UniProtKB - H9GBY9 (H9GBY9_ANOCA)
Protein
Submitted name:
Uncharacterized protein
Gene
gabrb1
Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Functioni
GO - Molecular functioni
- chloride channel activity Source: UniProtKB-KW
- extracellular ligand-gated ion channel activity Source: InterPro
- GABA-A receptor activity Source: InterPro
- neurotransmitter receptor activity Source: GO_Central
GO - Biological processi
- chemical synaptic transmission Source: GO_Central
- chloride transmembrane transport Source: GO_Central
- ion transmembrane transport Source: GO_Central
- nervous system process Source: GO_Central
- regulation of membrane potential Source: GO_Central
- signal transduction Source: GO_Central
Keywordsi
Molecular function | Chloride channelARBA annotation, Ion channel |
Biological process | Ion transport, Transport |
Ligand | Chloride |
Names & Taxonomyi
Protein namesi | Submitted name: Uncharacterized proteinImported |
Gene namesi | Name:gabrb1Imported |
Organismi | Anolis carolinensis (Green anole) (American chameleon)Imported |
Taxonomic identifieri | 28377 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Iguania › Dactyloidae › Anolis |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- postsynaptic cell membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
- Cell membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- postsynaptic membrane Source: UniProtKB-SubCell
Other locations
- chloride channel complex Source: UniProtKB-KW
- GABA-A receptor complex Source: GO_Central
- neuron projection Source: GO_Central
- synapse Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 216 – 240 | HelicalUniRule annotationAdd BLAST | 25 | |
Transmembranei | 246 – 266 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 278 – 300 | HelicalUniRule annotationAdd BLAST | 23 | |
Transmembranei | 428 – 446 | HelicalUniRule annotationAdd BLAST | 19 |
Keywords - Cellular componenti
Cell junction, Cell membraneARBA annotation, Membrane, Postsynaptic cell membraneARBA annotation, SynapseExpressioni
Gene expression databases
Bgeei | ENSACAG00000006768, Expressed in testis and 7 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 12 – 215 | Neur_chan_LBDInterPro annotationAdd BLAST | 204 | |
Domaini | 223 – 442 | Neur_chan_membInterPro annotationAdd BLAST | 220 |
Sequence similaritiesi
Keywords - Domaini
SignalARBA annotation, Transmembrane, Transmembrane helixUniRule annotationARBA annotationPhylogenomic databases
eggNOGi | KOG3643, Eukaryota |
GeneTreei | ENSGT00940000154713 |
HOGENOMi | CLU_010920_0_1_1 |
InParanoidi | H9GBY9 |
OrthoDBi | 480926at2759 |
TreeFami | TF315453 |
Family and domain databases
Gene3Di | 2.70.170.10, 1 hit |
InterProi | View protein in InterPro IPR006028, GABAA/Glycine_rcpt IPR002289, GABAAb_rcpt IPR006202, Neur_chan_lig-bd IPR036734, Neur_chan_lig-bd_sf IPR006201, Neur_channel IPR036719, Neuro-gated_channel_TM_sf IPR006029, Neurotrans-gated_channel_TM IPR018000, Neurotransmitter_ion_chnl_CS |
PANTHERi | PTHR18945, PTHR18945, 1 hit |
Pfami | View protein in Pfam PF02931, Neur_chan_LBD, 1 hit PF02932, Neur_chan_memb, 1 hit |
PRINTSi | PR01160, GABAARBETA PR00253, GABAARECEPTR PR00252, NRIONCHANNEL |
SUPFAMi | SSF63712, SSF63712, 1 hit SSF90112, SSF90112, 1 hit |
TIGRFAMsi | TIGR00860, LIC, 1 hit |
PROSITEi | View protein in PROSITE PS00236, NEUROTR_ION_CHANNEL, 1 hit |
i Sequence
Sequence statusi: Complete.
H9GBY9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNEPSNMSYV KETVDRLLKG YDIRLRPDFG GSPVDVGMRI EIASIDMVSE
60 70 80 90 100
VNMDYTLTMY FQQSWRDKRL SYSGIPLNLT LDNRVADNLW VPDTYFLNDK
110 120 130 140 150
KSFVHGVTVK NRMIRLHPDG TVLYGLRITT TAACMMDLRR YPLDEQNCTL
160 170 180 190 200
EIESYGYTTD DIEFYWNGGE SAVSGVSKIE LPQFSIMDYR MISKRVEFAT
210 220 230 240 250
GAYPRLSLSF RLKRNIGYFI LQTYMPSTLI TILSWVSFWI NYDASAARVA
260 270 280 290 300
LGITTVLTMT TISTHLRETL PKIPYVKAID IYLMGCFVFV FLALLEYAFV
310 320 330 340 350
NYTFFGKGPQ HQKKAAEKAT TEKKKLEMNK VQIDACGNIL LTTLEMRNEV
360 370 380 390 400
SGSNVLGSLN DPRGTMYSYD SASIHYRRPP PTRDLYSRSP LDRHTVHQKG
410 420 430 440
RLRRRASQLK VKIPDLTDVN SIDKWSRMVF PITFILFNVV YWLYYVH
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAWZ02023653 Genomic DNA No translation available. AAWZ02023654 Genomic DNA No translation available. AAWZ02023655 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENSACAT00000006827; ENSACAP00000006681; ENSACAG00000006768 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAWZ02023653 Genomic DNA No translation available. AAWZ02023654 Genomic DNA No translation available. AAWZ02023655 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000006681 |
Genome annotation databases
Ensembli | ENSACAT00000006827; ENSACAP00000006681; ENSACAG00000006768 |
Phylogenomic databases
eggNOGi | KOG3643, Eukaryota |
GeneTreei | ENSGT00940000154713 |
HOGENOMi | CLU_010920_0_1_1 |
InParanoidi | H9GBY9 |
OrthoDBi | 480926at2759 |
TreeFami | TF315453 |
Gene expression databases
Bgeei | ENSACAG00000006768, Expressed in testis and 7 other tissues |
Family and domain databases
Gene3Di | 2.70.170.10, 1 hit |
InterProi | View protein in InterPro IPR006028, GABAA/Glycine_rcpt IPR002289, GABAAb_rcpt IPR006202, Neur_chan_lig-bd IPR036734, Neur_chan_lig-bd_sf IPR006201, Neur_channel IPR036719, Neuro-gated_channel_TM_sf IPR006029, Neurotrans-gated_channel_TM IPR018000, Neurotransmitter_ion_chnl_CS |
PANTHERi | PTHR18945, PTHR18945, 1 hit |
Pfami | View protein in Pfam PF02931, Neur_chan_LBD, 1 hit PF02932, Neur_chan_memb, 1 hit |
PRINTSi | PR01160, GABAARBETA PR00253, GABAARECEPTR PR00252, NRIONCHANNEL |
SUPFAMi | SSF63712, SSF63712, 1 hit SSF90112, SSF90112, 1 hit |
TIGRFAMsi | TIGR00860, LIC, 1 hit |
PROSITEi | View protein in PROSITE PS00236, NEUROTR_ION_CHANNEL, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | H9GBY9_ANOCA | |
Accessioni | H9GBY9Primary (citable) accession number: H9GBY9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 16, 2012 |
Last sequence update: | June 26, 2013 | |
Last modified: | April 7, 2021 | |
This is version 59 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |