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UniProtKB - H9G9Y7 (H9G9Y7_ANOCA)

Entry version 40 (12 Aug 2020)
Sequence version 2 (26 Jun 2013)
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Protein

53-BP1_Tudor domain-containing protein

Gene

LOC103282074

Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • histone binding Source: GO_Central
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
53-BP1_Tudor domain-containing proteinInterPro annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LOC103282074Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnolis carolinensis (Green anole) (American chameleon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri28377 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Iguania › Dactyloidae › Anolis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001646 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSACAG00000005169, Expressed in heart and 14 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		28377.ENSACAP00000005073

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini743 – 86353-BP1_TudorInterPro annotationAdd BLAST121

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 246DisorderedSequence analysisAdd BLAST246
Regioni259 – 293DisorderedSequence analysisAdd BLAST35
Regioni308 – 497DisorderedSequence analysisAdd BLAST190
Regioni534 – 591DisorderedSequence analysisAdd BLAST58
Regioni616 – 743DisorderedSequence analysisAdd BLAST128
Regioni885 – 974DisorderedSequence analysisAdd BLAST90
Regioni990 – 1012DisorderedSequence analysisAdd BLAST23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi28 – 45PolarSequence analysisAdd BLAST18
Compositional biasi193 – 212PolarSequence analysisAdd BLAST20
Compositional biasi374 – 398PolyampholyteSequence analysisAdd BLAST25
Compositional biasi430 – 446PolarSequence analysisAdd BLAST17
Compositional biasi551 – 591PolarSequence analysisAdd BLAST41
Compositional biasi632 – 649PolyampholyteSequence analysisAdd BLAST18
Compositional biasi688 – 709PolarSequence analysisAdd BLAST22
Compositional biasi912 – 927PolarSequence analysisAdd BLAST16

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3548, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000011891

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_297649_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		H9G9Y7

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.30.30.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR015125, 53-BP1_Tudor
IPR014722, Rib_L2_dom2

Pfam protein domain database

More...Pfami		View protein in Pfam
PF09038, 53-BP1_Tudor, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

H9G9Y7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDVAPVASGE PAAADSAEEP PSQAPFPTSP GTALQLLSSQ SPPLERPESP 
        60         70         80         90        100
GALGTELPTG REKKASEEGE GAVPPRTAQE EPDKARPADC SVQGSDEVPA 
       110        120        130        140        150
ALPGSQPDAS SKEISTISHL LGKQEDEAVA AGAAEEAGEG QWGQGAPNPS 
       160        170        180        190        200
DGLAVEGSSF PKEGSAFPPL AGFTPPLIGR LKRSPRHSTP NEVGGCPDSS 
       210        220        230        240        250
IATSNITAES AHAVTLGSPL ASAEMEEESG QGAAGQGGQE AEAEAVVAKG 
       260        270        280        290        300
KLSLQMGLGT PVAEESEGSM PFSLEKPAAD REKNGSLPGT VSRAQKMPSV 
       310        320        330        340        350
FARVYEALHA GQSQGPKPPS SPFRGDLFHF PNSREEEEEK EEKEEPTPGS 
       360        370        380        390        400
RQKAARLDPR PCGQALRGDG PAGCTEEAAE ERMETEAVEA HEGEAGWREA 
       410        420        430        440        450
KGPGSAPPPK GSDPTHSPRP PASSGVRGPA SIVSVATQTG ACSRAEVGTS 
       460        470        480        490        500
MAQVRPEMQD AEAQTEEGRR GTPGRTQTTE APLNKNDKED LASSCQPRVH 
       510        520        530        540        550
VLQRHVRTVR EVRTVVTRVI TDVYYKDGAE VERKVVEESE EPVVERQESE 
       560        570        580        590        600
AALSPSRTGG SSLTPGDLGD ISSFSSKSSG PQQASSGGSG ASSFINSGII 
       610        620        630        640        650
AGPHDSALPG VRKPSFAKAK QAFSPSPRKG GLLTQRDHRA AEGHQEEEGL 
       660        670        680        690        700
GGNARPALRG QARRARPAAR TTGKSMVWGG GVGCGESEAQ ELSSTTSLSV 
       710        720        730        740        750
ASQENHSVPP AEASLHCRSS SPEIPLQELP APPSPSPSSP SRDSLVGLRV 
       760        770        780        790        800
VAKWSSNGYF YSGTITQDVG STKYKLLFDD GYECEVPGRD ILLCDPLPLE 
       810        820        830        840        850
TEVTALSEDE YFSAGVVKGH RQELGELFYC VEKDGQQKWY RRAAVILSLE 
       860        870        880        890        900
QGNRLREQFG LGPFEPLTPL AKAADISLDN LVEGKRKRRN MGSPGPSLRT 
       910        920        930        940        950
GLLLRKAPDS PQSPHRLQSS KRKLNTSDGE QSPAKRGRRT APPHTGAAGA 
       960        970        980        990       1000
KETGSPPCSG GDAGAAEERW GPLPHNKTLF LGYAFLLTVA GPTDRPSSGQ 
      1010 
ALAVSSGEEE GE
Length:1,012
Mass (Da):105,842
Last modified:June 26, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6A476C07F4D1EA40
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AAWZ02036426 Genomic DNA No translation available.
AAWZ02036427 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSACAT00000005188; ENSACAP00000005073; ENSACAG00000005169

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAWZ02036426 Genomic DNA No translation available.
AAWZ02036427 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi28377.ENSACAP00000005073

Genome annotation databases

EnsembliENSACAT00000005188; ENSACAP00000005073; ENSACAG00000005169

Phylogenomic databases

eggNOGiKOG3548, Eukaryota
GeneTreeiENSGT00390000011891
HOGENOMiCLU_297649_0_0_1
InParanoidiH9G9Y7

Gene expression databases

BgeeiENSACAG00000005169, Expressed in heart and 14 other tissues

Family and domain databases

Gene3Di2.30.30.30, 1 hit
InterProiView protein in InterPro
IPR015125, 53-BP1_Tudor
IPR014722, Rib_L2_dom2
PfamiView protein in Pfam
PF09038, 53-BP1_Tudor, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH9G9Y7_ANOCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H9G9Y7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 16, 2012
Last sequence update: June 26, 2013
Last modified: August 12, 2020
This is version 40 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteomeImported
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Main funding by: National Institutes of Health

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