UniProtKB - H9G8Y1 (H9G8Y1_ANOCA)
Protein
Neuropilin
Gene
NRP2
Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Functioni
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 199 | CalciumUniRule annotation | 1 | |
Metal bindingi | 213 | CalciumUniRule annotation | 1 | |
Metal bindingi | 254 | CalciumUniRule annotation | 1 |
GO - Molecular functioni
- heparin binding Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-UniRule
- semaphorin receptor activity Source: Ensembl
- vascular endothelial growth factor-activated receptor activity Source: InterPro
GO - Biological processi
- angiogenesis Source: InterPro
- axon extension involved in axon guidance Source: Ensembl
- cellular response to leukemia inhibitory factor Source: Ensembl
- dorsal root ganglion morphogenesis Source: Ensembl
- facial nerve structural organization Source: Ensembl
- facioacoustic ganglion development Source: Ensembl
- gonadotrophin-releasing hormone neuronal migration to the hypothalamus Source: Ensembl
- negative chemotaxis Source: Ensembl
- neural crest cell migration involved in autonomic nervous system development Source: Ensembl
- outflow tract septum morphogenesis Source: Ensembl
- regulation of postsynapse organization Source: Ensembl
- semaphorin-plexin signaling pathway involved in neuron projection guidance Source: Ensembl
- sensory neuron axon guidance Source: Ensembl
- sympathetic ganglion development Source: Ensembl
- sympathetic neuron projection extension Source: Ensembl
- sympathetic neuron projection guidance Source: Ensembl
- trigeminal ganglion development Source: Ensembl
- ventral trunk neural crest cell migration Source: Ensembl
- vestibulocochlear nerve structural organization Source: Ensembl
Keywordsi
Molecular function | Developmental proteinUniRule annotation, Heparin-bindingARBA annotation, ReceptorUniRule annotation |
Biological process | DifferentiationUniRule annotationARBA annotation, NeurogenesisUniRule annotationARBA annotation |
Ligand | CalciumUniRule annotation, Metal-bindingUniRule annotation |
Names & Taxonomyi
Protein namesi | Recommended name: NeuropilinUniRule annotation |
Gene namesi | Name:NRP2Imported |
Organismi | Anolis carolinensis (Green anole) (American chameleon)Imported |
Taxonomic identifieri | 28377 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Iguania › Dactyloidae › Anolis |
Proteomesi |
|
Subcellular locationi
Plasma Membrane
- integral component of postsynaptic membrane Source: Ensembl
Other locations
- axon Source: Ensembl
- glutamatergic synapse Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 880 – 905 | HelicalSequence analysisAdd BLAST | 26 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 23 | Sequence analysisAdd BLAST | 23 | |
ChainiPRO_5003620939 | 24 – 946 | NeuropilinSequence analysisAdd BLAST | 923 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 30 ↔ 57 | UniRule annotation | ||
Disulfide bondi | 85 ↔ 107 | UniRule annotation | ||
Disulfide bondi | 151 ↔ 177 | UniRule annotation | ||
Disulfide bondi | 210 ↔ 232 | UniRule annotation | ||
Disulfide bondi | 279 ↔ 429 | UniRule annotation | ||
Disulfide bondi | 436 ↔ 594 | UniRule annotation |
Keywords - PTMi
Disulfide bondUniRule annotationARBA annotationExpressioni
Gene expression databases
Bgeei | ENSACAG00000004128, Expressed in embryonic post-anal tail and 14 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 30 – 144 | CUBInterPro annotationAdd BLAST | 115 | |
Domaini | 151 – 269 | CUBInterPro annotationAdd BLAST | 119 | |
Domaini | 279 – 429 | F5/8 type CInterPro annotationAdd BLAST | 151 | |
Domaini | 436 – 594 | F5/8 type CInterPro annotationAdd BLAST | 159 | |
Domaini | 644 – 808 | MAMInterPro annotationAdd BLAST | 165 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 298 – 321 | DisorderedSequence analysisAdd BLAST | 24 |
Sequence similaritiesi
Keywords - Domaini
SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
eggNOGi | ENOG502QVB7, Eukaryota |
GeneTreei | ENSGT00940000155270 |
HOGENOMi | CLU_015228_6_1_1 |
InParanoidi | H9G8Y1 |
OrthoDBi | 124611at2759 |
Family and domain databases
CDDi | cd00041, CUB, 2 hits cd00057, FA58C, 2 hits cd06263, MAM, 1 hit |
Gene3Di | 2.60.120.260, 2 hits 2.60.120.290, 2 hits |
InterProi | View protein in InterPro IPR013320, ConA-like_dom_sf IPR000859, CUB_dom IPR000421, FA58C IPR008979, Galactose-bd-like_sf IPR000998, MAM_dom IPR014648, Neuropilin IPR027143, Neuropilin-2 IPR022579, Neuropilin_C IPR035914, Sperma_CUB_dom_sf |
PANTHERi | PTHR46806:SF2, PTHR46806:SF2, 1 hit |
Pfami | View protein in Pfam PF00431, CUB, 2 hits PF11980, DUF3481, 1 hit PF00754, F5_F8_type_C, 2 hits PF00629, MAM, 1 hit |
PIRSFi | PIRSF036960, Neuropilin, 1 hit |
PRINTSi | PR00020, MAMDOMAIN |
SMARTi | View protein in SMART SM00042, CUB, 2 hits SM00231, FA58C, 2 hits SM00137, MAM, 1 hit |
SUPFAMi | SSF49785, SSF49785, 2 hits SSF49854, SSF49854, 2 hits SSF49899, SSF49899, 1 hit |
PROSITEi | View protein in PROSITE PS01180, CUB, 2 hits PS01285, FA58C_1, 2 hits PS01286, FA58C_2, 2 hits PS50022, FA58C_3, 2 hits PS50060, MAM_2, 1 hit |
i Sequence
Sequence statusi: Complete.
H9G8Y1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDTFAFLWRS LLIFFWAGSG VRAQAAAQSC GGRLNSKDAG YITSPGYPHD
60 70 80 90 100
YPSHQNCEWI IYAPEPNQKI ILNFNPHFEI EKHDCKYDFI EIRDGDSESA
110 120 130 140 150
DLLGKHCGNI APPTITSTGP SLYIKFTSDY ARQGAGFSLR YEIYKTGSED
160 170 180 190 200
CSRNFTGSNG TIESPGFPDK YPHNLDCAFT IMAKPKMEII LQFLTFDLEH
210 220 230 240 250
DPLQVGEGDC KYDWLDIWDG IPQVGPLIGR YCGTKTPSEI RSTTGILSLT
260 270 280 290 300
FHTDLAVAKD GFSARYYLVQ QEVPENFQCN SPLGMESGRI SNEQITASST
310 320 330 340 350
YSDGRWTPQQ SRLNSDDNGW TPNVDSNKEF LQVDLRFLTM LTAIATQGAI
360 370 380 390 400
SRETQTGYYV RTYKLEVSTN GEDWMMYRHG KNHKVFQANT DASEVVLNKI
410 420 430 440 450
HSPVLTRFVR IRPQNWHSGI ALRLELYGCR ITDSPCSNML GMLSGLIPDS
460 470 480 490 500
QISASSTREY HWVPSVARLV SSRSGWFPRI PQAQPGEEWL QVDLGVPKNV
510 520 530 540 550
KGVIIQGARG GDTSSAVEAR AFVKRFKVAY SMNGKDWEYI QDLKTMQAKI
560 570 580 590 600
FEGNMHYDTP EVRRFDPVPA QFVRVHPERW SPAGIGMRLE VLGCDWMEVK
610 620 630 640 650
STAETLKPTL KSEEITTHFP TDEEATDCGD GCVENGDFQI PIGFNCNFDL
660 670 680 690 700
PGDLCGWTPD TSAGSTWTFH SRNPWTSHSG PGIEAYPDGK TYLRLQSSAR
710 720 730 740 750
REGQHARLVS PAVFLPRSAV CMIFRYQVSG GSGTMLQVRR EATHENKALW
760 770 780 790 800
IIREDQGEEW REGRILLSSY EMEYQIVFEG IISKGHSGEI AINDVRIGTD
810 820 830 840 850
TSLENCMEPI AAFPGEHTYE IPVDFPALES DITIHGEEFG DDNEDDYLGL
860 870 880 890 900
SRNNTLFSTN SPLTPKVDKE KSWLYTLDPI LVTIITMSSL GVLLGAICAG
910 920 930 940
LLLYCTCSYA GLSSRSSTTL ENYNFELYDG IKHKVKMNHQ KCCSEA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAWZ02015254 Genomic DNA No translation available. AAWZ02015255 Genomic DNA No translation available. AAWZ02015256 Genomic DNA No translation available. AAWZ02015257 Genomic DNA No translation available. AAWZ02015258 Genomic DNA No translation available. AAWZ02015259 Genomic DNA No translation available. |
RefSeqi | XP_008113148.1, XM_008114941.2 |
Genome annotation databases
Ensembli | ENSACAT00000004369; ENSACAP00000004269; ENSACAG00000004128 |
GeneIDi | 100552730 |
KEGGi | acs:100552730 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAWZ02015254 Genomic DNA No translation available. AAWZ02015255 Genomic DNA No translation available. AAWZ02015256 Genomic DNA No translation available. AAWZ02015257 Genomic DNA No translation available. AAWZ02015258 Genomic DNA No translation available. AAWZ02015259 Genomic DNA No translation available. |
RefSeqi | XP_008113148.1, XM_008114941.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000004269 |
Genome annotation databases
Ensembli | ENSACAT00000004369; ENSACAP00000004269; ENSACAG00000004128 |
GeneIDi | 100552730 |
KEGGi | acs:100552730 |
Organism-specific databases
CTDi | 8828 |
Phylogenomic databases
eggNOGi | ENOG502QVB7, Eukaryota |
GeneTreei | ENSGT00940000155270 |
HOGENOMi | CLU_015228_6_1_1 |
InParanoidi | H9G8Y1 |
OrthoDBi | 124611at2759 |
Gene expression databases
Bgeei | ENSACAG00000004128, Expressed in embryonic post-anal tail and 14 other tissues |
Family and domain databases
CDDi | cd00041, CUB, 2 hits cd00057, FA58C, 2 hits cd06263, MAM, 1 hit |
Gene3Di | 2.60.120.260, 2 hits 2.60.120.290, 2 hits |
InterProi | View protein in InterPro IPR013320, ConA-like_dom_sf IPR000859, CUB_dom IPR000421, FA58C IPR008979, Galactose-bd-like_sf IPR000998, MAM_dom IPR014648, Neuropilin IPR027143, Neuropilin-2 IPR022579, Neuropilin_C IPR035914, Sperma_CUB_dom_sf |
PANTHERi | PTHR46806:SF2, PTHR46806:SF2, 1 hit |
Pfami | View protein in Pfam PF00431, CUB, 2 hits PF11980, DUF3481, 1 hit PF00754, F5_F8_type_C, 2 hits PF00629, MAM, 1 hit |
PIRSFi | PIRSF036960, Neuropilin, 1 hit |
PRINTSi | PR00020, MAMDOMAIN |
SMARTi | View protein in SMART SM00042, CUB, 2 hits SM00231, FA58C, 2 hits SM00137, MAM, 1 hit |
SUPFAMi | SSF49785, SSF49785, 2 hits SSF49854, SSF49854, 2 hits SSF49899, SSF49899, 1 hit |
PROSITEi | View protein in PROSITE PS01180, CUB, 2 hits PS01285, FA58C_1, 2 hits PS01286, FA58C_2, 2 hits PS50022, FA58C_3, 2 hits PS50060, MAM_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | H9G8Y1_ANOCA | |
Accessioni | H9G8Y1Primary (citable) accession number: H9G8Y1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 16, 2012 |
Last sequence update: | June 26, 2013 | |
Last modified: | February 10, 2021 | |
This is version 61 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |