UniProtKB - H9GBQ2 (H9GBQ2_ANOCA)
Protein
RING-type domain-containing protein
Gene
RFWD3
Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Functioni
GO - Molecular functioni
- MDM2/MDM4 family protein binding Source: Ensembl
- metal ion binding Source: UniProtKB-KW
- p53 binding Source: Ensembl
- ubiquitin protein ligase activity Source: Ensembl
GO - Biological processi
- chromosome breakage Source: Ensembl
- double-strand break repair via homologous recombination Source: Ensembl
- interstrand cross-link repair Source: Ensembl
- mitotic G1 DNA damage checkpoint Source: Ensembl
- regulation of DNA damage checkpoint Source: Ensembl
- replication fork processing Source: Ensembl
- response to ionizing radiation Source: Ensembl
Keywordsi
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: RING-type domain-containing proteinInterPro annotation |
Gene namesi | Name:RFWD3Imported |
Organismi | Anolis carolinensis (Green anole) (American chameleon)Imported |
Taxonomic identifieri | 28377 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Iguania › Dactyloidae › Anolis |
Proteomesi |
|
Subcellular locationi
Nucleus
- nucleoplasm Source: Ensembl
Other locations
- site of double-strand break Source: Ensembl
Expressioni
Gene expression databases
Bgeei | ENSACAG00000006627, Expressed in female gonad and 13 other tissues |
Interactioni
GO - Molecular functioni
- MDM2/MDM4 family protein binding Source: Ensembl
- p53 binding Source: Ensembl
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000006486 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 213 – 257 | RING-typeInterPro annotationAdd BLAST | 45 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 145 | DisorderedSequence analysisAdd BLAST | 145 | |
Regioni | 158 – 206 | DisorderedSequence analysisAdd BLAST | 49 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 290 – 329 | Sequence analysisAdd BLAST | 40 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 89 – 134 | PolarSequence analysisAdd BLAST | 46 | |
Compositional biasi | 181 – 195 | PolarSequence analysisAdd BLAST | 15 |
Keywords - Domaini
Coiled coilSequence analysis, Zinc-fingerPROSITE-ProRule annotationARBA annotationPhylogenomic databases
eggNOGi | KOG1645, Eukaryota |
GeneTreei | ENSGT00390000008931 |
HOGENOMi | CLU_021009_1_0_1 |
InParanoidi | H9GBQ2 |
OrthoDBi | 1451258at2759 |
TreeFami | TF323359 |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR037381, RFWD3 IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR036322, WD40_repeat_dom_sf IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD |
PANTHERi | PTHR16047, PTHR16047, 1 hit |
Pfami | View protein in Pfam PF13639, zf-RING_2, 1 hit |
SMARTi | View protein in SMART SM00184, RING, 1 hit SM00320, WD40, 2 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS50089, ZF_RING_2, 1 hit |
i Sequence
Sequence statusi: Complete.
H9GBQ2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAQEAMEVDL LPAAEEAGRP SGEGRGASGS GAGPGPLAGP GPASPRPSWA
60 70 80 90 100
AFSGEAEPRR PPPPPRARGN RARRAPRAAP GRATAPLESY FQVSRTQATD
110 120 130 140 150
PSDVLAVLNR NSSDEPVVLS DAESSRSSSS SSSTEVEEDD NEPERALDVA
160 170 180 190 200
LGPAVLRASG SSQAEPPGDG PSEPEGNPDP GGSSPATQKT SPLKNPSLAA
210 220 230 240 250
PPLPLEEESG DTCAICFEEW TNAGEHRLSA LRCGHLFGYS CIQRWLKGQA
260 270 280 290 300
GKCPQCNKKA KRSDIVVLYA RTLKALDTSE QEHMKSSLEK EQMLRRKAEL
310 320 330 340 350
ESAQSRLQLQ VLTDECSKLR QQVQELKTLM ARHSTPSSQQ PGHSRSCFPG
360 370 380 390 400
CLSSSQGQHK YHFERAFLVS QVGNCRVMAY CDPLSCLVIS QPSPQSTFIP
410 420 430 440 450
GCGIKMMSAV NLKSSQYVPI HNKQIRGLAF SNRADGLLLS AALDHTLKLT
460 470 480 490 500
SLTTNTVVQT YNAGRPIWSC CWCLDDTNYI YAGLVNGSVL VYDLRDTRSQ
510 520 530 540 550
VQELAPQKSR CPVVSLSYLP RMASASLPYG GLVSGTLEGA CFWEQKGSGT
560 570 580 590 600
YKPHHLLLEP GGCVDLQTEA NTRHCLATFR PNRNHNSLRC VVMELTSTQL
610 620 630 640 650
TDGAEDAVCS CRPVQTLTAG PTCKLLTKNA IFQSPEDNGS ILVCAGDEAS
660 670 680 690 700
NSAMLWDAGS GTLLQKLTAD LPVLDVCPYE VNRSSFLAIL TEKMVKIYKW
Q
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAWZ02033309 Genomic DNA No translation available. AAWZ02033310 Genomic DNA No translation available. |
RefSeqi | XP_008121395.1, XM_008123188.2 |
Genome annotation databases
Ensembli | ENSACAT00000006631; ENSACAP00000006486; ENSACAG00000006627 |
GeneIDi | 100565467 |
KEGGi | acs:100565467 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAWZ02033309 Genomic DNA No translation available. AAWZ02033310 Genomic DNA No translation available. |
RefSeqi | XP_008121395.1, XM_008123188.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000006486 |
Genome annotation databases
Ensembli | ENSACAT00000006631; ENSACAP00000006486; ENSACAG00000006627 |
GeneIDi | 100565467 |
KEGGi | acs:100565467 |
Organism-specific databases
CTDi | 55159 |
Phylogenomic databases
eggNOGi | KOG1645, Eukaryota |
GeneTreei | ENSGT00390000008931 |
HOGENOMi | CLU_021009_1_0_1 |
InParanoidi | H9GBQ2 |
OrthoDBi | 1451258at2759 |
TreeFami | TF323359 |
Gene expression databases
Bgeei | ENSACAG00000006627, Expressed in female gonad and 13 other tissues |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR037381, RFWD3 IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR036322, WD40_repeat_dom_sf IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD |
PANTHERi | PTHR16047, PTHR16047, 1 hit |
Pfami | View protein in Pfam PF13639, zf-RING_2, 1 hit |
SMARTi | View protein in SMART SM00184, RING, 1 hit SM00320, WD40, 2 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS50089, ZF_RING_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | H9GBQ2_ANOCA | |
Accessioni | H9GBQ2Primary (citable) accession number: H9GBQ2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 16, 2012 |
Last sequence update: | June 26, 2013 | |
Last modified: | December 2, 2020 | |
This is version 53 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |