UniProtKB - H9GBY1 (H9GBY1_ANOCA)
Protein
Procollagen-lysine 5-dioxygenase
Gene
PLOD2
Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Functioni
Catalytic activityi
- 2-oxoglutarate + L-lysyl-[procollagen] + O2 = (5R)-5-hydroxy-L-lysyl-[procollagen] + CO2 + succinateARBA annotationEC:1.14.11.4ARBA annotation
Cofactori
Protein has several cofactor binding sites:- Fe2+ARBA annotation
- L-ascorbateARBA annotation
GO - Molecular functioni
- iron ion binding Source: InterPro
- L-ascorbic acid binding Source: UniProtKB-KW
- procollagen-lysine 5-dioxygenase activity Source: GO_Central
GO - Biological processi
- hydroxylysine biosynthetic process Source: Ensembl
- peptidyl-lysine hydroxylation Source: GO_Central
- response to hypoxia Source: Ensembl
Keywordsi
Molecular function | DioxygenaseARBA annotation, Oxidoreductase |
Ligand | IronARBA annotation, Metal-bindingARBA annotation, Vitamin CARBA annotation |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:PLOD2Imported |
Organismi | Anolis carolinensis (Green anole) (American chameleon)Imported |
Taxonomic identifieri | 28377 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Iguania › Dactyloidae › Anolis |
Proteomesi |
|
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane ARBA annotation; Peripheral membrane protein ARBA annotation; Lumenal side ARBA annotation
Endoplasmic reticulum
- endoplasmic reticulum Source: GO_Central
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
MembraneARBA annotationPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 28 | Sequence analysisAdd BLAST | 28 | |
ChainiPRO_5003621054 | 29 – 759 | Procollagen-lysine 5-dioxygenaseSequence analysisAdd BLAST | 731 |
Expressioni
Gene expression databases
Bgeei | ENSACAG00000006657, Expressed in heart and 14 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 666 – 759 | Fe2OG dioxygenaseInterPro annotationAdd BLAST | 94 |
Keywords - Domaini
SignalSequence analysisARBA annotationPhylogenomic databases
eggNOGi | KOG1971, Eukaryota |
GeneTreei | ENSGT00990000203644 |
HOGENOMi | CLU_022320_1_0_1 |
InParanoidi | H9GBY1 |
OrthoDBi | 194164at2759 |
TreeFami | TF313826 |
Family and domain databases
Gene3Di | 3.90.550.10, 1 hit |
InterProi | View protein in InterPro IPR029044, Nucleotide-diphossugar_trans IPR005123, Oxoglu/Fe-dep_dioxygenase IPR006620, Pro_4_hyd_alph IPR001006, Procol_lys_dOase |
Pfami | View protein in Pfam PF03171, 2OG-FeII_Oxy, 1 hit |
SMARTi | View protein in SMART SM00702, P4Hc, 1 hit |
SUPFAMi | SSF53448, SSF53448, 1 hit |
PROSITEi | View protein in PROSITE PS51471, FE2OG_OXY, 1 hit PS01325, LYS_HYDROXYLASE, 1 hit |
i Sequence
Sequence statusi: Complete.
H9GBY1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MARNLSGPLA LALAFVVHLL QLIHPAEPTP ERPPIPTDKL LVLTIATKET
60 70 80 90 100
DGFHRFMQSA KHFNYTVKIL GEGEKWKGGK SLNSIGGGQK VRLLKSALDI
110 120 130 140 150
YADQEDLVVM YVDCYDVIFA AGPEELLKKF QQANHKVVFA ADGLIWPDKR
160 170 180 190 200
LSDKYPVVRS GKRFLNAGGF IGYSPSVNSI VQQWDLQDND DDQLFYTKIY
210 220 230 240 250
IDPLKRERIN ITLDHKCNIF QTLNGAVDEV LLKFEEGRAR ARNSVYDTLP
260 270 280 290 300
VTLHGNGPTK LNLNYFGNYI PNGWTRETGC IACNKDLLDL ATLTETPTVI
310 320 330 340 350
IGVFIEQPTP FLARFLDRLL TLDYAKEKLS FFIHNNEVYH EKHIKKFWEK
360 370 380 390 400
AKNMIKTIKI VGPEENLSQA DARNMGMEIC RQNKECDYYF SIDADVVLTN
410 420 430 440 450
PDTLKILIEQ NRKIIAPLVM RHGKLWSNFW GALSADGYYA RSEDYIDIVQ
460 470 480 490 500
GNRVGLWNVP FVANIYLIKG QTLRSEMKER NYFARERLDS DMALCRNARE
510 520 530 540 550
MTLQREKDSP SAETFHMLRP PKGVFMYITN RHEFGRLLST ANYNISHYNN
560 570 580 590 600
DLWQIFENPV DWKEVYINPN YSKIFTEKIV EQPCPDVFWF PIFSEAACDE
610 620 630 640 650
LVEEMEHFGQ WSGGRHHDSR ISGGYENVPT DDIHMKQIGL ENVWLHFIRE
660 670 680 690 700
FIAPVTLKVF AGYYTKGHAL LNFVVKYSPD RQRSLRPHHD ASTFTINIAL
710 720 730 740 750
NKVEEDFQGG GCKFLRYNCS IESPRKGWSF MHPGRLTHLH EGLPILKGTR
YIAVSFIDP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAWZ02027841 Genomic DNA No translation available. |
RefSeqi | XP_003227039.1, XM_003226991.3 |
Genome annotation databases
Ensembli | ENSACAT00000006807; ENSACAP00000006661; ENSACAG00000006657 |
GeneIDi | 100558233 |
KEGGi | acs:100558233 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAWZ02027841 Genomic DNA No translation available. |
RefSeqi | XP_003227039.1, XM_003226991.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000006661 |
Genome annotation databases
Ensembli | ENSACAT00000006807; ENSACAP00000006661; ENSACAG00000006657 |
GeneIDi | 100558233 |
KEGGi | acs:100558233 |
Organism-specific databases
CTDi | 5352 |
Phylogenomic databases
eggNOGi | KOG1971, Eukaryota |
GeneTreei | ENSGT00990000203644 |
HOGENOMi | CLU_022320_1_0_1 |
InParanoidi | H9GBY1 |
OrthoDBi | 194164at2759 |
TreeFami | TF313826 |
Gene expression databases
Bgeei | ENSACAG00000006657, Expressed in heart and 14 other tissues |
Family and domain databases
Gene3Di | 3.90.550.10, 1 hit |
InterProi | View protein in InterPro IPR029044, Nucleotide-diphossugar_trans IPR005123, Oxoglu/Fe-dep_dioxygenase IPR006620, Pro_4_hyd_alph IPR001006, Procol_lys_dOase |
Pfami | View protein in Pfam PF03171, 2OG-FeII_Oxy, 1 hit |
SMARTi | View protein in SMART SM00702, P4Hc, 1 hit |
SUPFAMi | SSF53448, SSF53448, 1 hit |
PROSITEi | View protein in PROSITE PS51471, FE2OG_OXY, 1 hit PS01325, LYS_HYDROXYLASE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | H9GBY1_ANOCA | |
Accessioni | H9GBY1Primary (citable) accession number: H9GBY1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 16, 2012 |
Last sequence update: | June 26, 2013 | |
Last modified: | December 2, 2020 | |
This is version 51 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |