UniProtKB - H9G9J1 (H9G9J1_ANOCA)
Protein
PTH/PTHrP type I receptor
Gene
pth1r
Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Functioni
GO - Molecular functioni
- G protein-coupled peptide receptor activity Source: GO_Central
- parathyroid hormone receptor activity Source: GO_Central
- peptide hormone binding Source: GO_Central
GO - Biological processi
- adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: GO_Central
- adenylate cyclase-modulating G protein-coupled receptor signaling pathway Source: GO_Central
- cell surface receptor signaling pathway Source: InterPro
- cellular calcium ion homeostasis Source: GO_Central
Keywordsi
Molecular function | G-protein coupled receptorARBA annotation, Receptor, Transducer |
Names & Taxonomyi
Protein namesi | Recommended name: PTH/PTHrP type I receptorARBA annotationAlternative name(s): Parathyroid hormone 1 receptorARBA annotation Parathyroid hormone/parathyroid hormone-related peptide receptorARBA annotation |
Gene namesi | Name:pth1rImported |
Organismi | Anolis carolinensis (Green anole) (American chameleon)Imported |
Taxonomic identifieri | 28377 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Iguania › Dactyloidae › Anolis |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 81 – 102 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 215 – 236 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 301 – 321 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 341 – 361 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | ENSACAG00000004743, Expressed in kidney and 13 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 67 | G_PROTEIN_RECEP_F2_3InterPro annotationAdd BLAST | 67 | |
Domaini | 80 – 358 | G_PROTEIN_RECEP_F2_4InterPro annotationAdd BLAST | 279 |
Sequence similaritiesi
Belongs to the G-protein coupled receptor 2 family.ARBA annotation
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
eggNOGi | KOG4564, Eukaryota |
GeneTreei | ENSGT00940000158574 |
HOGENOMi | CLU_002753_4_3_1 |
InParanoidi | H9G9J1 |
OMAi | SGTLWQI |
TreeFami | TF315710 |
Family and domain databases
Gene3Di | 4.10.1240.10, 1 hit |
InterProi | View protein in InterPro IPR017981, GPCR_2-like IPR036445, GPCR_2_extracell_dom_sf IPR001879, GPCR_2_extracellular_dom IPR002170, GPCR_2_parathyroid_rcpt IPR000832, GPCR_2_secretin-like IPR017983, GPCR_2_secretin-like_CS |
PANTHERi | PTHR45620:SF27, PTHR45620:SF27, 1 hit |
Pfami | View protein in Pfam PF00002, 7tm_2, 1 hit PF02793, HRM, 1 hit |
PRINTSi | PR00249, GPCRSECRETIN PR00393, PTRHORMONER |
SMARTi | View protein in SMART SM00008, HormR, 1 hit |
SUPFAMi | SSF111418, SSF111418, 1 hit |
PROSITEi | View protein in PROSITE PS00649, G_PROTEIN_RECEP_F2_1, 1 hit PS00650, G_PROTEIN_RECEP_F2_2, 1 hit PS50227, G_PROTEIN_RECEP_F2_3, 1 hit PS50261, G_PROTEIN_RECEP_F2_4, 1 hit |
i Sequence
Sequence statusi: Complete.
H9G9J1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
CVPEWDTLIC WPESAPGTLV SMPCPDYIFD FNHKGHAHRQ CDRNGSWVQV
60 70 80 90 100
PSVNLTWANY SECAKFFPID TRQKEIFHRL YVIYTVGYSI SLTSLTIAVL
110 120 130 140 150
ILGYFRRLHC TRNYIHMHLF VSFMLRAISI FVKDAVLYSG SALEETERIS
160 170 180 190 200
EEDFKSITEA PPADKSSLAL LKYVGCKVAV TLFLYFLATN YYWILVEGLY
210 220 230 240 250
LHSLIFMAFF SEKKYLWGLT FFGWGLPAVF VLVWATLRAT VADTECWDLS
260 270 280 290 300
AGYFKWFIQV PILQDIQANF ILFIKIIRVL ATKLRETNAG RCDTRQQYRK
310 320 330 340 350
LLKSTLVLMP LFGVHYIVFM AMPYTEVSGI LWQIQMHYEM LFNSFQGFFV
360 370 380 390 400
AIIYCFCNGE VQAEIKKSWS RWTLALDFKR KARSGSTTYS YGPMVSHTSI
410 420 430 440 450
TNVTTRGGGS IALHLNTRLL PGSVNGHRNL PGYVKNGSIS ENSLPSSGPE
460 470 480
QYNKDEEYLN GSGLYNGDKP TILVEEECQD TI
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAWZ02031894 Genomic DNA No translation available. AAWZ02031895 Genomic DNA No translation available. AAWZ02031896 Genomic DNA No translation available. AAWZ02031897 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENSACAT00000004814; ENSACAP00000004707; ENSACAG00000004743 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAWZ02031894 Genomic DNA No translation available. AAWZ02031895 Genomic DNA No translation available. AAWZ02031896 Genomic DNA No translation available. AAWZ02031897 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000004707 |
Protein family/group databases
GPCRDBi | Search... |
Genome annotation databases
Ensembli | ENSACAT00000004814; ENSACAP00000004707; ENSACAG00000004743 |
Phylogenomic databases
eggNOGi | KOG4564, Eukaryota |
GeneTreei | ENSGT00940000158574 |
HOGENOMi | CLU_002753_4_3_1 |
InParanoidi | H9G9J1 |
OMAi | SGTLWQI |
TreeFami | TF315710 |
Gene expression databases
Bgeei | ENSACAG00000004743, Expressed in kidney and 13 other tissues |
Family and domain databases
Gene3Di | 4.10.1240.10, 1 hit |
InterProi | View protein in InterPro IPR017981, GPCR_2-like IPR036445, GPCR_2_extracell_dom_sf IPR001879, GPCR_2_extracellular_dom IPR002170, GPCR_2_parathyroid_rcpt IPR000832, GPCR_2_secretin-like IPR017983, GPCR_2_secretin-like_CS |
PANTHERi | PTHR45620:SF27, PTHR45620:SF27, 1 hit |
Pfami | View protein in Pfam PF00002, 7tm_2, 1 hit PF02793, HRM, 1 hit |
PRINTSi | PR00249, GPCRSECRETIN PR00393, PTRHORMONER |
SMARTi | View protein in SMART SM00008, HormR, 1 hit |
SUPFAMi | SSF111418, SSF111418, 1 hit |
PROSITEi | View protein in PROSITE PS00649, G_PROTEIN_RECEP_F2_1, 1 hit PS00650, G_PROTEIN_RECEP_F2_2, 1 hit PS50227, G_PROTEIN_RECEP_F2_3, 1 hit PS50261, G_PROTEIN_RECEP_F2_4, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | H9G9J1_ANOCA | |
Accessioni | H9G9J1Primary (citable) accession number: H9G9J1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 16, 2012 |
Last sequence update: | May 16, 2012 | |
Last modified: | December 2, 2020 | |
This is version 56 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |