UniProtKB - H9GDA6 (H9GDA6_ANOCA)
Protein
Glycerol-3-phosphate dehydrogenase
Gene
GPD2
Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Functioni
Calcium-responsive mitochondrial glycerol-3-phosphate dehydrogenase which seems to be a key component of the pancreatic beta-cell glucose-sensing device.ARBA annotation
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
Catalytic activityi
- EC:1.1.5.3UniRule annotation
Cofactori
FADUniRule annotationARBA annotation
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Calcium bindingi | 672 – 683 | PROSITE-ProRule annotationAdd BLAST | 12 |
GO - Molecular functioni
- calcium ion binding Source: InterPro
- sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity Source: UniProtKB-EC
GO - Biological processi
- camera-type eye development Source: Ensembl
- gluconeogenesis Source: Ensembl
- glycerol-3-phosphate metabolic process Source: UniProtKB-UniRule
- multicellular organism growth Source: Ensembl
Keywordsi
Molecular function | OxidoreductaseUniRule annotationARBA annotation |
Ligand | CalciumPROSITE-ProRule annotation, FADARBA annotation, Flavoprotein |
Names & Taxonomyi
Protein namesi | Recommended name: Glycerol-3-phosphate dehydrogenaseUniRule annotation (EC:1.1.5.3UniRule annotation) |
Gene namesi | Name:GPD2Imported |
Organismi | Anolis carolinensis (Green anole) (American chameleon)Imported |
Taxonomic identifieri | 28377 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Iguania › Dactyloidae › Anolis |
Proteomesi |
|
Subcellular locationi
Extracellular region or secreted
- extracellular region Source: UniProtKB-KW
Mitochondrion
- mitochondrion Source: GO_Central
Other locations
- glycerol-3-phosphate dehydrogenase complex Source: UniProtKB-UniRule
Keywords - Cellular componenti
MitochondrionARBA annotation, SecretedARBA annotationExpressioni
Gene expression databases
Bgeei | ENSACAG00000007854, Expressed in skeletal muscle tissue and 14 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 623 – 658 | EF-handInterPro annotationAdd BLAST | 36 | |
Domaini | 659 – 694 | EF-handInterPro annotationAdd BLAST | 36 |
Sequence similaritiesi
Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.UniRule annotationARBA annotation
Keywords - Domaini
Transit peptideARBA annotationPhylogenomic databases
eggNOGi | KOG0042, Eukaryota |
GeneTreei | ENSGT00390000001718 |
HOGENOMi | CLU_015740_3_1_1 |
InParanoidi | H9GDA6 |
TreeFami | TF300359 |
Family and domain databases
CDDi | cd00051, EFh, 1 hit |
Gene3Di | 1.10.8.870, 1 hit 3.50.50.60, 1 hit |
InterProi | View protein in InterPro IPR031656, DAO_C IPR038299, DAO_C_sf IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR006076, FAD-dep_OxRdtase IPR036188, FAD/NAD-bd_sf IPR000447, G3P_DH_FAD-dep |
PANTHERi | PTHR11985, PTHR11985, 1 hit |
Pfami | View protein in Pfam PF01266, DAO, 1 hit PF16901, DAO_C, 1 hit PF13499, EF-hand_7, 1 hit |
PRINTSi | PR01001, FADG3PDH |
SMARTi | View protein in SMART SM00054, EFh, 2 hits |
SUPFAMi | SSF47473, SSF47473, 1 hit SSF51905, SSF51905, 1 hit |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 1 hit PS50222, EF_HAND_2, 2 hits PS00977, FAD_G3PDH_1, 1 hit |
i Sequence
Sequence statusi: Complete.
H9GDA6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAFRKAMKGA VLVGGGAVAT VFALSQLSQY RKKHSHLVSV EASECKPLQM
60 70 80 90 100
HRSLPTREHQ LQALQQTSEF DVLIIGGGAT GSGCALDAVS RGLKTALVER
110 120 130 140 150
DDFSSGTSSR STKLIHGGVR YLQKAIMKLD FDQYRMVKEA LHERANLLEI
160 170 180 190 200
APHLSSPLPI MLPVYKWWQL PYYWVGIKLY DLVAGSQCLK SSYVLSKSKA
210 220 230 240 250
LELFPMLQKD RLVGAIVYYD GQHNDARMNL AIALTAARYG AAIANYTEVM
260 270 280 290 300
HLLKKTDPNS GKSHVCGARC RDVLTGQEFD VNAKCVINAT GPFTDSVRKM
310 320 330 340 350
DDQEVLNICQ PSAGVHIVMP GYYSPDNMGL LDPSTSDGRV IFFLPWQKMT
360 370 380 390 400
IAGTTDTATE VTHHPIPTEE DINFILTEVR NYLSCDVEVR RGDVLAAWSG
410 420 430 440 450
IRPLVTDPNS KDTQSISRNH VVHVSDSGLV TIAGGKWTTY RSMAEDTIDA
460 470 480 490 500
AVKAHGLKAG PCKTSGLLLQ GAEGWSPTLY IRLVQDYGLE SEVAQHLSNT
510 520 530 540 550
FGDKAFEVAK LAQVTGKRWP IVGKRLVSEF PYIESEIEYG IQEYACTAVD
560 570 580 590 600
MIARRTRLAF LNVQAADEAL PRIIEIMGKR LKWSEQKKKE QLEEAKKFLY
610 620 630 640 650
YEMGYKARSE QLTDRSEITL SPRDIERYKK RFHMFDKEGK GFITILDVQR
660 670 680 690 700
VLESINFQIN ESALHEILTE VDLNKNGQVE LNEFLQLMTA IQKGSISGSR
710 720 730 740 750
LAVLMKAAEE NICRREVISV DRSGGGLSSF PSLKSQAAIS AQPVLSPFLL
ISRVL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAWZ02022104 Genomic DNA No translation available. AAWZ02022105 Genomic DNA No translation available. AAWZ02022106 Genomic DNA No translation available. AAWZ02022107 Genomic DNA No translation available. AAWZ02022108 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENSACAT00000007979; ENSACAP00000007813; ENSACAG00000007854 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAWZ02022104 Genomic DNA No translation available. AAWZ02022105 Genomic DNA No translation available. AAWZ02022106 Genomic DNA No translation available. AAWZ02022107 Genomic DNA No translation available. AAWZ02022108 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000007813 |
Genome annotation databases
Ensembli | ENSACAT00000007979; ENSACAP00000007813; ENSACAG00000007854 |
Phylogenomic databases
eggNOGi | KOG0042, Eukaryota |
GeneTreei | ENSGT00390000001718 |
HOGENOMi | CLU_015740_3_1_1 |
InParanoidi | H9GDA6 |
TreeFami | TF300359 |
Gene expression databases
Bgeei | ENSACAG00000007854, Expressed in skeletal muscle tissue and 14 other tissues |
Family and domain databases
CDDi | cd00051, EFh, 1 hit |
Gene3Di | 1.10.8.870, 1 hit 3.50.50.60, 1 hit |
InterProi | View protein in InterPro IPR031656, DAO_C IPR038299, DAO_C_sf IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR006076, FAD-dep_OxRdtase IPR036188, FAD/NAD-bd_sf IPR000447, G3P_DH_FAD-dep |
PANTHERi | PTHR11985, PTHR11985, 1 hit |
Pfami | View protein in Pfam PF01266, DAO, 1 hit PF16901, DAO_C, 1 hit PF13499, EF-hand_7, 1 hit |
PRINTSi | PR01001, FADG3PDH |
SMARTi | View protein in SMART SM00054, EFh, 2 hits |
SUPFAMi | SSF47473, SSF47473, 1 hit SSF51905, SSF51905, 1 hit |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 1 hit PS50222, EF_HAND_2, 2 hits PS00977, FAD_G3PDH_1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | H9GDA6_ANOCA | |
Accessioni | H9GDA6Primary (citable) accession number: H9GDA6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 16, 2012 |
Last sequence update: | June 26, 2013 | |
Last modified: | December 2, 2020 | |
This is version 45 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |