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Entry version 60 (10 Feb 2021)
Sequence version 1 (16 May 2012)
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Protein
Submitted name:

Collagen type V alpha 1 chain

Gene

COL5A1

Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionToxinARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Collagen type V alpha 1 chainImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:COL5A1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnolis carolinensis (Green anole) (American chameleon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri28377 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaIguaniaDactyloidaeAnolis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001646 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Linkage group LGg

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrixARBA annotation, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22Sequence analysisAdd BLAST22
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500361932623 – 1836Sequence analysisAdd BLAST1814

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSACAG00000007221, Expressed in hemipenis and 12 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
28377.ENSACAP00000007585

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1607 – 1835Fibrillar collagen NC1InterPro annotationAdd BLAST229

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni226 – 255DisorderedSequence analysisAdd BLAST30
Regioni295 – 324DisorderedSequence analysisAdd BLAST30
Regioni465 – 503DisorderedSequence analysisAdd BLAST39
Regioni555 – 1597DisorderedSequence analysisAdd BLAST1043

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi470 – 484Pro-richSequence analysisAdd BLAST15
Compositional biasi556 – 570PolarSequence analysisAdd BLAST15
Compositional biasi678 – 692Pro-richSequence analysisAdd BLAST15
Compositional biasi798 – 812PolyampholyteSequence analysisAdd BLAST15
Compositional biasi933 – 969Pro-richSequence analysisAdd BLAST37
Compositional biasi1152 – 1166PolyampholyteSequence analysisAdd BLAST15
Compositional biasi1317 – 1353Pro-richSequence analysisAdd BLAST37
Compositional biasi1377 – 1392Pro-richSequence analysisAdd BLAST16
Compositional biasi1419 – 1434Pro-richSequence analysisAdd BLAST16
Compositional biasi1450 – 1464Pro-richSequence analysisAdd BLAST15
Compositional biasi1521 – 1536Pro-richSequence analysisAdd BLAST16
Compositional biasi1573 – 1594PolarSequence analysisAdd BLAST22

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3544, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159211

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001074_2_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
H9GD05

Identification of Orthologs from Complete Genome Data

More...
OMAi
SKMAKWP

TreeFam database of animal gene trees

More...
TreeFami
TF323987

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008160, Collagen
IPR013320, ConA-like_dom_sf
IPR000885, Fib_collagen_C
IPR001791, Laminin_G

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01410, COLFI, 1 hit
PF01391, Collagen, 7 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00038, COLFI, 1 hit
SM00282, LamG, 1 hit
SM00210, TSPN, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49899, SSF49899, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51461, NC1_FIB, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

H9GD05-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
PEKQPVRLLI SLLFPLFFPA EPADLLKVLD FHNLPDGISK TTGFCTSRRS
60 70 80 90 100
SKGADVAYRV TKDAQLSAPT KQLYPDTASP FPEDFSILTT VKAKKGSQSF
110 120 130 140 150
LLSIYNEQGI QQIGMEMGRS PVFLYEDHTG KPGPEDYPLF RGINLSDGKW
160 170 180 190 200
HRIAISVHQK NVTLILDCKK KITKFLDRSD HPIIDVNGII VFGTRILDEE
210 220 230 240 250
VFEGDIQQLL LVSDHRAAYD YCEHYSPDCD TAVPDSPQSQ DPSPDEYYTD
260 270 280 290 300
GDGNLEAEGE TYYYEYPYYE DTDDTGKAIP PTTQPVEIEE VARERTETTE
310 320 330 340 350
EVAPPATQPP PVVESTLEEN KEDEKVDDPL VDEYNYEPLP DEYYTPLPYE
360 370 380 390 400
DLNYEDIDNL DKFTEEGVEA EVPTSTVITY NETDAIATRN EDEDVDKDFT
410 420 430 440 450
VDTIKEYEDG YYDVGDYDRT DSPDIGPGMP ANQDTIYEGI GGPRGEKGQK
460 470 480 490 500
GEPAIIEPGM LIEGPSGPEG PAGLPGPPGT TGPMGPVGDP GERGPPGRAG
510 520 530 540 550
LPGADGLPGP PGTMLMLPFR FSGGGDGGSK GPMVSAQESQ AQAILQQARL
560 570 580 590 600
AKRLQRSPMQ PNTANTGFWG PPGSTGIKGE SGDMGPQGPR GVQGPPGPSG
610 620 630 640 650
KPGRRGRAGS DGARGMPGQT GPKGDRGFDG LAGLPGEKGH RGDSGPSGPP
660 670 680 690 700
GAPGEDGDRG DDGEVGPRGL PGEPGPRGLL GPKGPPGPSG PPGIAGMDGQ
710 720 730 740 750
SGPKGNVGPQ GEPGPPGQQG NPGAQGLPGP QGAIGPPGDK GPLGKPGLPG
760 770 780 790 800
MPGADGPPGH PGKEGPSGEK GSQGPAGPQG PIGYPGPRGV KGADGVRGLK
810 820 830 840 850
GTKGEKGEDG FPGFKGDMGI KGDRGEIGPP GPRGEDGPEG PKGRGGPNGE
860 870 880 890 900
PGPLGPSGEK GKLGVPGLPG YPGRIGPKGS TGFPGFPGAN GEKGTRGTPG
910 920 930 940 950
KPGPRGQRGP TGPRGERGQR GITGKPGPKG NSGGDGPPGP PGERGPPGTQ
960 970 980 990 1000
GPTGFPGPKG PPGPPGKDGL PGHPGQRGET GFQGKTGPPG PPGVVGPQGP
1010 1020 1030 1040 1050
TGETGPMGER GHPGPPGPPG EQGLPGLAGK EGTKGDPGPA GLPGKDGPAG
1060 1070 1080 1090 1100
LRGFPGDRGL PGPIGPVGLK GNEGPPGPPG PAGSPGERGP AGAAGPIGLP
1110 1120 1130 1140 1150
GRPGPQGPPG PAGEKGAPGE KGPQGPAGRD GIQGPVGLPG PAGPVGPPGE
1160 1170 1180 1190 1200
DGDKGEIGEP GQKGSKGDKG EQGPPGPTGP QGQIGQPGPA GADGEPGPRG
1210 1220 1230 1240 1250
QQGLFGQKGD EGSRGFPGPP GPVGLQGLPG PPGEKGETGD VGQMGPPGPP
1260 1270 1280 1290 1300
GPRGPSGSPG ADGPQGPPGG IGNPGAVGEK GEPGESGEPG LPGDGGPPGP
1310 1320 1330 1340 1350
KGERGEKGEA GPSGAAGPPG PKGPPGDDGP KGSPGPVGFP GDPGPPGEPG
1360 1370 1380 1390 1400
PAGQDGPPGD KGDDGESGQT GSPGPTGEPG PSGPPGKRGP PGPAGPEGRQ
1410 1420 1430 1440 1450
GEKGAKGEGG LEGPPGKTGP VGPQGPPGKP GPDGLRGIPG PVGEQGLPGA
1460 1470 1480 1490 1500
PGPDGPPGPM GPPGLPGLKG DSGPKGEKGH PGLIGLIGPP GEQGEKGDRG
1510 1520 1530 1540 1550
LPGPQGGSGA KGEQGIAGPS GPIGPPGPPG LPGPPGPKGA KGSSGPTGQK
1560 1570 1580 1590 1600
GEMGHPGLPG PPGPPGEVIQ PLPIQSSKRT RRNIDASQLV DDAPNTDNYM
1610 1620 1630 1640 1650
DYADGMEEIF GSLNSLKLEI EQMKHPLGTQ HNPARTCKDL QLCHPDFPDG
1660 1670 1680 1690 1700
EYWVDPNQGC SRDSFKVYCN FTAGGETCIF PDKKSEGARI TSWPKENPGS
1710 1720 1730 1740 1750
WFSEFKRGKL LSYVDSEGNP IGVVQMTFLR LLTASAHQNI TYNCYQSVAW
1760 1770 1780 1790 1800
HDDASGNYDK AIRFLGSNDE EMSYDNNPFI RAVLDGCAAR KGYQKTVLEI
1810 1820 1830
NTPKVEQIPI VDIMFNDFGE ASQKFGFEVG PACFMG
Length:1,836
Mass (Da):185,043
Last modified:May 16, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i55D0C513C1C0EEF0
GO

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSACAT00000007746; ENSACAP00000007585; ENSACAG00000007221

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi28377.ENSACAP00000007585

Genome annotation databases

EnsembliENSACAT00000007746; ENSACAP00000007585; ENSACAG00000007221

Phylogenomic databases

eggNOGiKOG3544, Eukaryota
GeneTreeiENSGT00940000159211
HOGENOMiCLU_001074_2_1_1
InParanoidiH9GD05
OMAiSKMAKWP
TreeFamiTF323987

Gene expression databases

BgeeiENSACAG00000007221, Expressed in hemipenis and 12 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR008160, Collagen
IPR013320, ConA-like_dom_sf
IPR000885, Fib_collagen_C
IPR001791, Laminin_G
PfamiView protein in Pfam
PF01410, COLFI, 1 hit
PF01391, Collagen, 7 hits
SMARTiView protein in SMART
SM00038, COLFI, 1 hit
SM00282, LamG, 1 hit
SM00210, TSPN, 1 hit
SUPFAMiSSF49899, SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS51461, NC1_FIB, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH9GD05_ANOCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H9GD05
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 16, 2012
Last sequence update: May 16, 2012
Last modified: February 10, 2021
This is version 60 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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