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Entry version 53 (02 Dec 2020)
Sequence version 1 (16 May 2012)
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Protein

Anion exchange protein 2

Gene

SLC4A2

Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plasma membrane anion exchange protein of wide distribution.ARBA annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAnion exchangeARBA annotation, AntiportARBA annotation, Ion transport, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Anion exchange protein 2ARBA annotation
Alternative name(s):
Solute carrier family 4 member 2ARBA annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC4A2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnolis carolinensis (Green anole) (American chameleon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri28377 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaIguaniaDactyloidaeAnolis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001646 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei719 – 739HelicalSequence analysisAdd BLAST21
Transmembranei746 – 768HelicalSequence analysisAdd BLAST23
Transmembranei805 – 833HelicalSequence analysisAdd BLAST29
Transmembranei885 – 903HelicalSequence analysisAdd BLAST19
Transmembranei923 – 939HelicalSequence analysisAdd BLAST17
Transmembranei976 – 995HelicalSequence analysisAdd BLAST20
Transmembranei1016 – 1039HelicalSequence analysisAdd BLAST24
Transmembranei1076 – 1095HelicalSequence analysisAdd BLAST20
Transmembranei1102 – 1121HelicalSequence analysisAdd BLAST20

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

MethylationARBA annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSACAG00000005372, Expressed in kidney and 12 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
28377.ENSACAP00000005492

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini354 – 625Band_3_cytoInterPro annotationAdd BLAST272
Domaini872 – 1153HCO3_cotranspInterPro annotationAdd BLAST282

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 265DisorderedSequence analysisAdd BLAST265
Regioni295 – 320DisorderedSequence analysisAdd BLAST26
Regioni646 – 665DisorderedSequence analysisAdd BLAST20

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 30Pro-richSequence analysisAdd BLAST30
Compositional biasi35 – 94PolyampholyteSequence analysisAdd BLAST60
Compositional biasi121 – 142AcidicSequence analysisAdd BLAST22
Compositional biasi183 – 202PolarSequence analysisAdd BLAST20
Compositional biasi300 – 320PolyampholyteSequence analysisAdd BLAST21
Compositional biasi646 – 662PolyampholyteSequence analysisAdd BLAST17

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the anion exchanger (TC 2.A.31) family. [View classification]ARBA annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1172, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158259

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002289_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
H9GAE4

Identification of Orthologs from Complete Genome Data

More...
OMAi
WITCATA

TreeFam database of animal gene trees

More...
TreeFami
TF313630

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.930.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001717, Anion_exchange
IPR002978, Anion_exchange_2
IPR013769, Band3_cytoplasmic_dom
IPR011531, HCO3_transpt_C
IPR003020, HCO3_transpt_euk
IPR016152, PTrfase/Anion_transptr

The PANTHER Classification System

More...
PANTHERi
PTHR11453, PTHR11453, 1 hit
PTHR11453:SF14, PTHR11453:SF14, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07565, Band_3_cyto, 1 hit
PF00955, HCO3_cotransp, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00165, ANIONEXCHNGR
PR01231, HCO3TRNSPORT

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55804, SSF55804, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

H9GAE4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
PCSRSPRPPR PLSWQPEQEA PGPSSSSPPP FGPQEEERDL SKALRVERFD
60 70 80 90 100
EILQDSHPRN VEEAGRSYSE EDFEYHRQSS HHIHHPLSSH LPSEGRRKKG
110 120 130 140 150
KKKAAPRPQR ASLPGETPII PEEEAEGEEE EEGEEEAGDT AEEAEQSPPQ
160 170 180 190 200
RRPQGGSRDG VQFFLPEDDA VDRQAEGGYS TPGRLPSPTS DVRETPGPSS
210 220 230 240 250
RGRRPSSPDE EDPEGLGAEG GSSGRLPSKP QPGHRSYNLN ERRRIGSQTG
260 270 280 290 300
IDQARLPKVP TDESEAQTLA SVDLDYMKSH RFEDVPGVRR HLVRKSTKGQ
310 320 330 340 350
VVHLGKDRRE SSTRTRKTDR QPHEVFVELN ELIVDKNQEM QWKETARWIK
360 370 380 390 400
FEEDVEEETD RWGKPHVASL SFRSLLELRR TLSHGAVLLD LDQKTLPGVA
410 420 430 440 450
HQVVEQMIIS DQIRAEDRAN VLRALLLKHS HPSDEKEFSF PRNISAGSLG
460 470 480 490 500
SLLSHHHSTN HIGDSAEPAV TDPLIGGHME QETRVDIEKE KEVPSPVVSS
510 520 530 540 550
ISRSKSKHEL KLLEKIPENA EATVVLVGSV DFLDQPTMAF VRLQEAAQLD
560 570 580 590 600
AVLEVPIPVR FLFVLLGPQS ANMDYHEIGR SISTLMSDKQ FHEAAYLADD
610 620 630 640 650
RQDLLHAINE FLDCSVVLPP SEVQGEELLR SVANFQREML RRREEQERRQ
660 670 680 690 700
FLGPEAEPKS PEEKGTCGIY SRVESSAARD RYQLRVGNRR YAGYSSNVFK
710 720 730 740 750
KGKHLVLSIY IKGLPAHCLI SHFSVYLFIC SIYIPPFFLT PKGTQSLLII
760 770 780 790 800
QHILLSNVLP ACLCWITCAT ARPNVGASLN LVFVNSAAIL FCFQEKPPKE
810 820 830 840 850
EIPLVGVFLF FFSVLATGAG PRCCASIALL YIYEEGLLLI SIFQAHPLNN
860 870 880 890 900
CLRANTTDHP MDPEGNWTTG NTTAFVGELT GQPNTALLSL VLMGGTFFIG
910 920 930 940 950
FFLRKFKNSR FFPGRVRRMI GDFGVPIAIL VMVLVDYNIR DTYTQKLSVP
960 970 980 990 1000
RGLSVTDPDK RGWVINPLGE VDPFPVWMMV GCGLPAMLVF ILIFMETQIT
1010 1020 1030 1040 1050
TLIISKKERK LRKGSGFHLD LLIIVALGGF CALFGLPWLT AATVRSVTHT
1060 1070 1080 1090 1100
NALTVMSKAV APGDKPKVQE VREQRVTGFL VAFLVGLSIV ISDLLRKIPL
1110 1120 1130 1140 1150
SVLFGIFLYM GITSLNGIQF YERLKLLLMP AKHHPEVSYV KKVRTVRMHL
1160 1170 1180 1190 1200
FTLQQLSCLA VLGAVSRNWG SPCLLWRVLL TSPSLSLILL PEAPRDPRCP
1210 1220
CILDAAEVEP ILDPRTGQDE YYEMPMPV
Length:1,228
Mass (Da):137,270
Last modified:May 16, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDBC139C54D49C970
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAWZ02036038 Genomic DNA No translation available.
AAWZ02036039 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSACAT00000005612; ENSACAP00000005492; ENSACAG00000005372

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAWZ02036038 Genomic DNA No translation available.
AAWZ02036039 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi28377.ENSACAP00000005492

Genome annotation databases

EnsembliENSACAT00000005612; ENSACAP00000005492; ENSACAG00000005372

Phylogenomic databases

eggNOGiKOG1172, Eukaryota
GeneTreeiENSGT00940000158259
HOGENOMiCLU_002289_1_0_1
InParanoidiH9GAE4
OMAiWITCATA
TreeFamiTF313630

Gene expression databases

BgeeiENSACAG00000005372, Expressed in kidney and 12 other tissues

Family and domain databases

Gene3Di3.40.930.10, 1 hit
InterProiView protein in InterPro
IPR001717, Anion_exchange
IPR002978, Anion_exchange_2
IPR013769, Band3_cytoplasmic_dom
IPR011531, HCO3_transpt_C
IPR003020, HCO3_transpt_euk
IPR016152, PTrfase/Anion_transptr
PANTHERiPTHR11453, PTHR11453, 1 hit
PTHR11453:SF14, PTHR11453:SF14, 1 hit
PfamiView protein in Pfam
PF07565, Band_3_cyto, 1 hit
PF00955, HCO3_cotransp, 1 hit
PRINTSiPR00165, ANIONEXCHNGR
PR01231, HCO3TRNSPORT
SUPFAMiSSF55804, SSF55804, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH9GAE4_ANOCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H9GAE4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 16, 2012
Last sequence update: May 16, 2012
Last modified: December 2, 2020
This is version 53 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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