILWEQ_dom
IPR011993, PH-like_dom_sf
IPR037438, Talin1/2-RS
IPR015224, Talin_cent
IPR036476, Talin_cent_sf
IPR015009, Vinculin-bd_dom
PfamiView protein in Pfam
PF01608, I_LWEQ, 2 hits
PF09141, Talin_middle, 1 hit
PF08913, VBS, 1 hit
SMARTiView protein in SMART
SM00307, ILWEQ, 1 hit
SUPFAMiSSF109880, SSF109880, 1 hit
SSF109885, SSF109885, 5 hits
SSF47220, SSF47220, 5 hits
PROSITEiView protein in PROSITE
PS00661, FERM_2, 1 hit
PS50057, FERM_3, 1 hit
PS50945, I_LWEQ, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH9GDK3_ANOCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H9GDK3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 16, 2012
Last sequence update: May 16, 2012
Last modified: February 10, 2021
This is version 59 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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