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Entry version 63 (07 Oct 2020)
Sequence version 2 (26 Jun 2013)
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Protein

RING-type E3 ubiquitin transferase

Gene

TRIM36

Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.ARBA annotation EC:2.3.2.27

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RING-type E3 ubiquitin transferaseARBA annotation (EC:2.3.2.27ARBA annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TRIM36Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnolis carolinensis (Green anole) (American chameleon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri28377 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaIguaniaDactyloidaeAnolis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001646 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, CytoskeletonARBA annotation, MicrotubuleARBA annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSACAG00000007939, Expressed in brain and 12 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
28377.ENSACAP00000007804

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini21 – 73RING-typeInterPro annotationAdd BLAST53
Domaini196 – 238B box-typeInterPro annotationAdd BLAST43
Domaini345 – 402COSInterPro annotationAdd BLAST58
Domaini405 – 501Fibronectin type-IIIInterPro annotationAdd BLAST97
Domaini486 – 716B30.2/SPRYInterPro annotationAdd BLAST231

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni61 – 82DisorderedSequence analysisAdd BLAST22

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi61 – 75PolarSequence analysisAdd BLAST15

Keywords - Domaini

Coiled coilARBA annotation, Zinc-fingerPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2177, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158373

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_013137_19_3_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
H9GDA3

TreeFam database of animal gene trees

More...
TreeFami
TF315216

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00021, BBOX, 1 hit
cd00063, FN3, 1 hit
cd12894, SPRY_PRY_TRIM36, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.920, 1 hit
2.60.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001870, B30.2/SPRY
IPR043136, B30.2/SPRY_sf
IPR003649, Bbox_C
IPR013320, ConA-like_dom_sf
IPR017903, COS_domain
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR013783, Ig-like_fold
IPR040859, Midline-1_COS
IPR035727, SPRY/PRY_TRIM36
IPR027726, Trim36
IPR027370, Znf-RING_LisH
IPR000315, Znf_B-box
IPR001841, Znf_RING
IPR017907, Znf_RING_CS

The PANTHER Classification System

More...
PANTHERi
PTHR24099:SF18, PTHR24099:SF18, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF18568, COS, 1 hit
PF00041, fn3, 1 hit
PF00643, zf-B_box, 1 hit
PF13445, zf-RING_UBOX, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00502, BBC, 1 hit
SM00336, BBOX, 1 hit
SM00184, RING, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49265, SSF49265, 1 hit
SSF49899, SSF49899, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50188, B302_SPRY, 1 hit
PS51262, COS, 1 hit
PS50853, FN3, 1 hit
PS50119, ZF_BBOX, 1 hit
PS00518, ZF_RING_1, 1 hit
PS50089, ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

H9GDA3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEGDRLEPAV TIKNIERELI CPACKELFTH PVILPCQHSI CHKCVKEILY
60 70 80 90 100
FSLEDPFNDS ASETSNQSSP RNRMHSPSLD RIDRVNRSGW KRNSLTPKTT
110 120 130 140 150
VFPCPGCRHD IDLGERGISG LFRNFTLETI VERYRQAARA ATAIMCDLCK
160 170 180 190 200
PPPQESTKSC MDCSASYCNE CFKIHHPWGT LKAQHEYVGP TTNFRPKILM
210 220 230 240 250
CPEHEMERVN MYCELCKRPV CHLCKLGGTH ANHRVTSMSS AYKILKEKLS
260 270 280 290 300
KDIDYLISKE SQVKSQITEL GLLMKEAECN GERAKEEASN NFDKLFDVLE
310 320 330 340 350
ERRATALRAI EASKNMRLEK LQSQIEEYQG LLENNGLVGY AQEVLKETDQ
360 370 380 390 400
SCFVQTAKQL HERIQKATES LRSFRPAAQA SFEDFVVDIA KQQEALGDLS
410 420 430 440 450
FHSSGVDIPE INEEQTKMYN KALISWDQPQ KISSADTYIL EYRKLNREET
460 470 480 490 500
PPVWQEREVF SKSEIVSDLD TNSSYAFRVR GYKGSICSPW SREVILHTPP
510 520 530 540 550
APVFSFLFDD KCGYNAEHLI LNMRRNAVEN KAGFPLLLGA DRIQAGCYTT
560 570 580 590 600
LDYIIGDTGI VKGKHFWAFH VEPYSYLVKA GVASDVKIQE WFHNSRDLTS
610 620 630 640 650
PRYEQDSGHD SGSEDIFVES LQPFTLVTLG MKKFFIPKAS PAPVTPKDAV
660 670 680 690 700
NRILPMPSSI GICLDCDKGK VGFYDADRMK CLYERQVDCS GTMYPAFALM
710 720
GSAGIHLEET IAAKYLQYQD EDM
Length:723
Mass (Da):82,031
Last modified:June 26, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1560F2A8E4F8B09A
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAWZ02001651 Genomic DNA No translation available.
AAWZ02001652 Genomic DNA No translation available.
AAWZ02001653 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSACAT00000007970; ENSACAP00000007804; ENSACAG00000007939

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAWZ02001651 Genomic DNA No translation available.
AAWZ02001652 Genomic DNA No translation available.
AAWZ02001653 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi28377.ENSACAP00000007804

Genome annotation databases

EnsembliENSACAT00000007970; ENSACAP00000007804; ENSACAG00000007939

Phylogenomic databases

eggNOGiKOG2177, Eukaryota
GeneTreeiENSGT00940000158373
HOGENOMiCLU_013137_19_3_1
InParanoidiH9GDA3
TreeFamiTF315216

Gene expression databases

BgeeiENSACAG00000007939, Expressed in brain and 12 other tissues

Family and domain databases

CDDicd00021, BBOX, 1 hit
cd00063, FN3, 1 hit
cd12894, SPRY_PRY_TRIM36, 1 hit
Gene3Di2.60.120.920, 1 hit
2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR001870, B30.2/SPRY
IPR043136, B30.2/SPRY_sf
IPR003649, Bbox_C
IPR013320, ConA-like_dom_sf
IPR017903, COS_domain
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR013783, Ig-like_fold
IPR040859, Midline-1_COS
IPR035727, SPRY/PRY_TRIM36
IPR027726, Trim36
IPR027370, Znf-RING_LisH
IPR000315, Znf_B-box
IPR001841, Znf_RING
IPR017907, Znf_RING_CS
PANTHERiPTHR24099:SF18, PTHR24099:SF18, 1 hit
PfamiView protein in Pfam
PF18568, COS, 1 hit
PF00041, fn3, 1 hit
PF00643, zf-B_box, 1 hit
PF13445, zf-RING_UBOX, 1 hit
SMARTiView protein in SMART
SM00502, BBC, 1 hit
SM00336, BBOX, 1 hit
SM00184, RING, 1 hit
SUPFAMiSSF49265, SSF49265, 1 hit
SSF49899, SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS50188, B302_SPRY, 1 hit
PS51262, COS, 1 hit
PS50853, FN3, 1 hit
PS50119, ZF_BBOX, 1 hit
PS00518, ZF_RING_1, 1 hit
PS50089, ZF_RING_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH9GDA3_ANOCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H9GDA3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 16, 2012
Last sequence update: June 26, 2013
Last modified: October 7, 2020
This is version 63 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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Main funding by: National Institutes of Health

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