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Entry version 59 (02 Dec 2020)
Sequence version 2 (26 Jun 2013)
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Protein
Submitted name:

Uncharacterized protein

Gene

syne1

Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-bindingARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:syne1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnolis carolinensis (Green anole) (American chameleon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri28377 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaIguaniaDactyloidaeAnolis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001646 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 8754CytoplasmicPROSITE-ProRule annotationAdd BLAST8754
Topological domaini8776 – 8805Perinuclear spacePROSITE-ProRule annotationAdd BLAST30

Keywords - Cellular componenti

Membrane, NucleusARBA annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSACAG00000005645, Expressed in testis and 14 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
28377.ENSACAP00000006053

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini43 – 150Calponin-homology (CH)InterPro annotationAdd BLAST108
Domaini194 – 299Calponin-homology (CH)InterPro annotationAdd BLAST106
Domaini8746 – 8805KASHInterPro annotationAdd BLAST60

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni5864 – 5891DisorderedSequence analysisAdd BLAST28
Regioni5913 – 5941DisorderedSequence analysisAdd BLAST29
Regioni6220 – 6242DisorderedSequence analysisAdd BLAST23
Regioni8248 – 8282DisorderedSequence analysisAdd BLAST35
Regioni8681 – 8739DisorderedSequence analysisAdd BLAST59

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili621 – 648Sequence analysisAdd BLAST28
Coiled coili816 – 836Sequence analysisAdd BLAST21
Coiled coili924 – 944Sequence analysisAdd BLAST21
Coiled coili1237 – 1264Sequence analysisAdd BLAST28
Coiled coili1315 – 1342Sequence analysisAdd BLAST28
Coiled coili1407 – 1434Sequence analysisAdd BLAST28
Coiled coili1463 – 1483Sequence analysisAdd BLAST21
Coiled coili1555 – 1582Sequence analysisAdd BLAST28
Coiled coili1641 – 1661Sequence analysisAdd BLAST21
Coiled coili1903 – 1923Sequence analysisAdd BLAST21
Coiled coili1985 – 2008Sequence analysisAdd BLAST24
Coiled coili2129 – 2149Sequence analysisAdd BLAST21
Coiled coili2238 – 2265Sequence analysisAdd BLAST28
Coiled coili3162 – 3182Sequence analysisAdd BLAST21
Coiled coili3210 – 3244Sequence analysisAdd BLAST35
Coiled coili3406 – 3426Sequence analysisAdd BLAST21
Coiled coili3467 – 3487Sequence analysisAdd BLAST21
Coiled coili3519 – 3542Sequence analysisAdd BLAST24
Coiled coili3691 – 3711Sequence analysisAdd BLAST21
Coiled coili3915 – 3935Sequence analysisAdd BLAST21
Coiled coili3967 – 3987Sequence analysisAdd BLAST21
Coiled coili4176 – 4196Sequence analysisAdd BLAST21
Coiled coili4282 – 4302Sequence analysisAdd BLAST21
Coiled coili4344 – 4364Sequence analysisAdd BLAST21
Coiled coili4523 – 4550Sequence analysisAdd BLAST28
Coiled coili4674 – 4694Sequence analysisAdd BLAST21
Coiled coili4753 – 4808Sequence analysisAdd BLAST56
Coiled coili4826 – 4846Sequence analysisAdd BLAST21
Coiled coili4918 – 4938Sequence analysisAdd BLAST21
Coiled coili4964 – 4984Sequence analysisAdd BLAST21
Coiled coili5069 – 5096Sequence analysisAdd BLAST28
Coiled coili5214 – 5241Sequence analysisAdd BLAST28
Coiled coili5362 – 5382Sequence analysisAdd BLAST21
Coiled coili5609 – 5657Sequence analysisAdd BLAST49
Coiled coili5736 – 5763Sequence analysisAdd BLAST28
Coiled coili5774 – 5811Sequence analysisAdd BLAST38
Coiled coili6007 – 6027Sequence analysisAdd BLAST21
Coiled coili6062 – 6089Sequence analysisAdd BLAST28
Coiled coili6306 – 6326Sequence analysisAdd BLAST21
Coiled coili6529 – 6556Sequence analysisAdd BLAST28
Coiled coili6584 – 6611Sequence analysisAdd BLAST28
Coiled coili6694 – 6714Sequence analysisAdd BLAST21
Coiled coili7060 – 7087Sequence analysisAdd BLAST28
Coiled coili7166 – 7196Sequence analysisAdd BLAST31
Coiled coili7600 – 7620Sequence analysisAdd BLAST21
Coiled coili7650 – 7670Sequence analysisAdd BLAST21
Coiled coili7717 – 7737Sequence analysisAdd BLAST21
Coiled coili7815 – 7859Sequence analysisAdd BLAST45
Coiled coili7922 – 7942Sequence analysisAdd BLAST21
Coiled coili8471 – 8491Sequence analysisAdd BLAST21
Coiled coili8513 – 8533Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi5866 – 5891PolarSequence analysisAdd BLAST26
Compositional biasi6220 – 6236PolarSequence analysisAdd BLAST17
Compositional biasi8251 – 8270PolarSequence analysisAdd BLAST20

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the nesprin family.ARBA annotation

Keywords - Domaini

Coiled coilSequence analysisARBA annotation, RepeatARBA annotation, Transmembrane, Transmembrane helixARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0516, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154481

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000025_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
H9GB25

TreeFam database of animal gene trees

More...
TreeFami
TF329280

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00014, CH, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.418.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001589, Actinin_actin-bd_CS
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR012315, KASH
IPR018159, Spectrin/alpha-actinin
IPR002017, Spectrin_repeat
IPR030265, SYNE1

The PANTHER Classification System

More...
PANTHERi
PTHR14514:SF3, PTHR14514:SF3, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00307, CH, 2 hits
PF10541, KASH, 1 hit
PF00435, Spectrin, 9 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00033, CH, 2 hits
SM01249, KASH, 1 hit
SM00150, SPEC, 37 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47576, SSF47576, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00019, ACTININ_1, 1 hit
PS00020, ACTININ_2, 1 hit
PS50021, CH, 2 hits
PS51049, KASH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

H9GB25-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCVLAPAPAF AFSFTFGSLF FGRRGRRSLC ILKYLQRLYE QESVQKRTFT
60 70 80 90 100
KWINTHLAKR KPPMVVNDLF EDIKDGVILI ALLEVLSGQK LPCEQGRKLK
110 120 130 140 150
RIHGVANIGT ALKFLEGRRI KLVNINSTDI ADGRPSIVLG LVWTIILYFQ
160 170 180 190 200
IEELTSNLPQ LQSLSSSTSS VDSVVSSETA SPPSKRKVVT KVQGNAKKAL
210 220 230 240 250
LKWVQYTAAK QAGIEVKDFG RSWRSGVAFH SVIHAIRPEL VDLERVKTRS
260 270 280 290 300
NRENLEEAFT IAECELGIPR LLDPEDVDVD KPDEKSVMTY VAQFLKHYPD
310 320 330 340 350
LHNTPNDAQE ADKEDRLMLR DLKVWVEQFE RDLIRTQIME TSLQEKYQSF
360 370 380 390 400
KYYRIQYEVK RKQIELGIQS LRKDGKLSLD QALVKQAWDR ITSRLFEWHL
410 420 430 440 450
HLDKSLPAPL GTIGAWLYRA ETSLRDEIII QQAHEETANV IHRKLEQHKD
460 470 480 490 500
VLKNIDGFKK TFQEIHRAQS VNGVPVPTEQ LDDMAERFNF VASTAELHLL
510 520 530 540 550
KMEFLELKYR LLSLLVFAES KLKSWIIKYG RRESVELLLQ NYMSVIENNK
560 570 580 590 600
FFEQYEVTYQ ILKKAADMYA KANGSPEEIE SVARFMSDTT TQWRHLSVEV
610 620 630 640 650
RSVKSMLEEV ISNWDRYSST VASLQAWLED AEKMLNQAEH AKKDFFRHLP
660 670 680 690 700
QWIQQHTTMN DAGNFLIETC DETISRDLKQ QLLLLNGRWR ELFMQVKQYA
710 720 730 740 750
RADEFDKTRK EYSDGVTMLS TFIDEARRKI RIPLEVSFLN VKMFVQEMED
760 770 780 790 800
IKQKVPVMES QYKMVTRTAQ LVTKEIPQEE INEMLATMSG IKGQLNKINE
810 820 830 840 850
SCPVVLYESQ QLLPHLEELE KQITHFYESL EKINEIVSIL DPEAQPADVF
860 870 880 890 900
KQQHQDLVAY QENCKKAFSL IERNSQSITK LVSSSKVLQH FSLSVLQKKV
910 920 930 940 950
IEIQAAFQNM VKKTGDWKKS VQANNRLMKK FEESRTELEN VLQMAHCHLK
960 970 980 990 1000
ERGNPEELLR KHTEFFSQLD QRVLNAFLKA CDELTDILPE QEQHSLQEAV
1010 1020 1030 1040 1050
RKLHKQWKDL QSEAPYHLLR LKIELEKNKF LASMQECHAE LARQQDLMSK
1060 1070 1080 1090 1100
ESSEKIIREH KLFFGDKGPL QQCEKRLHLI KELCLKLPEW DPLKKTSENS
1110 1120 1130 1140 1150
QLGLSELKSH VANIYAKLMD HPDKWKVYKN RFSELESWIS SRESHLKKIK
1160 1170 1180 1190 1200
HEATDTAKYK HSKTSIEEIR QEACKKGETL IWLKSRLAAL SEVSSEDETK
1210 1220 1230 1240 1250
KQEDALSKLS NDFKSILTSL TEIEKTLGTV GDCVQYAEEV KGHLEELITN
1260 1270 1280 1290 1300
SKEAQEEVER ILDVESLLQA QQLLRYHQQK TKRLHIKRQD MQQQMARGKQ
1310 1320 1330 1340 1350
LQMEGGLSPT GQDDLWKLEN TLENVQQSMD KQEDQLKITV NTWEQFERDK
1360 1370 1380 1390 1400
EIIVKYLSHA SSALERILSF SSLESLSSEL EKTKELSKQT VAMAIEAENL
1410 1420 1430 1440 1450
VKKSFAIQLG EKSKQNLQQQ AKSVQDQLEK VEATTEEDIK TMERVKNKWN
1460 1470 1480 1490 1500
HFGKSFEALS TWITEKEKEL DALEASSSSL ELQINQIKVM IKEIDAKDDE
1510 1520 1530 1540 1550
IPNLEEAAQS FSQYLTSGES AHIKAKLTQI RRYWEELRDH TQHLEGAIKG
1560 1570 1580 1590 1600
KATVQQKFEE NFTKFQEELS KYESELAELD TLCSSSAETY KVLQDLMDLS
1610 1620 1630 1640 1650
QVIEKMNQTL STLSSGSRKI TNKEKAIHDV LMLQQRHENV MRQAKDRQAS
1660 1670 1680 1690 1700
LETHLAQWQR LEKELSTFLT WLESCEAAAK PIEQYVSADR VKLESELQLV
1710 1720 1730 1740 1750
QDLQVDVTSH ASLYTSLLQL NESLIETNPN ESLKKFKKDL EELDRRWKIL
1760 1770 1780 1790 1800
PQTVSKRISF LHSVVAEHKQ YDELLLDFSE WIKQFLGKLH ATSEINTADQ
1810 1820 1830 1840 1850
QPALNHSKDH KKEVEGKYKE LQSLKSHVEK LCSFCRPEDH SVFQNKAEDC
1860 1870 1880 1890 1900
LQLYQEASQV IIRRQDVLPH LKAFLELHSA AVHMLQHLRQ TVETTGNINK
1910 1920 1930 1940 1950
SKSEVLEKEL SEVIQDVNKL ESSAASLDAS LTKAQYHLKH GSSEQRASCR
1960 1970 1980 1990 2000
NIADSVCIEL EAIQSLLGTK QSEAEALGVL HTSVMDRKEH LLKSIEDLEE
2010 2020 2030 2040 2050
RADKEGLQEP NLQEVQQRLR IFNQLDDELN SHQHELKWLM SKAKQIALKD
2060 2070 2080 2090 2100
ISLAPAIDKE INYLEAAWED TKKLIQERQE QCFILIDLMR NYQILKSTVT
2110 2120 2130 2140 2150
KAIEAASNVA VTKAMIKDQE DVKWALSKHE AARNELNDRQ SELDAFSNKG
2160 2170 2180 2190 2200
KHLLAELKKI PNCDSQLIKM DMDSTVDKWL DVSDKLEDSI EKLRVSVSLW
2210 2220 2230 2240 2250
EDVLRVGDDI DGWCSNSSSQ MNDILSNLTN CQQTESFLED FQSQIKHKEQ
2260 2270 2280 2290 2300
GLEQISSKIS ELKQLVNTEE LPMNLQFLEA DLRKKLMYAK EMCETAKDTV
2310 2320 2330 2340 2350
KDYNSQTLQL HNFVTQMEDW LTKMEESLLN CIHRQELSGL SRVKGIQKEL
2360 2370 2380 2390 2400
QQQQSQFDST QEILNGLCRK YPSVELETIG GTITSLMKKY ETVNQLSLKT
2410 2420 2430 2440 2450
QASMQESLEK HFQQSMCEFQ NWHSNLKTAV KGLSITSGDG KATEAKLCEL
2460 2470 2480 2490 2500
QKVLDSVNEG KSKLEAVSQE GEHLCTYLPK SSVTGIQEQI AKTHQDFEGL
2510 2520 2530 2540 2550
LKQCLKDKQA LEECVADLKS FEDLSKKWGL WLHEMEERMS TEALGESKQH
2560 2570 2580 2590 2600
IPEKKNEVKK VEAFLHEILL ARESFDKLTQ KAQILNEKGY SAGIETRLAS
2610 2620 2630 2640 2650
QHFSAYQNLI KSVKEKLKTS QMALQDHQAL EEAVQSMWSW LKDVQEKLAS
2660 2670 2680 2690 2700
AEGTTGNKAV LEKRLLQIQD ILLMKGEGEV KLNMAIGKGD QAIKGSNEEG
2710 2720 2730 2740 2750
QKEIENQLQT LKDLWNSIIS TSVSCQSLLD SVVNQWNDYL ERKSQLDQWL
2760 2770 2780 2790 2800
ESVDRKVEKP LDPQNDLKEK FSQLDYFQAV VSEMEDHSKD LHQLVGKARE
2810 2820 2830 2840 2850
LHEKTEDDSF REDVQEELKT QFSDITTVAK EKMRRIEDIV KDHLLYLDAV
2860 2870 2880 2890 2900
HEFTDWLHSA KEELHRWSDT SGDLTAIQKK LAKINELIDS RQTGESRLNR
2910 2920 2930 2940 2950
IQTLAPAVKQ NTTAQGCNDI DTEMQALQSD WKQWEESVFQ AQNSLQGLQN
2960 2970 2980 2990 3000
QMALSEHEFT TQAAHLEEAL QHFSMLLAAW SESLTPLDSK HTDKEIVEFW
3010 3020 3030 3040 3050
HREKETLDDL TKAEHMNDNI KTQLNDLCRF SKDLSTYSAK VSQLIKEYNS
3060 3070 3080 3090 3100
LCLQASKGCQ SKEQALQQRF RTVFRDFQQW LVNSKIMTAK CFDAPQSVSE
3110 3120 3130 3140 3150
ATANINKIQE FLSETESGQH KLNLAASKGE LLTSILPEEK AKSVQAKVAS
3160 3170 3180 3190 3200
AKEDWKKFIS MLHQKETTLE NLKVQMKDFE ASAEPLQAWL NETQKTVQES
3210 3220 3230 3240 3250
SNRLHDLPAK KREQQKLQSV LEEIRCHESQ LNRLKEKAQQ LWEEQAASKN
3260 3270 3280 3290 3300
FMHRVSQLSS QYLALSNITK EKVSRMDRIV AEHQHFSHDL KELQDWMSDA
3310 3320 3330 3340 3350
IQMLESYCHP TADKNALDSR MAKLEGLLSI KQEKEIQMKM LLTRGESVLQ
3360 3370 3380 3390 3400
NTSLEGVPVI EQQLRTLKDS WASLLSACIH CKSHLEGALS KWTNYQDDVR
3410 3420 3430 3440 3450
QFTSWMDKVE TIMNASERQH AELREKKSSL GKSKLLKEEV FSHSTLLETI
3460 3470 3480 3490 3500
EVKGMGMTEH YVTQLELQDI RERYQFLKDR IMGAIAKAEE MVHLHNEYQR
3510 3520 3530 3540 3550
NLKAFEIWLE KEQEKLNCLS HLEGDMERHE ATLRELQELQ VECADGQALL
3560 3570 3580 3590 3600
NAVLHIREQV IPWGVPQLED RILESVRQDW TVYQHKLSEV RTQLNTTLSK
3610 3620 3630 3640 3650
VRLMENKFLK VDEWLQTLEE KVNIRTGRQS DRATKEMQLQ QMKKWHEEIT
3660 3670 3680 3690 3700
VYKDEVEEVG LLAQQILEES NTCSATGRQA THLASRYQTL ILHVLEQIKF
3710 3720 3730 3740 3750
LEEEIRSMEE SELAFSAYKE WFGATHRKFS NVITKFEVVD KAAMEKKMQK
3760 3770 3780 3790 3800
LEELMSDMDI GHNLLKSSRE KGEKVMKYME GDEAEQLKKE IRGCMEQLDK
3810 3820 3830 3840 3850
MTFSIRKEHT TLEKCLHLTK EFLDKYKVQT QWLSECQSLL HTAVDPKMEL
3860 3870 3880 3890 3900
FEKKAQLSKY KSIQQTVLSH EPSIKSVFEK GECLLELVHD ANLAENIQKL
3910 3920 3930 3940 3950
QAEYQEVCTI AKTHVANLEV KVKQHEEYNN ELQEVEKWLL QMSSRLVTPD
3960 3970 3980 3990 4000
LMENSNLEII TQYLASHKAM MEEIAGFEDH LNSLKNKGDF LINDCAEHLQ
4010 4020 4030 4040 4050
AKFKQNVETQ LQGTRDSYSA ICSTAQRMYQ SLEKELQKHV SHQDTLQQCQ
4060 4070 4080 4090 4100
VWLSAVRPEL KPVPRPPFSL ADAVKQVKHF RALQEQASTY LDLLCSMCDL
4110 4120 4130 4140 4150
ADSTVKNIAT DIQLTKQTIE DRIMNSQYLA QGWEEVKQMK AELWIYFQDA
4160 4170 4180 4190 4200
DQQLQNMKRR GAELEPNIAQ NMVLQVKEFS QKLQSKQTAL TALTEKVSKL
4210 4220 4230 4240 4250
TQGQESPEHK EVGHLSNHWL ELCLQTSNVL LHREEDLQRT KDYHDRLNIV
4260 4270 4280 4290 4300
EVFLEKFTQE WDHLARSDAE STATHLEALR KLALALQERR FALEDLKEQK
4310 4320 4330 4340 4350
QKMIEHLKLD DTELVKEQSG HFEQRWIQLE DLIKRKIQLS VTTLEELNMV
4360 4370 4380 4390 4400
QSKLQELMEW AEEQQPNISE ALKHSPPPEL AQNFLMDHLT ICSEVEAKQV
4410 4420 4430 4440 4450
VLKGLKKDAD RVMTNLGLNE RQMLQKCLLE AQNHVDCLSE LVGQRRKHLN
4460 4470 4480 4490 4500
KTLSERTQFL LAAFQAMNQI QQHERKLKFH DHICLLPDDV RKQIRACKSA
4510 4520 4530 4540 4550
QVSLKAYQSE ISGLWSQGRD LMKDTTEQEK SEVLNKLQEL QNTYDAILEK
4560 4570 4580 4590 4600
CNQRLIELEK HMVSRKYFKE DLDKACHWVK QSDIVSFPEI NLMNSNSELY
4610 4620 4630 4640 4650
SQLAKYNHIL EQFPEYENLL LTLQKDGQEI LPSLNEMDRS YLEEKLSALP
4660 4670 4680 4690 4700
QQFSVIIALA KEKFCKVQEA IFARKEYSSL IELTTKALSE LEDQLLSMHK
4710 4720 4730 4740 4750
APSTLLAEEV VSLQQDYRNV LTEVVNLGTA VDELNQKKEA FRSTGQPWLP
4760 4770 4780 4790 4800
EEMLQLTTLY QKLKRQIEQK VNQFDDMMDA YQEHEKMCKQ LEIQLNSIKE
4810 4820 4830 4840 4850
DQTKLNKKTL PAEEKLKMYH SLAGNLQDAG NLLKRLAEHL ETLSSQLDPC
4860 4870 4880 4890 4900
VHEEANNQVR TWQDMMKTLH TAIGDIVMEC ENRLVQSIDF QTEICRSLEW
4910 4920 4930 4940 4950
LRHIKAELND PLNIDLKLND IQEEIRKVQI QQEEVQSSLR IMRALSNKEK
4960 4970 4980 4990 5000
EKYMKAKELI PTDLENSLAE LSELDEEVQE AVFKRQEKLI QLHSMCQRYY
5010 5020 5030 5040 5050
HVTQTASDWL EDAQELLQLT RNGLDMENSE ENLRDHIDFF STKKQFQVHL
5060 5070 5080 5090 5100
EELWSLISEI ETFIHVTGKE ELIKNVKALE EKGKESEQEA QCQNELLQSC
5110 5120 5130 5140 5150
ASQWQEYQIA RQDVIDLMNE SEKKLSEFSV AKATSMLEAE EKLISHKLLV
5160 5170 5180 5190 5200
STVNSFHEKI TSLEEKACHL EKMGNDASKA TISRSMTTVW QRWTRLRSIS
5210 5220 5230 5240 5250
QEQERILDES MQKWNEFNIK MQKATDTLDQ LQDRLPESSV EKASKNELLD
5260 5270 5280 5290 5300
LLDYHSNFSL ELEQQLSSLG LLKQHAFSVL RDIEVSSGSQ EQMPIMQEIK
5310 5320 5330 5340 5350
AMRDRYLNMQ QKVKRSGKVV KQELKERKEV ESEINKVKSW IQETKEYLLN
5360 5370 5380 5390 5400
PTTEITSQLE ELQGLTNEAT LHRQTVEKMA EQQQNKYLGL YTILPSELSL
5410 5420 5430 5440 5450
QLAEVGLALL NIHEQIQAKE KEAQQSKTLN QEFGQKIQEI AKELNSILLK
5460 5470 5480 5490 5500
LKEKTSNITQ AKVDQKVLGE ELDSCNIKLM ELDAAVQDFT EQNPQLSKQL
5510 5520 5530 5540 5550
TGKISKLTEL HQQTIRQAEY RGSKLNQAIS HLDEYNEMLE FILKWTEKAN
5560 5570 5580 5590 5600
ILIHGKITWN SAAQLRDQIM THQTMLEESG EIHGDLEVMN EKIEYLASVY
5610 5620 5630 5640 5650
LTEGMSQQVS ELGRQTQELQ QELKKRLQNL QDAAKDMKKF EIEVKGLQIA
5660 5670 5680 5690 5700
LEKAQASLTS SEFGRLSLKE QLSHRQHLLS EMESLKPKVR AVHICQSALR
5710 5720 5730 5740 5750
IPEEVVTSLP ICHVAVRLQE DASHLQHTAI QQYNVMQEAV VQYEQYEQEM
5760 5770 5780 5790 5800
KHLQQLIEKA HREIQDKPIS TSNIQELQAQ ISRHEELAQK IKGYQEQIAS
5810 5820 5830 5840 5850
LNSKCKMLTM KAKHATMLLT VTEVEGLSEG MEELDSDELL STHIAHPSVV
5860 5870 5880 5890 5900
MMTAGRCHTL LSPVTEESGE EGSNSEISSP PACRSPSPVA NTDASVNQDI
5910 5920 5930 5940 5950
AYYQALSAEQ LQTEASKIQP STSSTQESCE PGLESGTSTK LDDLQRSWET
5960 5970 5980 5990 6000
LKNVISEKQR SLYEALERQQ KYQDSLQSIS TKMEAIEVKL NETLGADKSP
6010 6020 6030 6040 6050
ESQMAEHQAL MDEILMLQDE ISELQTSLAE ELVSEPLDTD AADQLALQST
6060 6070 6080 6090 6100
LTVLAERMAT IKMKASGKRQ LLEEKLNEQL EEQRQEQALQ RYCSEADELD
6110 6120 6130 6140 6150
HWLLNTKATV DATSVLAEEP MDMDSQLVDC QNMLVEIEQK VVALSELSVH
6160 6170 6180 6190 6200
NENLLMEGKA HTKDEAEQLA VKLRTLKGSL LELQRVLHDK QINIQGVLQE
6210 6220 6230 6240 6250
KEECESDLVT SQSPSVQEWL AQARTTRSQQ QQSSLQRQKE LEKELAEQKD
6260 6270 6280 6290 6300
ILRSVASRGE EILTQHSAPD NLAPSKKSDV LTPELGLEGE KASTENQMKL
6310 6320 6330 6340 6350
KWESLHQEFT IKHKLLQNAL EQEEEQPLYS RPNRLMSALP LYKQEGQAQD
6360 6370 6380 6390 6400
KTSFTSLLVG LDEAFEDVSS QPGSTEKGNL LFEQKLYSGV SATSSWLDGV
6410 6420 6430 6440 6450
EERLFVATTL LPEVTETCLY NQEVLAKNIK EMSEKMDKNK NLFSHMFPEN
6460 6470 6480 6490 6500
ADNRDVIEDT LDCLLRRLIL LETLVSQRCQ HMKERLQSML SFQNDLKVMF
6510 6520 6530 6540 6550
ATLADNKYIA LQKLAEAVEC PETEQMQAIQ QAENGLKELE EGISELKKRG
6560 6570 6580 6590 6600
DKLQIDQPSM QELSKLQDIY DELIMIIRSR RSGLNQNLAL KEQYEQALQD
6610 6620 6630 6640 6650
LTELIETGKE KMTVDQKMIV SSKDEIKVLL DKHKEYFQGL ESHMILTETL
6660 6670 6680 6690 6700
FRKRSNFALV KETQFHVESM AQASAVLKQA HKRGVELEYI LETWTHLEED
6710 6720 6730 6740 6750
YQELIKQLES AETSMPSVGL VEESEERLAD RIALYQHLKS SLTEHQPKLY
6760 6770 6780 6790 6800
QVLDDGKRLL FSVTCSELET QLNQLGEHWL SNTSKVTKEL HRLETILKHW
6810 6820 6830 6840 6850
TRYQSESTEL IHWLQSAMER LEFWTQQSVT VPQELEMVRD HLNAFLEFSK
6860 6870 6880 6890 6900
EIEGKSSQKS TVLSIGNQLL RLKKVDIASL RAGLSQIDNQ WTELLTRVPV
6910 6920 6930 6940 6950
VQEKLHQLQM DKLPSRHAIT EVMSWISLME NIIAEDEDKI KNVVGHKAIQ
6960 6970 6980 6990 7000
DYLQKYKGFK IDINCKQLTV DFVNQSVLQI SSQDVESKRS DKTDFAEQLG
7010 7020 7030 7040 7050
VMNRRWQVLQ GLITEKIQLL EGFLESWTEY ENSVQCLKTW FETQQKRLEE
7060 7070 7080 7090 7100
QRRIGDQASV QNALKDCQEL EEHLKAKEKE IEKVEQSGFS LIQNKKEEVG
7110 7120 7130 7140 7150
VVVMDTLQKL NHYWANLDHM VGQLKILLQS VLEQWIIYKT AYEELNSYLM
7160 7170 7180 7190 7200
EARYSLSRFH LLTGSLDAVK VQVDNLQNLQ DELEKQEHRL QKFGSVANQL
7210 7220 7230 7240 7250
LKECQPPVTE AVTNTLKEMN LRWNNLLEEI AEHLHSSKGL LQLWQKYKNY
7260 7270 7280 7290 7300
YIQCSSTVQQ YEDRTNELLK AATNKEITDD EVTTWIHDCN DLLKGMKTIQ
7310 7320 7330 7340 7350
DSLFVLHELG EQLKQQVDPS AGAAIQSGQL SLSQKLSSLE HTLGRQQSTL
7360 7370 7380 7390 7400
QAGVQDYQTF TKTLGRLEGW ILQAGEILKA QDPSHSSDLS IIRNRMEELK
7410 7420 7430 7440 7450
CQMLKFSSMA PDLDRLNELG YRLPLNDKEI KRMQNLNRNW SMISSQTTER
7460 7470 7480 7490 7500
FSKLQSFMLQ QQTFLEKCET WMEFLVQTEQ KLAAEISGNY QLLLEQQRAH
7510 7520 7530 7540 7550
ELFQAEMFSR QQILHSIITD GQHLLEQGQV DDRDEFNLKL ALLSNQWQGV
7560 7570 7580 7590 7600
IHRAQQRRGI IDSQIRQWQR YREMSEKLRK WLVEASCQTA SGLSTVPIPL
7610 7620 7630 7640 7650
QQARALLDEI QLKEKVLLRQ QGSYILTVEG GKQLLLCADG ETETTLQTEL
7660 7670 7680 7690 7700
SEIQERWKLA NLRLEEQKKQ LMYLLKDWEK CEKAISDSLT KLKSFKRKLS
7710 7720 7730 7740 7750
QPLPEHHDEL HTEQIRCKEL ENAAEGWTDD LSQLNLLKET LSAYISADDI
7760 7770 7780 7790 7800
SVLSERIKLL HRHWEELCHQ VSLRRQQVTE RLNEWALFSE KNKELCEWLT
7810 7820 7830 7840 7850
QMESKVSQNG EILIEEMIEK LKKDYQDEIA VAQENKIQLQ QMGERLAKAS
7860 7870 7880 7890 7900
HESKAMEIEY KLGKVNDRWQ HLLDLIAARM KKLKETLVAV QQLDKNMSIL
7910 7920 7930 7940 7950
KSWLAHIESE LSKPIVYETC DSEEIQRKLN EQQELQRDIE KHSTGVASVL
7960 7970 7980 7990 8000
NLCEVLLHDC DACATETECD SIQQATRNLD RRWRNICAMS MERRLKIEET
8010 8020 8030 8040 8050
WRLWQKFLDD YSRFEDWLKI SEKTAAFPSS SGVLYTVAKE ELKKFEAFQR
8060 8070 8080 8090 8100
QVHESLTQLE LINKQYRRLA RENRTDSACS LKQMVHEGNQ RWDNLQKRVT
8110 8120 8130 8140 8150
SILRRLKHFI GQREEFETAR DNILVWLTEM DLQLTNIEHF SECDVQAKIK
8160 8170 8180 8190 8200
QLKAFQQEIS LNNNKIEQII AQGEQLIEKS EPLDAAVIEE ELDELRRYCQ
8210 8220 8230 8240 8250
EVFGRVERYH KKLIRLPLTD DEHDLSDHEV DLDESADLSD IHWHDKSADS
8260 8270 8280 8290 8300
VLSPHPSSHL SLSLPQPLRS ERSGRDTPAS VDSIPLEWDH DYDLSRDLET
8310 8320 8330 8340 8350
AVARALHSEE EDSQEDKEFY LRGATSLAGE PSSLETHIRQ LDKALDTSRF
8360 8370 8380 8390 8400
QIQQTENIIR SKTPTGPELD SSYKGYMKLL SECSGSIDSV RRLEFKLKEE
8410 8420 8430 8440 8450
EEKLSGFLNL NSTETQTAGV IDRWELIQAQ ALSKELRMKQ NLQQWQQFIS
8460 8470 8480 8490 8500
DLNNVWIWLG ETEEELEQLR CLDLSTNIQT IELRIKKLKE LQKTVDHRKA
8510 8520 8530 8540 8550
IILSINLCSS EFMQSDSEEN KKLQERLSQM NMRWDHVCTM LDEWRCSLQN
8560 8570 8580 8590 8600
ALMQCQDFHE MSHGLLLWLE NIDRRKNEIV PINPNLDSDT LQDHHRLLMQ
8610 8620 8630 8640 8650
IRRELLESQL KVASLQDMSC QLLVNAEGKD CLEAKEKVHV IGNRLKILLK
8660 8670 8680 8690 8700
EVTHHIKELE KILDISSNQL DLSSWSSADE LDTSGSLSPV SGRSTPSRQR
8710 8720 8730 8740 8750
TPRGKCNVSQ PGPSVSSPHS RPRRAGSDSS HSDGQLVGRQ RPQRQQCFFL
8760 8770 8780 8790 8800
RVLRAALPLQ LLLLFLVGLA CLVPMTEEDY SCTLSNNFAR SFHPMLRYTN

GPPPL
Length:8,805
Mass (Da):1,018,058
Last modified:June 26, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC270BAA3BEE73612
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AAWZ02022316 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSACAT00000006187; ENSACAP00000006053; ENSACAG00000005645

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAWZ02022316 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi28377.ENSACAP00000006053

Genome annotation databases

EnsembliENSACAT00000006187; ENSACAP00000006053; ENSACAG00000005645

Phylogenomic databases

eggNOGiKOG0516, Eukaryota
GeneTreeiENSGT00940000154481
HOGENOMiCLU_000025_1_0_1
InParanoidiH9GB25
TreeFamiTF329280

Gene expression databases

BgeeiENSACAG00000005645, Expressed in testis and 14 other tissues

Family and domain databases

CDDicd00014, CH, 2 hits
Gene3Di1.10.418.10, 2 hits
InterProiView protein in InterPro
IPR001589, Actinin_actin-bd_CS
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR012315, KASH
IPR018159, Spectrin/alpha-actinin
IPR002017, Spectrin_repeat
IPR030265, SYNE1
PANTHERiPTHR14514:SF3, PTHR14514:SF3, 1 hit
PfamiView protein in Pfam
PF00307, CH, 2 hits
PF10541, KASH, 1 hit
PF00435, Spectrin, 9 hits
SMARTiView protein in SMART
SM00033, CH, 2 hits
SM01249, KASH, 1 hit
SM00150, SPEC, 37 hits
SUPFAMiSSF47576, SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS00019, ACTININ_1, 1 hit
PS00020, ACTININ_2, 1 hit
PS50021, CH, 2 hits
PS51049, KASH, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH9GB25_ANOCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H9GB25
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 16, 2012
Last sequence update: June 26, 2013
Last modified: December 2, 2020
This is version 59 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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