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Entry version 57 (07 Oct 2020)
Sequence version 2 (26 Jun 2013)
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Protein
Submitted name:

Uncharacterized protein

Gene

setd1a

Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulatorARBA annotation, MethyltransferaseARBA annotation, RNA-bindingPROSITE-ProRule annotation, Transferase
LigandS-adenosyl-L-methionineARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:setd1aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnolis carolinensis (Green anole) (American chameleon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri28377 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaIguaniaDactyloidaeAnolis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001646 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSACAG00000007606, Expressed in embryonic post-anal tail and 14 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
28377.ENSACAP00000007457

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini80 – 168RRMInterPro annotationAdd BLAST89
Domaini1754 – 1871SETInterPro annotationAdd BLAST118
Domaini1877 – 1893Post-SETInterPro annotationAdd BLAST17

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni187 – 345DisorderedSequence analysisAdd BLAST159
Regioni424 – 462DisorderedSequence analysisAdd BLAST39
Regioni482 – 513DisorderedSequence analysisAdd BLAST32
Regioni569 – 596DisorderedSequence analysisAdd BLAST28
Regioni875 – 1139DisorderedSequence analysisAdd BLAST265
Regioni1212 – 1277DisorderedSequence analysisAdd BLAST66
Regioni1294 – 1319DisorderedSequence analysisAdd BLAST26
Regioni1338 – 1366DisorderedSequence analysisAdd BLAST29
Regioni1410 – 1443DisorderedSequence analysisAdd BLAST34
Regioni1510 – 1591DisorderedSequence analysisAdd BLAST82

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi214 – 293PolarSequence analysisAdd BLAST80
Compositional biasi308 – 345PolarSequence analysisAdd BLAST38
Compositional biasi482 – 500PolyampholyteSequence analysisAdd BLAST19
Compositional biasi892 – 934PolyampholyteSequence analysisAdd BLAST43
Compositional biasi968 – 986PolyampholyteSequence analysisAdd BLAST19
Compositional biasi1010 – 1037PolarSequence analysisAdd BLAST28
Compositional biasi1072 – 1088PolarSequence analysisAdd BLAST17
Compositional biasi1089 – 1106AcidicSequence analysisAdd BLAST18
Compositional biasi1110 – 1129PolarSequence analysisAdd BLAST20
Compositional biasi1229 – 1243PolyampholyteSequence analysisAdd BLAST15
Compositional biasi1261 – 1277PolyampholyteSequence analysisAdd BLAST17
Compositional biasi1540 – 1560AcidicSequence analysisAdd BLAST21

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1080, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162290

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001226_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
H9GCU8

TreeFam database of animal gene trees

More...
TreeFami
TF106436

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12548, RRM_Set1A, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.70.330, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR024657, COMPASS_Set1_N-SET
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR003616, Post-SET_dom
IPR035979, RBD_domain_sf
IPR000504, RRM_dom
IPR034467, Set1A_RRM
IPR001214, SET_dom
IPR037841, SETD1A

The PANTHER Classification System

More...
PANTHERi
PTHR45814:SF3, PTHR45814:SF3, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF11764, N-SET, 1 hit
PF00076, RRM_1, 1 hit
PF00856, SET, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01291, N-SET, 1 hit
SM00508, PostSET, 1 hit
SM00360, RRM, 1 hit
SM00317, SET, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54928, SSF54928, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50868, POST_SET, 1 hit
PS50102, RRM, 1 hit
PS50280, SET, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

H9GCU8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDQEGGGDFQ KTPNFQWRNY KLIVDPVLKR APHKIYRYDG VHFSASDSGY
60 70 80 90 100
EPVNEVRDPR RRIWSKTRDL SLPVPKFKLD EFYVGQIPLK EVTFARLNDN
110 120 130 140 150
IKEPFLAEMC KKYGDIEEIE ILYNPKNRKH LGLAKVLFTS TRGAKETVKN
160 170 180 190 200
LHNTTVMGNI IHAQLDIKGQ QRMKYYELIV NGSYTPQTVP TGGKILNEKF
210 220 230 240 250
PVDSSESRRR HSTDSSYPSS VMPSTPGNGT PCSQDTPYSS GRQDTPSSYG
260 270 280 290 300
QYTPQSSQGT PYTPRGGTPY SQDSAYSSRQ GTPGYSTYQS ESTSYKSRRH
310 320 330 340 350
ENSFSDSYSR RHYSSSSSSS SSSSSTTSSS SHYRSNDHHY PPFNAAQFQN
360 370 380 390 400
SHSFAQQSTE LFPAPSVLYP SYVATPEPFP TPAESLPADQ DYRLLPTAET
410 420 430 440 450
FAANSLPPTE FLAQETKENI NPVPTAALGV NDQSHSPAGQ TSPARSGSPV
460 470 480 490 500
PETTNESVPF AHHSSLDSRI EMLLKEQRSK FSFLNSDTEE EEEEKGGPKG
510 520 530 540 550
AEPHGPCTPP PPLPVSFEDV VPALDMVSGA ESPKANGQDR ETNIQSQLAV
560 570 580 590 600
LEASLTADSP PIVLLNKASQ HSSGEDMEIS DDEAEVEPPT PVTGVPEPHF
610 620 630 640 650
SMMPSALGHM PMGMSSFTPH HQPELPPTYP IQPLIPSREI PSVTQLQPDF
660 670 680 690 700
RGRGGMVGGG RGAPHIYDFV NSMELMNRLG NQWGGMPMSF QMQTQMLSRL
710 720 730 740 750
QQMRQSKGQF EDPFSYHREA AAFCGQPLYD QPPLPPPQPL LDFRGTPWGY
760 770 780 790 800
QEEVPLPPPL PKDPHSSVVD SVLETLMQEM KSIMQRDLNR KMVENVAFST
810 820 830 840 850
FDKWWERKEE KVKPFQSAVK QPAKEEEKDK TKLKEPALLS LVDWAKSGGT
860 870 880 890 900
GGLEGFGFGG GFRGVLGLPS FKVKRKEPSE ISEGSEVKQP RPSTPIEEDE
910 920 930 940 950
DDKESSQIHK PSKRDDERIK GTGKRRKLFC LDSEGEEASD DSSSEKLLSA
960 970 980 990 1000
SQCVVASPYG PASTEPDEEE EEQRRQKNEA SREQSAKASE VLENSCGPRG
1010 1020 1030 1040 1050
LKKSKHCSSL QKADPGNDTS VSLGGEVSSS GWLQREGGQL SSGGALDDGE
1060 1070 1080 1090 1100
SDSSSKCSLY EDSDEDGDST SDSESSSSSS SSLSSSSSSS DEEEEEEEEE
1110 1120 1130 1140 1150
AESMEEMDGS AMNSCPSEST RSTEEVEQQA TNAEMDKKKP EAALLQGEMH
1160 1170 1180 1190 1200
SSWFSFGVVL WMLSSMLYDR HFPTLLSSLL FIGSLKMILK NCSISPKGLR
1210 1220 1230 1240 1250
AVSDIGLVAE EKPAPQEDSM QIPLPEEKDV GTALEERPRP EERPSSPIPL
1260 1270 1280 1290 1300
LPPPKKRRKT VSFSAPGEED ETKGALEKPP ELAHPALLPA PLPPIPSTPT
1310 1320 1330 1340 1350
DEAQSPLVPV EPMLPPQVSL SSDAPATVAC SLPPVTFPVK PAPAAGRKRE
1360 1370 1380 1390 1400
SPKASQRTIS NLPADHASMV KYHLRVPPPP EEKGLQVREQ MGASSLLELA
1410 1420 1430 1440 1450
NQPHRAMLAL KRPAGARGDD SEETEISDET EESKAAVPPP PTLSLEASSI
1460 1470 1480 1490 1500
LMEHNYAMAV RAAPAAASRK ADEASIDLLR VDLYNEQMGE ILEAPEEVVA
1510 1520 1530 1540 1550
DATEIKTEPE LSDLVALPLP PPLPTEKPKA TVREQQQSQN SEEEEEDEEE
1560 1570 1580 1590 1600
EDEEEESADS SDEGEIRRRS LRSHSHKYAP AKPPPPPPVF ETRSEFEQMT
1610 1620 1630 1640 1650
ILYDIWNSGL DLEDMKYLRL TYERLLHEDN STDWLNDTHW VHHTITNIAN
1660 1670 1680 1690 1700
PKRKRKSSDL REHQTGCARS EGYYHISKKE KDKYLDVCPA TVQQLDAPDT
1710 1720 1730 1740 1750
QAVMFNNLPF PPQGTNRILS ERRSEQRRLL SAIGSFAILD SDLLKLNQLK
1760 1770 1780 1790 1800
FRKKKLRFGR SRIHEWGLFA MEPIAADEMV IEYVGQNIRQ VVADMREKRY
1810 1820 1830 1840 1850
AQQGIGSSYL FRVDHDTIID ATKCGNLARF INHCCTPNCY AKVITIESQK
1860 1870 1880 1890
KIVIYSKQPI SINEEITYDY KFPIEENKIP CLCGTENCRG TLN
Length:1,893
Mass (Da):209,785
Last modified:June 26, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i576E4476EA9F4F41
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAWZ02020207 Genomic DNA No translation available.
AAWZ02020208 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSACAT00000007614; ENSACAP00000007457; ENSACAG00000007606

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAWZ02020207 Genomic DNA No translation available.
AAWZ02020208 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi28377.ENSACAP00000007457

Genome annotation databases

EnsembliENSACAT00000007614; ENSACAP00000007457; ENSACAG00000007606

Phylogenomic databases

eggNOGiKOG1080, Eukaryota
GeneTreeiENSGT00940000162290
HOGENOMiCLU_001226_0_0_1
InParanoidiH9GCU8
TreeFamiTF106436

Gene expression databases

BgeeiENSACAG00000007606, Expressed in embryonic post-anal tail and 14 other tissues

Family and domain databases

CDDicd12548, RRM_Set1A, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR024657, COMPASS_Set1_N-SET
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR003616, Post-SET_dom
IPR035979, RBD_domain_sf
IPR000504, RRM_dom
IPR034467, Set1A_RRM
IPR001214, SET_dom
IPR037841, SETD1A
PANTHERiPTHR45814:SF3, PTHR45814:SF3, 2 hits
PfamiView protein in Pfam
PF11764, N-SET, 1 hit
PF00076, RRM_1, 1 hit
PF00856, SET, 1 hit
SMARTiView protein in SMART
SM01291, N-SET, 1 hit
SM00508, PostSET, 1 hit
SM00360, RRM, 1 hit
SM00317, SET, 1 hit
SUPFAMiSSF54928, SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50868, POST_SET, 1 hit
PS50102, RRM, 1 hit
PS50280, SET, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH9GCU8_ANOCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H9GCU8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 16, 2012
Last sequence update: June 26, 2013
Last modified: October 7, 2020
This is version 57 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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