UniProtKB - H9GAT8 (H9GAT8_ANOCA)
Protein
Submitted name:
Uncharacterized protein
Gene
SHC4
Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Functioni
GO - Molecular functioni
- protein domain specific binding Source: Ensembl
- protein kinase binding Source: GO_Central
- receptor tyrosine kinase binding Source: GO_Central
GO - Biological processi
- apoptotic process Source: Ensembl
- intracellular signal transduction Source: InterPro
- positive regulation of cell population proliferation Source: Ensembl
- regulation of gene expression Source: Ensembl
- stem cell differentiation Source: Ensembl
- transmembrane receptor protein tyrosine kinase signaling pathway Source: GO_Central
Names & Taxonomyi
Protein namesi | Submitted name: Uncharacterized proteinImported |
Gene namesi | Name:SHC4Imported |
Organismi | Anolis carolinensis (Green anole) (American chameleon)Imported |
Taxonomic identifieri | 28377 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Iguania › Dactyloidae › Anolis |
Proteomesi |
|
Subcellular locationi
Plasma Membrane
- plasma membrane Source: GO_Central
Expressioni
Gene expression databases
Bgeei | ENSACAG00000005944, Expressed in adrenal gland and 11 other tissues |
Interactioni
GO - Molecular functioni
- protein domain specific binding Source: Ensembl
- protein kinase binding Source: GO_Central
- receptor tyrosine kinase binding Source: GO_Central
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000005868 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 189 – 357 | PIDInterPro annotationAdd BLAST | 169 | |
Domaini | 524 – 615 | SH2InterPro annotationAdd BLAST | 92 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 39 – 59 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 131 – 160 | DisorderedSequence analysisAdd BLAST | 30 | |
Regioni | 440 – 515 | DisorderedSequence analysisAdd BLAST | 76 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 445 – 475 | PolarSequence analysisAdd BLAST | 31 | |
Compositional biasi | 494 – 515 | PolarSequence analysisAdd BLAST | 22 |
Keywords - Domaini
SH2 domainPROSITE-ProRule annotationARBA annotationPhylogenomic databases
eggNOGi | KOG3697, Eukaryota |
GeneTreei | ENSGT00950000182870 |
HOGENOMi | CLU_029532_2_0_1 |
InParanoidi | H9GAT8 |
OMAi | HILECPN |
TreeFami | TF315807 |
Family and domain databases
CDDi | cd01209, PTB_Shc, 1 hit cd09925, SH2_SHC, 1 hit |
Gene3Di | 2.30.29.30, 1 hit 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR011993, PH-like_dom_sf IPR006019, PID_Shc-like IPR006020, PTB/PI_dom IPR000980, SH2 IPR036860, SH2_dom_sf IPR029596, SHC4 IPR035676, SHC_SH2 |
PANTHERi | PTHR10337:SF12, PTHR10337:SF12, 1 hit |
Pfami | View protein in Pfam PF00640, PID, 1 hit PF00017, SH2, 1 hit |
PRINTSi | PR00401, SH2DOMAIN PR00629, SHCPIDOMAIN |
SMARTi | View protein in SMART SM00462, PTB, 1 hit SM00252, SH2, 1 hit |
SUPFAMi | SSF55550, SSF55550, 1 hit |
PROSITEi | View protein in PROSITE PS01179, PID, 1 hit PS50001, SH2, 1 hit |
i Sequence
Sequence statusi: Complete.
H9GAT8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRERVPQSLS GHILYVGLAR DPGMLHRAKY SRFRNESVTP LEEDAHGGPL
60 70 80 90 100
HLKASASSPA SAPNIPIEEV AIGTPNSSLA LGTLIPRMAN IKLANPSALP
110 120 130 140 150
SFKNFCLRTK EVPRIKLTEC TTVPASPALP DINSSTCLST SHSRSDEKTP
160 170 180 190 200
KANPNLQGDS FLLSSEDSAI LSKLDKDLGH KGESRLEAGI SYTVRYMGCI
210 220 230 240 250
EVLQSMRSLD FGTRTHVTRE AISRLCEAHM GPQKKPPAKF LSPVLGKSNL
260 270 280 290 300
QFSGMNIKLT ISTTSLTLLN VETQQIIANH HMQSISFASG GDPDTTDYVA
310 320 330 340 350
YVAKDPVNQR ACHILECPTG VAQEVINTIG QAFELRFKQY LKNPSAVITS
360 370 380 390 400
NEREVVNLGG STWNIQEKEG HEYYNEIPGK EPLAGGLLDA RVKIPSEERI
410 420 430 440 450
HCPLHYEKQY SPTESPKSMN IYENCPEDCK SADRCREKAQ AGKKDAPSLT
460 470 480 490 500
NTSKLDLFDD PQYINTQNVQ TTPCSARSPP PLPVCRSPVH RSESTEAVEQ
510 520 530 540 550
IPSSNAAGPG GVTSVKQQLQ DEECYHGKLT RKTAESLLVS DGDFLIREST
560 570 580 590 600
SSPGQYVLSG LQGGQAKHLL LVDPEGKVRT KDHVFDSVSH LIRYHMENKL
610
PIISSGSELN LSQPVKK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAWZ02029372 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENSACAT00000005997; ENSACAP00000005868; ENSACAG00000005944 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAWZ02029372 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000005868 |
Genome annotation databases
Ensembli | ENSACAT00000005997; ENSACAP00000005868; ENSACAG00000005944 |
Phylogenomic databases
eggNOGi | KOG3697, Eukaryota |
GeneTreei | ENSGT00950000182870 |
HOGENOMi | CLU_029532_2_0_1 |
InParanoidi | H9GAT8 |
OMAi | HILECPN |
TreeFami | TF315807 |
Gene expression databases
Bgeei | ENSACAG00000005944, Expressed in adrenal gland and 11 other tissues |
Family and domain databases
CDDi | cd01209, PTB_Shc, 1 hit cd09925, SH2_SHC, 1 hit |
Gene3Di | 2.30.29.30, 1 hit 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR011993, PH-like_dom_sf IPR006019, PID_Shc-like IPR006020, PTB/PI_dom IPR000980, SH2 IPR036860, SH2_dom_sf IPR029596, SHC4 IPR035676, SHC_SH2 |
PANTHERi | PTHR10337:SF12, PTHR10337:SF12, 1 hit |
Pfami | View protein in Pfam PF00640, PID, 1 hit PF00017, SH2, 1 hit |
PRINTSi | PR00401, SH2DOMAIN PR00629, SHCPIDOMAIN |
SMARTi | View protein in SMART SM00462, PTB, 1 hit SM00252, SH2, 1 hit |
SUPFAMi | SSF55550, SSF55550, 1 hit |
PROSITEi | View protein in PROSITE PS01179, PID, 1 hit PS50001, SH2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | H9GAT8_ANOCA | |
Accessioni | H9GAT8Primary (citable) accession number: H9GAT8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 16, 2012 |
Last sequence update: | May 16, 2012 | |
Last modified: | December 2, 2020 | |
This is version 53 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |