UniProtKB - H9GC29 (H9GC29_ANOCA)
Protein
Phospholipid scramblase
Gene
PLSCR5
Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Functioni
May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.UniRule annotation
Cofactori
Ca2+UniRule annotation
GO - Molecular functioni
- phospholipid scramblase activity Source: GO_Central
GO - Biological processi
- plasma membrane phospholipid scrambling Source: GO_Central
Keywordsi
Ligand | CalciumUniRule annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Phospholipid scramblaseUniRule annotation |
Gene namesi | Name:PLSCR5Imported |
Organismi | Anolis carolinensis (Green anole) (American chameleon)Imported |
Taxonomic identifieri | 28377 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Iguania › Dactyloidae › Anolis |
Proteomesi |
|
Subcellular locationi
Plasma Membrane
- plasma membrane Source: GO_Central
Expressioni
Gene expression databases
Bgeei | ENSACAG00000006915, Expressed in brain and 7 other tissues |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 30 | DisorderedSequence analysisAdd BLAST | 30 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0621, Eukaryota |
GeneTreei | ENSGT00940000161728 |
HOGENOMi | CLU_053024_2_0_1 |
InParanoidi | H9GC29 |
OrthoDBi | 1015148at2759 |
TreeFami | TF314939 |
Family and domain databases
InterProi | View protein in InterPro IPR005552, Scramblase IPR025659, Tubby-like_C |
PANTHERi | PTHR23248, PTHR23248, 1 hit |
Pfami | View protein in Pfam PF03803, Scramblase, 1 hit |
SUPFAMi | SSF54518, SSF54518, 1 hit |
i Sequence
Sequence statusi: Complete.
H9GC29-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MESRDQTQKD TLGPVYKTIQ EPLPGSPDPP DLAKLSETAI TWKPAQPPGT
60 70 80 90 100
LPPGLESLKQ LDQIIIHQQV ELLQVILGTE TCSKYEIKNC MGQRVYFAVE
110 120 130 140 150
ENGCFDRNFC SPLRSFTMRI TDNTGQEVIT VNRPLRCNSC WFPCYLQEVE
160 170 180 190 200
VQSPPGTTVG YVVQKWDPLL PKFTIRNESN EDVLKIIGPY GTCGCFGDVD
210 220 230 240 250
FEVKSLTDMS TIGKISKYWS GFVNNIFTNT ANFGIQVPVD LDVKIKAVMI
260
GACFLLDLMF FENSLDGL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAWZ02027844 Genomic DNA No translation available. |
RefSeqi | XP_003227040.1, XM_003226992.3 XP_008118267.1, XM_008120060.2 XP_008118270.1, XM_008120063.2 XP_008118271.1, XM_008120064.2 XP_016852662.1, XM_016997173.1 XP_016852663.1, XM_016997174.1 |
Genome annotation databases
Ensembli | ENSACAT00000006923; ENSACAP00000006775; ENSACAG00000006915 |
GeneIDi | 100558430 |
KEGGi | acs:100558430 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAWZ02027844 Genomic DNA No translation available. |
RefSeqi | XP_003227040.1, XM_003226992.3 XP_008118267.1, XM_008120060.2 XP_008118270.1, XM_008120063.2 XP_008118271.1, XM_008120064.2 XP_016852662.1, XM_016997173.1 XP_016852663.1, XM_016997174.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000006775 |
Genome annotation databases
Ensembli | ENSACAT00000006923; ENSACAP00000006775; ENSACAG00000006915 |
GeneIDi | 100558430 |
KEGGi | acs:100558430 |
Phylogenomic databases
eggNOGi | KOG0621, Eukaryota |
GeneTreei | ENSGT00940000161728 |
HOGENOMi | CLU_053024_2_0_1 |
InParanoidi | H9GC29 |
OrthoDBi | 1015148at2759 |
TreeFami | TF314939 |
Gene expression databases
Bgeei | ENSACAG00000006915, Expressed in brain and 7 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR005552, Scramblase IPR025659, Tubby-like_C |
PANTHERi | PTHR23248, PTHR23248, 1 hit |
Pfami | View protein in Pfam PF03803, Scramblase, 1 hit |
SUPFAMi | SSF54518, SSF54518, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | H9GC29_ANOCA | |
Accessioni | H9GC29Primary (citable) accession number: H9GC29 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 16, 2012 |
Last sequence update: | June 26, 2013 | |
Last modified: | August 12, 2020 | |
This is version 43 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |