UniProtKB - H9GBC0 (H9GBC0_ANOCA)
Protein
Alpha-1A adrenergic receptor
Gene
ADRA1A
Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Functioni
GO - Molecular functioni
- alpha1-adrenergic receptor activity Source: GO_Central
- G protein-coupled receptor activity Source: GO_Central
- protein heterodimerization activity Source: Ensembl
GO - Biological processi
- adenylate cyclase-activating adrenergic receptor signaling pathway Source: GO_Central
- adult heart development Source: Ensembl
- cell-cell signaling Source: GO_Central
- cell growth involved in cardiac muscle cell development Source: Ensembl
- negative regulation of autophagy Source: Ensembl
- negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure Source: Ensembl
- neuron-glial cell signaling Source: Ensembl
- norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure Source: Ensembl
- phospholipase C-activating G protein-coupled receptor signaling pathway Source: GO_Central
- positive regulation of cardiac muscle hypertrophy Source: Ensembl
- positive regulation of cytosolic calcium ion concentration Source: GO_Central
- positive regulation of heart rate by epinephrine-norepinephrine Source: GO_Central
- positive regulation of MAPK cascade Source: GO_Central
- positive regulation of non-membrane spanning protein tyrosine kinase activity Source: Ensembl
- positive regulation of smooth muscle contraction Source: Ensembl
- positive regulation of the force of heart contraction by epinephrine-norepinephrine Source: Ensembl
- positive regulation of vasoconstriction Source: GO_Central
- regulation of cardiac muscle contraction Source: InterPro
Keywordsi
Molecular function | G-protein coupled receptorUniRule annotationARBA annotation, Receptor, Transducer |
Names & Taxonomyi
Protein namesi | Recommended name: Alpha-1A adrenergic receptorARBA annotationAlternative name(s): Alpha-1A adrenoreceptorARBA annotation Alpha-1C adrenergic receptorARBA annotation |
Gene namesi | Name:ADRA1AImported |
Organismi | Anolis carolinensis (Green anole) (American chameleon)Imported |
Taxonomic identifieri | 28377 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Iguania › Dactyloidae › Anolis |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Nucleus
- Nucleus membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Other locations
- Cytoplasm ARBA annotation
- caveola ARBA annotation
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Nucleus
- nuclear membrane Source: UniProtKB-SubCell
Plasma Membrane
- caveola Source: UniProtKB-SubCell
- integral component of plasma membrane Source: GO_Central
Other locations
- cytoplasm Source: UniProtKB-SubCell
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 28 – 54 | HelicalSequence analysisAdd BLAST | 27 | |
Transmembranei | 66 – 96 | HelicalSequence analysisAdd BLAST | 31 | |
Transmembranei | 102 – 124 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 145 – 166 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 186 – 211 | HelicalSequence analysisAdd BLAST | 26 | |
Transmembranei | 276 – 300 | HelicalSequence analysisAdd BLAST | 25 | |
Transmembranei | 312 – 330 | HelicalSequence analysisAdd BLAST | 19 |
Keywords - Cellular componenti
Cell membraneARBA annotation, CytoplasmARBA annotation, Membrane, NucleusARBA annotationExpressioni
Gene expression databases
Bgeei | ENSACAG00000006376, Expressed in liver and 7 other tissues |
Interactioni
GO - Molecular functioni
- protein heterodimerization activity Source: Ensembl
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000006243 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 45 – 328 | G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST | 284 |
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.UniRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00940000159105 |
HOGENOMi | CLU_009579_11_6_1 |
InParanoidi | H9GBC0 |
OrthoDBi | 1095345at2759 |
TreeFami | TF331895 |
Family and domain databases
InterProi | View protein in InterPro IPR002233, ADR_fam IPR001004, ADRA1A_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR01103, ADRENERGICR PR00557, ADRENRGCA1AR PR00237, GPCRRHODOPSN |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
H9GBC0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSLNVENISV PACVNCTQTV EEVNVLKAIL LGVIFGGLII FGVLGNILVI
60 70 80 90 100
LSVACHKHLQ SVTHYYIINL AVADLLLTST VLPFSAIFEI FGYWIFGRIF
110 120 130 140 150
CNIWAAVDVL CCTASIMSLC VISIDRYIGV SYPLRYPSIV TEKRGLLALL
160 170 180 190 200
CIWVLSLVIS IGPLFGWKQP APEDEKICQI NTDPGYVLFS AFGSFYLPLI
210 220 230 240 250
IILVMYCRVY VVARRESKGL SCGLKTEKSH SEEVTLRIHC KNATETTGST
260 270 280 290 300
PSTKHKSHFS MRLLKFSREK KAAKSLGIVV GCFILCWLPF FLIMPIGSFF
310 320 330 340 350
PESKPSDTVF KIAFWLGYLN SCINPIIYPC SSQEFKKAFQ NVLRGQCLPR
360 370 380 390 400
RYSANKYSLS FNHHHPSNHV AETPKDVVCI PVNSGENFYK ISKSDGICEW
410 420 430 440 450
KLFSTVQSMS TKSASSKDKA KVKSKGFLRV CCCADTSGSD HPKGQKVPTI
460
KIHTISISDN GEDV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAWZ02028091 Genomic DNA No translation available. |
RefSeqi | XP_003227101.1, XM_003227053.3 |
Genome annotation databases
Ensembli | ENSACAT00000006382; ENSACAP00000006243; ENSACAG00000006376 |
GeneIDi | 100554316 |
KEGGi | acs:100554316 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAWZ02028091 Genomic DNA No translation available. |
RefSeqi | XP_003227101.1, XM_003227053.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000006243 |
Protein family/group databases
GPCRDBi | Search... |
Genome annotation databases
Ensembli | ENSACAT00000006382; ENSACAP00000006243; ENSACAG00000006376 |
GeneIDi | 100554316 |
KEGGi | acs:100554316 |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00940000159105 |
HOGENOMi | CLU_009579_11_6_1 |
InParanoidi | H9GBC0 |
OrthoDBi | 1095345at2759 |
TreeFami | TF331895 |
Gene expression databases
Bgeei | ENSACAG00000006376, Expressed in liver and 7 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR002233, ADR_fam IPR001004, ADRA1A_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR01103, ADRENERGICR PR00557, ADRENRGCA1AR PR00237, GPCRRHODOPSN |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | H9GBC0_ANOCA | |
Accessioni | H9GBC0Primary (citable) accession number: H9GBC0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 16, 2012 |
Last sequence update: | June 26, 2013 | |
Last modified: | December 2, 2020 | |
This is version 55 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |