Bardet-Biedl syndrome 2 protein homolog

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• RNA polymerase II repressing transcription factor binding Source: Ensembl

GO - Biological processⁱ

• adult behavior Source: Ensembl
• artery smooth muscle contraction Source: Ensembl
• brain morphogenesis Source: Ensembl
• cartilage development Source: Ensembl
• cerebral cortex development Source: Ensembl
• cilium assembly Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• fat cell differentiation Source: Ensembl
• Golgi to plasma membrane protein transport Source: Ensembl
• hippocampus development Source: Ensembl
• negative regulation of appetite by leptin-mediated signaling pathway Source: Ensembl
• negative regulation of gene expression Source: Ensembl
• negative regulation of multicellular organism growth Source: Ensembl
• non-motile cilium assembly Source: Ensembl
• photoreceptor cell maintenance Source: Ensembl
• positive regulation of multicellular organism growth Source: Ensembl
• protein localization to organelle Source: Ensembl
• regulation of cilium beat frequency involved in ciliary motility Source: Ensembl
• sperm axoneme assembly Source: Ensembl
• striatum development Source: Ensembl
• vasodilation Source: Ensembl
• visual perception Source: Ensembl

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componentⁱ

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• RNA polymerase II repressing transcription factor binding Source: Ensembl

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Coiled coil

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MLVPVFTLKL SHKILPRMVA LGKYDGVHPC LTAATQAGKV FIHNPHARSQ 
        60         70         80         90        100
RVNANRLVLS TQDADISLLN INEAVSCLTA GVLNPDLDCD SLLVGTRTSL 
       110        120        130        140        150
LAYDVHNNAD LFYAGVPDGA NTIVLGTLGD MPSPLAIIGG NCSLQGFNHE 
       160        170        180        190        200
GKDLFWTVTG DNVRSLALCD FDADGKKELL VGSEDFDIRV FKEDEIVAEM 
       210        220        230        240        250
SETETVTSLT SMCSSHFGYA LSNGTVGIYN RTSRYWRIKS KNQAMSIHAF 
       260        270        280        290        300
DINSDGVCEL ITGWSSGKID ARSDRTGEVI FKDNFASSVA GIVEGDYRMD 
       310        320        330        340        350
GNTQLICCSV DGEVRGYLPG SQESKGKLLD TSVDQDLIRE LSQKKQNLLL 
       360        370        380        390        400
ELRNYEENAK QVELNTQVNE ADGQKGVIPA NTQLQTALSV NLGSDSESAH 
       410        420        430        440        450
VELRISTSND TIIRAVLIFA EGIFEGESHV IHPSLQNLSS CIRVPLTPPK 
       460        470        480        490        500
DVPVELNIKA FVGYRNSTQF HVFELSRQLP RFSMYTLSSP DSAPGPLSFV 
       510        520        530        540        550
RFTLNERVQM IVMWLKQSFL LPEDLEIQNV SFEVCFTSLR DAGQLWIKMT 
       560        570        580        590        600
PGGEISINTD NVDLAGDIVQ SMASFWAIED LQVEADFPAY FEEMRKALVV 
       610        620        630        640        650
VDNSHAVCQK LTANMADSSN LIRSVLVRAE DSRLMGDMKN MKRRYMELYD 
       660        670        680        690        700
LNRDLLSQYK IRCSNHTELL NNLKAINQAI QRAGQLRVGK PKAQVIAACR 
       710        720 
DAIKNNSVNM LIKIMRVGTL SS                               

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ