UniProtKB - H9G9N0 (H9G9N0_ANOCA)
Protein
S-adenosylmethionine synthase
Gene
MAT1A
Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Functioni
Catalyzes the formation of S-adenosylmethionine from methionine and ATP.UniRule annotation
Catalytic activityi
- ATP + H2O + L-methionine = diphosphate + phosphate + S-adenosyl-L-methionineUniRule annotationARBA annotationEC:2.5.1.6UniRule annotationARBA annotation
: S-adenosyl-L-methionine biosynthesis Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes S-adenosyl-L-methionine from L-methionine.UniRule annotationARBA annotationProteins known to be involved in this subpathway in this organism are:
- Methionine adenosyltransferase 2 subunit beta (MAT2B), S-adenosylmethionine synthase (MAT1A), S-adenosylmethionine synthase (MAT2A)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes S-adenosyl-L-methionine from L-methionine, the pathway S-adenosyl-L-methionine biosynthesis and in Amino-acid biosynthesis.
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- identical protein binding Source: Ensembl
- metal ion binding Source: UniProtKB-KW
- methionine adenosyltransferase activity Source: GO_Central
GO - Biological processi
- methionine catabolic process Source: Ensembl
- one-carbon metabolic process Source: UniProtKB-KW
- protein homotetramerization Source: Ensembl
- S-adenosylmethionine biosynthetic process Source: GO_Central
Keywordsi
Molecular function | TransferaseUniRule annotationARBA annotation |
Biological process | One-carbon metabolismUniRule annotationARBA annotation |
Ligand | ATP-bindingUniRule annotationARBA annotation, MagnesiumUniRule annotationARBA annotation, Metal-bindingUniRule annotationARBA annotation, Nucleotide-binding, PotassiumUniRule annotationARBA annotation |
Enzyme and pathway databases
UniPathwayi | UPA00315;UER00080 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:MAT1AImported |
Organismi | Anolis carolinensis (Green anole) (American chameleon)Imported |
Taxonomic identifieri | 28377 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Iguania › Dactyloidae › Anolis |
Proteomesi |
|
Subcellular locationi
Cytosol
- cytosol Source: GO_Central
Expressioni
Gene expression databases
Bgeei | ENSACAG00000004911, Expressed in kidney and 15 other tissues |
Interactioni
GO - Molecular functioni
- identical protein binding Source: Ensembl
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000004790 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 20 – 117 | S-AdoMet_synt_NInterPro annotationAdd BLAST | 98 | |
Domaini | 131 – 252 | S-AdoMet_synt_MInterPro annotationAdd BLAST | 122 | |
Domaini | 254 – 390 | S-AdoMet_synt_CInterPro annotationAdd BLAST | 137 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1506, Eukaryota |
GeneTreei | ENSGT00950000183185 |
HOGENOMi | CLU_041802_0_1_1 |
InParanoidi | H9G9N0 |
OrthoDBi | 685006at2759 |
TreeFami | TF300511 |
Family and domain databases
HAMAPi | MF_00086, S_AdoMet_synth1, 1 hit |
InterProi | View protein in InterPro IPR022631, ADOMET_SYNTHASE_CS IPR022630, S-AdoMet_synt_C IPR022629, S-AdoMet_synt_central IPR022628, S-AdoMet_synt_N IPR002133, S-AdoMet_synthetase IPR022636, S-AdoMet_synthetase_sfam |
PANTHERi | PTHR11964, PTHR11964, 1 hit |
Pfami | View protein in Pfam PF02773, S-AdoMet_synt_C, 1 hit PF02772, S-AdoMet_synt_M, 1 hit PF00438, S-AdoMet_synt_N, 1 hit |
PIRSFi | PIRSF000497, MAT, 1 hit |
SUPFAMi | SSF55973, SSF55973, 3 hits |
TIGRFAMsi | TIGR01034, metK, 1 hit |
PROSITEi | View protein in PROSITE PS00376, ADOMET_SYNTHASE_1, 1 hit PS00377, ADOMET_SYNTHASE_2, 1 hit |
i Sequence
Sequence statusi: Complete.
H9G9N0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNGTLDSLED YTFNEEAGAF MFTSESVGEG HPDKICDQIS DAVLDAHLKQ
60 70 80 90 100
DPNAKVACET VCKTGMVLLC GEITSTAVVD YQQIVRDTIM NIGYDDSSKG
110 120 130 140 150
FDYKTCNVLV ALEQQSPDIA QGVHLHRSEE EVGAGDQGLM FGYATDETEE
160 170 180 190 200
CMPLTIMLAH KLNAKMAELR RNGILPWLRP DSKTQITVQY VKKDGVAIPL
210 220 230 240 250
RVHTIVISAQ HDETISLDAM RKALREHVIK AVVPPRYLDD KTVYHLQPSG
260 270 280 290 300
RFVIGGPQGD AGVTGRKIIV DTYGGWGAHG GGAFSGKDYT KVDRSAAYAA
310 320 330 340 350
RWVAKSLVKA GLCRRVLVQV AYAIGVAEPL SVSLFTYGTS TRTEQELLNI
360 370 380 390
VHQNFDLRPG AIVKDLDLKK PIYQKTACYG HFGRSEFSWE VPKKLAF
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAWZ02021077 Genomic DNA No translation available. AAWZ02021078 Genomic DNA No translation available. AAWZ02021079 Genomic DNA No translation available. AAWZ02021080 Genomic DNA No translation available. |
RefSeqi | XP_008114004.1, XM_008115797.2 |
Genome annotation databases
Ensembli | ENSACAT00000004898; ENSACAP00000004790; ENSACAG00000004911 |
GeneIDi | 100559997 |
KEGGi | acs:100559997 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAWZ02021077 Genomic DNA No translation available. AAWZ02021078 Genomic DNA No translation available. AAWZ02021079 Genomic DNA No translation available. AAWZ02021080 Genomic DNA No translation available. |
RefSeqi | XP_008114004.1, XM_008115797.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000004790 |
Genome annotation databases
Ensembli | ENSACAT00000004898; ENSACAP00000004790; ENSACAG00000004911 |
GeneIDi | 100559997 |
KEGGi | acs:100559997 |
Organism-specific databases
CTDi | 4143 |
Phylogenomic databases
eggNOGi | KOG1506, Eukaryota |
GeneTreei | ENSGT00950000183185 |
HOGENOMi | CLU_041802_0_1_1 |
InParanoidi | H9G9N0 |
OrthoDBi | 685006at2759 |
TreeFami | TF300511 |
Enzyme and pathway databases
UniPathwayi | UPA00315;UER00080 |
Gene expression databases
Bgeei | ENSACAG00000004911, Expressed in kidney and 15 other tissues |
Family and domain databases
HAMAPi | MF_00086, S_AdoMet_synth1, 1 hit |
InterProi | View protein in InterPro IPR022631, ADOMET_SYNTHASE_CS IPR022630, S-AdoMet_synt_C IPR022629, S-AdoMet_synt_central IPR022628, S-AdoMet_synt_N IPR002133, S-AdoMet_synthetase IPR022636, S-AdoMet_synthetase_sfam |
PANTHERi | PTHR11964, PTHR11964, 1 hit |
Pfami | View protein in Pfam PF02773, S-AdoMet_synt_C, 1 hit PF02772, S-AdoMet_synt_M, 1 hit PF00438, S-AdoMet_synt_N, 1 hit |
PIRSFi | PIRSF000497, MAT, 1 hit |
SUPFAMi | SSF55973, SSF55973, 3 hits |
TIGRFAMsi | TIGR01034, metK, 1 hit |
PROSITEi | View protein in PROSITE PS00376, ADOMET_SYNTHASE_1, 1 hit PS00377, ADOMET_SYNTHASE_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | H9G9N0_ANOCA | |
Accessioni | H9G9N0Primary (citable) accession number: H9G9N0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 16, 2012 |
Last sequence update: | June 26, 2013 | |
Last modified: | December 2, 2020 | |
This is version 50 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |