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Entry version 38 (07 Oct 2020)
Sequence version 2 (26 Jun 2013)
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Protein

LisH domain-containing protein

Gene

NPAT

Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
LisH domain-containing proteinInterPro annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NPATImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnolis carolinensis (Green anole) (American chameleon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri28377 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaIguaniaDactyloidaeAnolis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001646 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSACAG00000006020, Expressed in forelimb bud and 14 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
28377.ENSACAP00000005890

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini3 – 35LisHInterPro annotationAdd BLAST33

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni203 – 253DisorderedSequence analysisAdd BLAST51
Regioni590 – 623DisorderedSequence analysisAdd BLAST34
Regioni639 – 732DisorderedSequence analysisAdd BLAST94
Regioni978 – 1021DisorderedSequence analysisAdd BLAST44
Regioni1070 – 1227DisorderedSequence analysisAdd BLAST158
Regioni1245 – 1271DisorderedSequence analysisAdd BLAST27
Regioni1284 – 1312DisorderedSequence analysisAdd BLAST29

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi220 – 240PolarSequence analysisAdd BLAST21
Compositional biasi643 – 657PolyampholyteSequence analysisAdd BLAST15
Compositional biasi658 – 706PolarSequence analysisAdd BLAST49
Compositional biasi992 – 1006PolarSequence analysisAdd BLAST15
Compositional biasi1070 – 1098PolarSequence analysisAdd BLAST29
Compositional biasi1147 – 1164PolyampholyteSequence analysisAdd BLAST18
Compositional biasi1165 – 1207PolarSequence analysisAdd BLAST43

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QYUR, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000012388

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_004845_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
H9GAV0

TreeFam database of animal gene trees

More...
TreeFami
TF332825

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006594, LisH
IPR031442, NPAT_C

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15712, NPAT_C, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50896, LISH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

H9GAV0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLLPSDVARL VLGYLQQERL LATCRSFILE SSDLKEYAEH CTGEGFVPAC
60 70 80 90 100
LLSLFGKNLI TILNEYIAMK SKEATNDVPA MMSSLWKKLD YTLSQIRTMQ
110 120 130 140 150
MSSGFAAHQR SRTRCAIADM KKQRCLQQSS SNLGVSSVVH PPGPLNSTPM
160 170 180 190 200
TATQVILKSV VTPSLSQTKM GSSIIHQAQV QESHVNADSL NLVSTFQERK
210 220 230 240 250
LPSNVMSPVK RKNDSQKKKT LVSSESQSSN CDSQDSLTPE EESSPMEEES
260 270 280 290 300
EQLELMDSGL PQMIIENARE KILSNKCLQE KLAENINKFL GSDGNISQAV
310 320 330 340 350
KQAESGPAIQ ESSIDEFLNL QQGEIHMTEE AIHEILEQTE SDPAFQGLFD
360 370 380 390 400
VFDFGKTKVN RNATHGLSTQ NGEVENTILV DEENLQALEC YIATKELGDN
410 420 430 440 450
PQGCLSYPGD DSKEASILKA DCSGRNGTLE ERFKMEGVVT GEFLGSAKET
460 470 480 490 500
SNSVSAEAET YECQSTIESV DNHVTHMEFS GGHHVGSYNQ QETAIRDCRI
510 520 530 540 550
GKDSLRQDIQ TSPELQYDHI VTPQIPLSDN TKCISVPDNI SSEKTNAELL
560 570 580 590 600
IPPRTGDSEI LTRTDIVIPS HSAEFVKSME QISEQSAVFP EPDKQNQSNP
610 620 630 640 650
VLSQCQSQEK IESDSTTALG NTYDPDSIEV QLEVVDTSNS LHSNDQPDHH
660 670 680 690 700
ESCPEHQMQT EDSGMSQVDI QKPSSSTKTD TDGAFLASDS ESPTENHSTS
710 720 730 740 750
SALCPSPTVE PMGESSPGNK VGASISSSTQ ATSVDPSSIV SLKIIISDDP
760 770 780 790 800
FLSSETELNN AVSSITGKNM PTIILSSPAK SPAKITVPSK CVSSEESERI
810 820 830 840 850
ADAGLIEQNL LLVGPQDSAA RKLNVENEEC TVFSISGASN VAKDGGIMQL
860 870 880 890 900
MPATTTPFTN SNSVYIATCM TEPAALSTSV TPSNLVMLPS GSTSLASQIS
910 920 930 940 950
TPQPLRTPPR TNGLFTMNPP MSPNFPHGSA IIIASPVQPV LQGMVGMIPV
960 970 980 990 1000
SILGQGGNAF SDPSQQILHL PIQTSLGSGG IPKLPLPPKS QRIPKNKSNT
1010 1020 1030 1040 1050
GKLVMSGSEP LNCPGSRAQR IGSLDKNACG DAKKKLEIVA VDTTSPSSKQ
1060 1070 1080 1090 1100
NESHRRVLFF DKALAIPVGS TQVSQKERTE NPLGPGNSPS AVLSSTKIQS
1110 1120 1130 1140 1150
SKRERERTLP RILCKPNVSH RSSAVKENLP EKKGSSPGLA SDVLRKQTAN
1160 1170 1180 1190 1200
KENELERNVD KTPQKQEVET LSSGQQNQNE KNTSSSQELS KKQGLQTNTN
1210 1220 1230 1240 1250
SKNSGVLPSK EPKKDQTKSP NQSHSLASPL AKQAVEMLHD IQRQSPASKL
1260 1270 1280 1290 1300
PESGDLPVPR TPSGMGDRHT EDTFDIVRTP TCRRYSEDST TPRIMVPPAT
1310 1320 1330 1340 1350
PDLPACSPAS ETSSENSVSM AAHTLMILSR AAIARTSTAL KDNTQPFKSL
1360 1370 1380 1390 1400
KSVAKKRKQE DVECEKGSRP ANKKDLQNFT VPIKKKKVKK KLPVAFPAGM
1410
DVDKFLLSLH YDE
Length:1,413
Mass (Da):152,929
Last modified:June 26, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7FF775D9B867F188
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AAWZ02031581 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSACAT00000006019; ENSACAP00000005890; ENSACAG00000006020

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAWZ02031581 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi28377.ENSACAP00000005890

Genome annotation databases

EnsembliENSACAT00000006019; ENSACAP00000005890; ENSACAG00000006020

Phylogenomic databases

eggNOGiENOG502QYUR, Eukaryota
GeneTreeiENSGT00390000012388
HOGENOMiCLU_004845_0_0_1
InParanoidiH9GAV0
TreeFamiTF332825

Gene expression databases

BgeeiENSACAG00000006020, Expressed in forelimb bud and 14 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR006594, LisH
IPR031442, NPAT_C
PfamiView protein in Pfam
PF15712, NPAT_C, 1 hit
PROSITEiView protein in PROSITE
PS50896, LISH, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH9GAV0_ANOCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H9GAV0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 16, 2012
Last sequence update: June 26, 2013
Last modified: October 7, 2020
This is version 38 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteomeImported
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