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Entry version 57 (07 Oct 2020)
Sequence version 1 (16 May 2012)
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Protein
Submitted name:

Uncharacterized protein

Gene

DSCAML1

Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DSCAML1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnolis carolinensis (Green anole) (American chameleon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri28377 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaIguaniaDactyloidaeAnolis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001646 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1425 – 1445HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSACAG00000006694, Expressed in brain and 10 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
28377.ENSACAP00000006773

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini58 – 138Ig-likeInterPro annotationAdd BLAST81
Domaini146 – 234Ig-likeInterPro annotationAdd BLAST89
Domaini240 – 333Ig-likeInterPro annotationAdd BLAST94
Domaini338 – 417Ig-likeInterPro annotationAdd BLAST80
Domaini428 – 517Ig-likeInterPro annotationAdd BLAST90
Domaini522 – 616Ig-likeInterPro annotationAdd BLAST95
Domaini620 – 717Ig-likeInterPro annotationAdd BLAST98
Domaini719 – 816Fibronectin type-IIIInterPro annotationAdd BLAST98
Domaini821 – 920Fibronectin type-IIIInterPro annotationAdd BLAST100
Domaini925 – 1022Fibronectin type-IIIInterPro annotationAdd BLAST98
Domaini1026 – 1121Fibronectin type-IIIInterPro annotationAdd BLAST96
Domaini1111 – 1200Ig-likeInterPro annotationAdd BLAST90
Domaini1216 – 1310Fibronectin type-IIIInterPro annotationAdd BLAST95
Domaini1311 – 1411Fibronectin type-IIIInterPro annotationAdd BLAST101

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1548 – 1574DisorderedSequence analysisAdd BLAST27
Regioni1613 – 1637DisorderedSequence analysisAdd BLAST25
Regioni1673 – 1695DisorderedSequence analysisAdd BLAST23
Regioni1809 – 1832DisorderedSequence analysisAdd BLAST24
Regioni1857 – 1912DisorderedSequence analysisAdd BLAST56

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1447 – 1467Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1559 – 1574PolarSequence analysisAdd BLAST16
Compositional biasi1883 – 1912PolarSequence analysisAdd BLAST30

Keywords - Domaini

Coiled coilSequence analysis, Immunoglobulin domainARBA annotation, RepeatARBA annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3510, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155354

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001038_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
H9GC28

Identification of Orthologs from Complete Genome Data

More...
OMAi
TMDSAKH

TreeFam database of animal gene trees

More...
TreeFami
TF316846

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063, FN3, 6 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 15 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR033029, DSCAML1
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR013098, Ig_I-set
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR013106, Ig_V-set

The PANTHER Classification System

More...
PANTHERi
PTHR13817:SF54, PTHR13817:SF54, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00041, fn3, 5 hits
PF07679, I-set, 6 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060, FN3, 6 hits
SM00409, IG, 8 hits
SM00408, IGc2, 8 hits
SM00406, IGv, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726, SSF48726, 8 hits
SSF49265, SSF49265, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853, FN3, 6 hits
PS50835, IG_LIKE, 8 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

H9GC28-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
LPENRFFITF YGGLYISDVQ KEDALSTYRC ITKHKYSGET RQSNGARLSV
60 70 80 90 100
SDPAESIPTI LDGFHSREAK AGQLVELPCI ASGYPNPAIR WIKDGRPLPA
110 120 130 140 150
DSRWTKRLTG LTISDLRVED SGMYICEVTN TFGSAEVTGT LMVIDPLHVT
160 170 180 190 200
LTPKKLKTGI GSTVILSCAL SGSPEFAVRW YRNTELVTPD DFISLRGINN
210 220 230 240 250
ETLLITAAQK GHSGAYQCFA IRKAQTAQDF ATIVLEDGTP RIVSSFSEKV
260 270 280 290 300
VNPGEQFSLM CAAKGAPPPT ITWALDDEAI QRDGSHRTNQ YTMSDGTTVS
310 320 330 340 350
HMNITSPQIR DGGVYRCAAR NSVGSAEYQA RINVRGLPSI RGMKNITAVP
360 370 380 390 400
GDSFINCRVI GYPYYSIKWY KDSLLLPDNH RQVVFENGTL KLMDVQKGMD
410 420 430 440 450
EGEYLCSVLI QPQLSISQSV HVTVKAVPPL IQPFEFPPAS IGQLLYIPCV
460 470 480 490 500
VSSGDMPIRI TWRKDGQVII SGSGVTIESK EFMSSLQISS VSLKHNGNYT
510 520 530 540 550
CIASNDAASV SRERQLIVRV PPRFVVQPNN QDGIYGKAGV LNCSVDGYPP
560 570 580 590 600
PKVMWKHAKG SGNPQQYHPV PLTGRIQILP NSSLLIRHVL EEDIGYYLCQ
610 620 630 640 650
ASNGVGTDIS KSMFLTVKIP AMITSHPNTT IAIKGQGKEL NCTARGERPI
660 670 680 690 700
IIRWEKGDTV IDPDRNIRYA ISTKDNGDEV ISTLKLKPAD RGDSVFFSCH
710 720 730 740 750
AINSYGEDRG LIQLTVQEPP DPPELEIREV KARSMNLRWT QRFDGNSIIT
760 770 780 790 800
GFDIEYKNKS DSWDFKQSTR NISPTINQAN IVDLHPASVY SIRMYSFNKI
810 820 830 840 850
GRSEPSKELT ISTEEAAPDG PPMDVTLQPM TSQSIQVTWK APKKELQNGV
860 870 880 890 900
IRGYQIGYRE NSPGSNGQYS IVEMKATGDS EVYTLDNLKK FAQYGVVVQA
910 920 930 940 950
FNRAGTGPSS SEINATTLED VPSQPPENVR ALSITSDVAV ISWSEPPRST
960 970 980 990 1000
LNGVLKGYRV IFWSLYMDDK EWGEMQNITT VRERAELRGL EKFTNYSVQV
1010 1020 1030 1040 1050
LAYTQAGDGV RSNVLHIQTK EDIPGPPAGI KAVPSSASSV VVSWLPPTKP
1060 1070 1080 1090 1100
NGVIRKYTIF CSSPGSGQPA PSEYETSPEQ LFYRIAHLNR GQQYLLWVAA
1110 1120 1130 1140 1150
VTSAGRGNLS EKVTIEPAGK APAKIISFGG TVTTPWMKDV RLPCNSVGEP
1160 1170 1180 1190 1200
TPAVRWTKDS DDSAIPVAMD GHRQIQGNGT MILRSVKAED SGYYTCTATN
1210 1220 1230 1240 1250
TWGFDTIIVN LLVQVPPDQP RLTVSKTSAS SITLAWIPGD NGGSSIRGFV
1260 1270 1280 1290 1300
LQYSVDNSEE WKDVFIASSE RSFKLESLKC GTWYKVKLAA KNSVGAGRIS
1310 1320 1330 1340 1350
EIIEAKTHGR EPSFNKDQHL FTHINSTHAR LNLQGWNSGG CPILAIALDF
1360 1370 1380 1390 1400
RPKGTWAWQS LRANYSNEVF LTELREATWY ELRMKACNSA GCGNETMQFA
1410 1420 1430 1440 1450
TLDYDGSTIP PIKSAQGEGD DVKKLFTIAC PVILATLGVA LLFVVRKKRK
1460 1470 1480 1490 1500
EKRLKRLRDA KSLAEMLISK NNRSFDTPVK GPPQGPRLHI DIPRVQLLIE
1510 1520 1530 1540 1550
DKEGIKQIGD DKATIPVTDT EFNQAVNPQS FCTGVSLHHP ALIQNTGPLI
1560 1570 1580 1590 1600
DMSDIRPGTN PVSRKSVKSA HSTRNRYSSQ WTLTKCQAST PARTLTSDWR
1610 1620 1630 1640 1650
TVGSQHGITV TESDSYSASL SQDTDKGRNS MVSTESASST YEELARAYEH
1660 1670 1680 1690 1700
AKLEEQLQHA KFEITECFIS DSSSDQMTTG TNENADSMTS MSTPSEPGIC
1710 1720 1730 1740 1750
RFTASPPKPQ DSDRGKGVAV PIPHRANKSD YCNLPLYMKS ETFFRKPDLH
1760 1770 1780 1790 1800
EPCPVVPPRE ASIRNLARAY HSQAARHLTL DSGGASGGGG GSGGNKTVVV
1810 1820 1830 1840 1850
PHASAATTTL PQRTLAMPGP PGATAPSAPS APVAAAPTIT APAIAATAPA
1860 1870 1880 1890 1900
SVPISAPAAA TAPTPAPAAE SRLPHQTKMG GSRDSLLEMS TSGLSRSQKP
1910
GAGAYSKSYT LV
Length:1,912
Mass (Da):208,497
Last modified:May 16, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFAE96B6D98658D67
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAWZ02029620 Genomic DNA No translation available.
AAWZ02029621 Genomic DNA No translation available.
AAWZ02029622 Genomic DNA No translation available.
AAWZ02029623 Genomic DNA No translation available.
AAWZ02029624 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSACAT00000006921; ENSACAP00000006773; ENSACAG00000006694

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAWZ02029620 Genomic DNA No translation available.
AAWZ02029621 Genomic DNA No translation available.
AAWZ02029622 Genomic DNA No translation available.
AAWZ02029623 Genomic DNA No translation available.
AAWZ02029624 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi28377.ENSACAP00000006773

Genome annotation databases

EnsembliENSACAT00000006921; ENSACAP00000006773; ENSACAG00000006694

Phylogenomic databases

eggNOGiKOG3510, Eukaryota
GeneTreeiENSGT00940000155354
HOGENOMiCLU_001038_0_1_1
InParanoidiH9GC28
OMAiTMDSAKH
TreeFamiTF316846

Gene expression databases

BgeeiENSACAG00000006694, Expressed in brain and 10 other tissues

Family and domain databases

CDDicd00063, FN3, 6 hits
Gene3Di2.60.40.10, 15 hits
InterProiView protein in InterPro
IPR033029, DSCAML1
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR013098, Ig_I-set
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR013106, Ig_V-set
PANTHERiPTHR13817:SF54, PTHR13817:SF54, 1 hit
PfamiView protein in Pfam
PF00041, fn3, 5 hits
PF07679, I-set, 6 hits
SMARTiView protein in SMART
SM00060, FN3, 6 hits
SM00409, IG, 8 hits
SM00408, IGc2, 8 hits
SM00406, IGv, 2 hits
SUPFAMiSSF48726, SSF48726, 8 hits
SSF49265, SSF49265, 3 hits
PROSITEiView protein in PROSITE
PS50853, FN3, 6 hits
PS50835, IG_LIKE, 8 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH9GC28_ANOCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H9GC28
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 16, 2012
Last sequence update: May 16, 2012
Last modified: October 7, 2020
This is version 57 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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