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UniProtKB - H9GD60 (H9GD60_ANOCA)

Entry version 62 (02 Dec 2020)
Sequence version 1 (16 May 2012)
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Protein

Poly [ADP-ribose] polymerase

Gene

TNKS2

Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosyltransferaseUniRule annotation, Transferase
LigandNADUniRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Poly [ADP-ribose] polymeraseUniRule annotation (EC:2.4.2.-UniRule annotation)
Short name:
PARPUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TNKS2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnolis carolinensis (Green anole) (American chameleon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri28377 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Iguania › Dactyloidae › Anolis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001646 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSACAG00000007762, Expressed in testis and 15 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		28377.ENSACAP00000007709

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini38 – 799ANK_REP_REGIONInterPro annotationAdd BLAST762
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati72 – 104ANKPROSITE-ProRule annotationAdd BLAST33
Repeati105 – 137ANKPROSITE-ProRule annotationAdd BLAST33
Repeati138 – 170ANKPROSITE-ProRule annotationAdd BLAST33
Repeati225 – 257ANKPROSITE-ProRule annotationAdd BLAST33
Repeati258 – 290ANKPROSITE-ProRule annotationAdd BLAST33
Repeati291 – 323ANKPROSITE-ProRule annotationAdd BLAST33
Repeati378 – 413ANKPROSITE-ProRule annotationAdd BLAST36
Repeati414 – 446ANKPROSITE-ProRule annotationAdd BLAST33
Repeati447 – 479ANKPROSITE-ProRule annotationAdd BLAST33
Repeati540 – 572ANKPROSITE-ProRule annotationAdd BLAST33
Repeati573 – 605ANKPROSITE-ProRule annotationAdd BLAST33
Repeati606 – 638ANKPROSITE-ProRule annotationAdd BLAST33
Repeati693 – 725ANKPROSITE-ProRule annotationAdd BLAST33
Repeati726 – 758ANKPROSITE-ProRule annotationAdd BLAST33
Repeati759 – 791ANKPROSITE-ProRule annotationAdd BLAST33
Domaini891 – 950SAMInterPro annotationAdd BLAST60
Domaini973 – 1178PARP catalyticInterPro annotationAdd BLAST206

Keywords - Domaini

ANK repeatPROSITE-ProRule annotation, RepeatARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4177, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159911

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_004303_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		H9GD60

Identification of Orthologs from Complete Genome Data

More...OMAi		ADWLDWR

Database of Orthologous Groups

More...OrthoDBi		111565at2759

TreeFam database of animal gene trees

More...TreeFami		TF326036

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.150.50, 1 hit
1.25.40.20, 5 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR012317, Poly(ADP-ribose)pol_cat_dom
IPR001660, SAM
IPR013761, SAM/pointed_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00023, Ank, 2 hits
PF12796, Ank_2, 5 hits
PF00644, PARP, 1 hit
PF07647, SAM_2, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01415, ANKYRIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00248, ANK, 15 hits
SM00454, SAM, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47769, SSF47769, 1 hit
SSF48403, SSF48403, 3 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 15 hits
PS51059, PARP_CATALYTIC, 1 hit
PS50105, SAM_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

H9GD60-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGRRGAGGA PGAPLGEALR PSSASCFGGV SSSSSFSEPA RELFEACRNG 
        60         70         80         90        100
DVERVKRLVR PENVNGRDTA GRKSSPLHFA AGFGRRDVVE YLLQSGANVH 
       110        120        130        140        150
ARDDGGLIPL HNACSFGHAE VVNLLLRHGA DPNSRDNWNY TPLHESAIKG 
       160        170        180        190        200
KIDVCIVLLQ HGADPAIRNT DGRTALDLAD PSAKAVLTGE YKKDELLESA 
       210        220        230        240        250
RSGNEEKLMA LLTPLNVNCH ASDGRKSTPL HLAAGYNRVK IVQLLLQHGA 
       260        270        280        290        300
DVHAKDKGDL VPLHNACSYG HYEVTELLVK HGACVNAMDL WQFTPLHEAA 
       310        320        330        340        350
SKNRVEVCSL LLSYGADPTL LNCHNKSTID LAPTPQLKER LAYEFKGHSL 
       360        370        380        390        400
LQAARESDVA RVKKHLSLEI VNFKHPQTHE TALHCAAASP YQKRKQVCEL 
       410        420        430        440        450
LLRKGANINE KTKDFLTPLH VASEKGHNDV IEVVVKHEAK VNALDNLGQT 
       460        470        480        490        500
SLHRAAHCGH LQTCRLLLSS GCDPSIVSLQ GFTASQMGNE SIQQLLQEGV 
       510        520        530        540        550
PLGNSEADRQ LLEAAKAGDM DTVKKLCTVQ SVNCRDIEGR QSTPLHFAAG 
       560        570        580        590        600
YNRVSVVEYL LQHGADVHAK DKGGLVPLHN ACSYGHYEVA ELLVKHGAVV 
       610        620        630        640        650
NVADLWKFTP LHEAAAKGKY EICKLLLQHG ADPTKKNRDG NTPLDLVKDG 
       660        670        680        690        700
DTDIQDLLRG DAALLDASKK GCLARVKKLC SPDNVNCRDT QGRHSTPLHL 
       710        720        730        740        750
AAGYNNLEVA EYLLQHGADV NAQDKGGLIP LHNAASYGHV DVAALLIKYH 
       760        770        780        790        800
ACVNATDKWA FTPLHEAAQK GRTQLCALVL AHGADPTLKN QEGQTPLDLV 
       810        820        830        840        850
TADDVSALLT AAMPLSALPS CYKPQVINVS QNTGSSADSL SSIPSSPSNL 
       860        870        880        890        900
SAASSLDNLS GSFSELSVVS ANGAEGAAGL EKKEVPGVDF SINQFVRNLG 
       910        920        930        940        950
LEHLIDIFER EQITLDILIE MGHKELKEIG INAYGHRHKI IKGIERLISG 
       960        970        980        990       1000
QQGLNTYLTL NTSGSGTILI DLSLDDKEFQ SVEEEMQSTV REHRDGGHAG 
      1010       1020       1030       1040       1050
GVFNRYNILK IQKVCNKKLW ERYTHRRKEV SEENHNHANE RMLFHGSPFV 
      1060       1070       1080       1090       1100
NAIIHKGFDE RHAYIGGMFG AGIYFAENSS KSNQYVYGIG GGTGCPIHKD 
      1110       1120       1130       1140       1150
RSCYVCHRHL LFCRVTLGKS FLQFSAMKMA HSPPGHHSVT GRPSVNGLAL 
      1160       1170       1180
AEYVIYRGEQ AYPEYLITYQ IVKPEPATEA
Length:1,180
Mass (Da):128,258
Last modified:May 16, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8F52B7C4DA7E805D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AAWZ02020145 Genomic DNA No translation available.

NCBI Reference Sequences

More...RefSeqi		XP_003223838.1, XM_003223790.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSACAT00000007874; ENSACAP00000007709; ENSACAG00000007762

Database of genes from NCBI RefSeq genomes

More...GeneIDi		100567928

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		acs:100567928

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAWZ02020145 Genomic DNA No translation available.
RefSeqiXP_003223838.1, XM_003223790.3

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi28377.ENSACAP00000007709

Genome annotation databases

EnsembliENSACAT00000007874; ENSACAP00000007709; ENSACAG00000007762
GeneIDi100567928
KEGGiacs:100567928

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		80351

Phylogenomic databases

eggNOGiKOG4177, Eukaryota
GeneTreeiENSGT00940000159911
HOGENOMiCLU_004303_0_0_1
InParanoidiH9GD60
OMAiADWLDWR
OrthoDBi111565at2759
TreeFamiTF326036

Gene expression databases

BgeeiENSACAG00000007762, Expressed in testis and 15 other tissues

Family and domain databases

Gene3Di1.10.150.50, 1 hit
1.25.40.20, 5 hits
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR012317, Poly(ADP-ribose)pol_cat_dom
IPR001660, SAM
IPR013761, SAM/pointed_sf
PfamiView protein in Pfam
PF00023, Ank, 2 hits
PF12796, Ank_2, 5 hits
PF00644, PARP, 1 hit
PF07647, SAM_2, 1 hit
PRINTSiPR01415, ANKYRIN
SMARTiView protein in SMART
SM00248, ANK, 15 hits
SM00454, SAM, 1 hit
SUPFAMiSSF47769, SSF47769, 1 hit
SSF48403, SSF48403, 3 hits
PROSITEiView protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 15 hits
PS51059, PARP_CATALYTIC, 1 hit
PS50105, SAM_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH9GD60_ANOCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H9GD60
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 16, 2012
Last sequence update: May 16, 2012
Last modified: December 2, 2020
This is version 62 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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