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Entry version 62 (29 Sep 2021)
Sequence version 2 (26 Jun 2013)
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Protein
Submitted name:

Microtubule associated monooxygenase, calponin and LIM domain containing 2

Gene

MICAL2

Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

FADARBA annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-bindingARBA annotation, MonooxygenaseARBA annotation, Oxidoreductase
LigandMetal-binding, NADPARBA annotation, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Microtubule associated monooxygenase, calponin and LIM domain containing 2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MICAL2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnolis carolinensis (Green anole) (American chameleon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri28377 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaIguaniaDactyloidaeAnolis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001646 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

SecretedARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

GlycoproteinARBA annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSACAG00000004829, Expressed in skeletal muscle tissue and 14 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
28377.ENSACAP00000004805

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini528 – 634Calponin-homology (CH)InterPro annotationAdd BLAST107
Domaini1026 – 1088LIM zinc-bindingInterPro annotationAdd BLAST63

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni678 – 710DisorderedSequence analysisAdd BLAST33
Regioni774 – 794DisorderedSequence analysisAdd BLAST21

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili850 – 870Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi678 – 695Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi696 – 710Polar residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Mical family.ARBA annotation
Belongs to the flavin monoamine oxidase family. FIG1 subfamily.ARBA annotation

Keywords - Domaini

Coiled coilSequence analysis, LIM domainPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1700, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158780

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000329_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
H9G9P0

Identification of Orthologs from Complete Genome Data

More...
OMAi
INDYMDT

Database of Orthologous Groups

More...
OrthoDBi
430978at2759

TreeFam database of animal gene trees

More...
TreeFami
TF324129

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00014, CH, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.418.10, 1 hit
3.50.50.60, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR002938, FAD-bd
IPR036188, FAD/NAD-bd_sf
IPR029939, MICAL2
IPR001781, Znf_LIM

The PANTHER Classification System

More...
PANTHERi
PTHR23167:SF39, PTHR23167:SF39, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00307, CH, 1 hit
PF01494, FAD_binding_3, 1 hit
PF00412, LIM, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00033, CH, 1 hit
SM00132, LIM, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47576, SSF47576, 1 hit
SSF51905, SSF51905, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50021, CH, 1 hit
PS00478, LIM_DOMAIN_1, 1 hit
PS50023, LIM_DOMAIN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

H9G9P0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPLGYSPLSS QNMEEKDNEK YNQAGQIFEN FVQASTCKGT IQAFNILTRY
60 70 80 90 100
LELDPLDNRN FYPKLKSKVT SWKAKALWNK LDKRASHKEY KRGKACVNTK
110 120 130 140 150
CLIVGGGPCG LRTAIELAFL GAKVVVVEKR DTFSRNNVLH LWPFTIHDLR
160 170 180 190 200
SLGAKKFYGK FCAGSIDHIS IRQLQLILFK IALMLGVEIH VNLEFIKVIE
210 220 230 240 250
PPEDQENQKI GWRAEFLPMD HPLSEYEFDV VIGADGRRNT LEGFRRKEFR
260 270 280 290 300
GKLAIAITAN FINRNTTAEA KVEEISGVAF IFNQKFFQDL KEETGIDLEN
310 320 330 340 350
IVYYKDSTHY FVMTAKKQSL LEKGVIIKDY IDTEMLLCAE NVDQDNLLSY
360 370 380 390 400
AREAADFATD YQLPALDFAI NHYGQPDVAM FDFTSMYASE NAALVRERHR
410 420 430 440 450
HQLLVALVGD SLVEPFWPMG TGCARGFLAA FDTAWMVKSW AQGKHPFDIL
460 470 480 490 500
AERESIYRLL PQTTPENITK NFDLYTIDPA TRYPNLNSSC VRPHQVKHLY
510 520 530 540 550
ITNELQSCPL ERSTSIRRSI GLSRQESDVR PNKLLTWCQK QTEGYRNVNI
560 570 580 590 600
TDLTSSWSSG LALCAIIHHF RPDLIDFDSL NEEDAVRNNQ LAFDIAEREF
610 620 630 640 650
GIPPVTTGKE MVSAGEPDKL SMVMYLSKFY ELFRGTPLRA VGTVGKQNGE
660 670 680 690 700
RNDLFSTKST NFIFNNYINL TFPRKRVPKA EENETNKRRR KSFINFEESS
710 720 730 740 750
SSLNHGTNSN NQIADVKEAM NGNKVKSMAT QLLAKFEENA PNISIRRQEL
760 770 780 790 800
VDQPALHLSP ESPVNPRFAK PKEPVNPRFA KPKEPTCNPP PPSKSQFQAI
810 820 830 840 850
ARADRVVRKP KQSLPEAPPV VRPLSCVEQT ELNSSLSETL ASSCPAAFAL
860 870 880 890 900
SGVLQRLQHV EEKINQKRAQ SLANREFHKK SIKEKAAHLA SMFGCVDIPK
910 920 930 940 950
NKLPTKGLSY SQHLSPSCLP SHDSAASSSS IDYSASPAIH SKKMTVGKVS
960 970 980 990 1000
RGIGAVAQVL VSLYMNDHRP SPLSTSLELN ESADGVVAAA ATFSTSSSAS
1010 1020 1030 1040 1050
PAFPSTAQSC QGSLRKEFPQ SIGGSDVCYF CKKRVYVMER LSAEGHFFHR
1060 1070 1080 1090 1100
ECFKCAICAT TLRLAMYAFD AEEGKFYCKL HFSQCKTKNT HRKRRAMLKS
1110 1120 1130 1140
HEKEEAELWK EEEPMSPETT SECAFAASSS SEDRSPVHFN IPVLHPLIG
Length:1,149
Mass (Da):129,233
Last modified:June 26, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA6311DB91E24699C
GO

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_008114147.1, XM_008115940.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSACAT00000004913; ENSACAP00000004805; ENSACAG00000004829
ENSACAT00000041478; ENSACAP00000031977; ENSACAG00000004829
ENSACAT00000058720; ENSACAP00000026366; ENSACAG00000004829

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100564862

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
acs:100564862

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_008114147.1, XM_008115940.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi28377.ENSACAP00000004805

Genome annotation databases

EnsembliENSACAT00000004913; ENSACAP00000004805; ENSACAG00000004829
ENSACAT00000041478; ENSACAP00000031977; ENSACAG00000004829
ENSACAT00000058720; ENSACAP00000026366; ENSACAG00000004829
GeneIDi100564862
KEGGiacs:100564862

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9645

Phylogenomic databases

eggNOGiKOG1700, Eukaryota
GeneTreeiENSGT00940000158780
HOGENOMiCLU_000329_0_1_1
InParanoidiH9G9P0
OMAiINDYMDT
OrthoDBi430978at2759
TreeFamiTF324129

Gene expression databases

BgeeiENSACAG00000004829, Expressed in skeletal muscle tissue and 14 other tissues

Family and domain databases

CDDicd00014, CH, 1 hit
Gene3Di1.10.418.10, 1 hit
3.50.50.60, 1 hit
InterProiView protein in InterPro
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR002938, FAD-bd
IPR036188, FAD/NAD-bd_sf
IPR029939, MICAL2
IPR001781, Znf_LIM
PANTHERiPTHR23167:SF39, PTHR23167:SF39, 1 hit
PfamiView protein in Pfam
PF00307, CH, 1 hit
PF01494, FAD_binding_3, 1 hit
PF00412, LIM, 1 hit
SMARTiView protein in SMART
SM00033, CH, 1 hit
SM00132, LIM, 1 hit
SUPFAMiSSF47576, SSF47576, 1 hit
SSF51905, SSF51905, 1 hit
PROSITEiView protein in PROSITE
PS50021, CH, 1 hit
PS00478, LIM_DOMAIN_1, 1 hit
PS50023, LIM_DOMAIN_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH9G9P0_ANOCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H9G9P0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 16, 2012
Last sequence update: June 26, 2013
Last modified: September 29, 2021
This is version 62 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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