UniProtKB - H9G8L4 (H9G8L4_ANOCA)
Protein
Procollagen-lysine 5-dioxygenase
Gene
PLOD3
Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Functioni
Catalytic activityi
- 2-oxoglutarate + L-lysyl-[procollagen] + O2 = (5R)-5-hydroxy-L-lysyl-[procollagen] + CO2 + succinateARBA annotationEC:1.14.11.4ARBA annotation
Cofactori
Protein has several cofactor binding sites:- Fe2+ARBA annotation
- L-ascorbateARBA annotation
GO - Molecular functioni
- iron ion binding Source: InterPro
- L-ascorbic acid binding Source: UniProtKB-KW
- procollagen galactosyltransferase activity Source: Ensembl
- procollagen glucosyltransferase activity Source: GO_Central
- procollagen-lysine 5-dioxygenase activity Source: GO_Central
GO - Biological processi
- peptidyl-lysine hydroxylation Source: GO_Central
- protein O-linked glycosylation Source: Ensembl
Keywordsi
Molecular function | DioxygenaseARBA annotation, Oxidoreductase |
Ligand | IronARBA annotation, Metal-bindingARBA annotation, Vitamin CARBA annotation |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:PLOD3Imported |
Organismi | Anolis carolinensis (Green anole) (American chameleon)Imported |
Taxonomic identifieri | 28377 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Iguania › Dactyloidae › Anolis |
Proteomesi |
|
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane ARBA annotation; Peripheral membrane protein ARBA annotation; Lumenal side ARBA annotation
Endoplasmic reticulum
- endoplasmic reticulum Source: GO_Central
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Golgi apparatus
- Golgi apparatus Source: Ensembl
Keywords - Cellular componenti
MembraneARBA annotationPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 23 | Sequence analysisAdd BLAST | 23 | |
ChainiPRO_5003620923 | 24 – 738 | Procollagen-lysine 5-dioxygenaseSequence analysisAdd BLAST | 715 |
Expressioni
Gene expression databases
Bgeei | ENSACAG00000003968, Expressed in hemipenis and 14 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 647 – 738 | Fe2OG dioxygenaseInterPro annotationAdd BLAST | 92 |
Keywords - Domaini
SignalSequence analysisARBA annotationPhylogenomic databases
eggNOGi | KOG1971, Eukaryota |
GeneTreei | ENSGT00990000203644 |
HOGENOMi | CLU_022320_1_0_1 |
InParanoidi | H9G8L4 |
OrthoDBi | 194164at2759 |
TreeFami | TF313826 |
Family and domain databases
InterProi | View protein in InterPro IPR029044, Nucleotide-diphossugar_trans IPR005123, Oxoglu/Fe-dep_dioxygenase IPR006620, Pro_4_hyd_alph IPR001006, Procol_lys_dOase |
Pfami | View protein in Pfam PF03171, 2OG-FeII_Oxy, 1 hit |
SMARTi | View protein in SMART SM00702, P4Hc, 1 hit |
SUPFAMi | SSF53448, SSF53448, 1 hit |
PROSITEi | View protein in PROSITE PS51471, FE2OG_OXY, 1 hit PS01325, LYS_HYDROXYLASE, 1 hit |
i Sequence
Sequence statusi: Complete.
H9G8L4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MARPWSAPAV LALWMMGVAV AAAAPDEEDP NPVDPGKLLV LTAATDETEG
60 70 80 90 100
YQRFLRTAKF FNYTVKTLGL GEDWKGGDVA RTVGGGQKVR WLKNEMKKYA
110 120 130 140 150
NEEDLIVMFV DSYDVILAGS PIELLWKFRH FKSKLVFSAE SFCWPEWSLA
160 170 180 190 200
EKYPAVAVGK RFLNSGGFIG YAPTINRIVQ MWKYKDNDDD QLFYTRIYLD
210 220 230 240 250
PGLREKHGIT LDHKSKIFQN LNGAIEEVVL KFEPTRVRAR NVAYDTLPVV
260 270 280 290 300
IHGNGPTKLQ LNYLGNYVPN AWTYEGGCGT CDQGLLDLSD LPDESYPRVL
310 320 330 340 350
VGVFIEQPTP FFPQFLQRLL TFDYPYSHLS LFIHNRVVYH EQHIQAEWEQ
360 370 380 390 400
LREAFDSIKL VGPEEDISEG EARDIAMDLC RQDTTCDYYF SLDADVVVTN
410 420 430 440 450
PEILQILIQE NKKVIAPMMS RHGKLWSNFW GALSPDEYYA RSEDYVELVQ
460 470 480 490 500
GKRIGMWNVP YISQAYLLRG ETLRQELPQR NIFTLDDTDP DMAFCKSVRE
510 520 530 540 550
KGIFLHISNR DEFGRLLSTS RYNTSRLHPD LWQISENPLD WQDKYIHENY
560 570 580 590 600
SRVLEGEYHE QPCPDVYWFP VFTDQMCDEL VEEAENFGQW SGGKHEDTRL
610 620 630 640 650
AGGYENVPTV DIHMNQISFE KEWLQFLRDY IAPVTEKLYP GYYTKARAIM
660 670 680 690 700
NFMVRYRPDE QPSLRPHHDS STFTINVALN HKGIDYEGGG CRFIRYNCQV
710 720 730
ESPRKGWSLM HPGRLTHYHE GLPTTSGTRY IMVSFVDP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAWZ02028496 Genomic DNA No translation available. AAWZ02028497 Genomic DNA No translation available. |
RefSeqi | XP_008118590.1, XM_008120383.2 |
Genome annotation databases
Ensembli | ENSACAT00000004154; ENSACAP00000004060; ENSACAG00000003968 |
GeneIDi | 100558042 |
KEGGi | acs:100558042 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAWZ02028496 Genomic DNA No translation available. AAWZ02028497 Genomic DNA No translation available. |
RefSeqi | XP_008118590.1, XM_008120383.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000004060 |
Genome annotation databases
Ensembli | ENSACAT00000004154; ENSACAP00000004060; ENSACAG00000003968 |
GeneIDi | 100558042 |
KEGGi | acs:100558042 |
Organism-specific databases
CTDi | 8985 |
Phylogenomic databases
eggNOGi | KOG1971, Eukaryota |
GeneTreei | ENSGT00990000203644 |
HOGENOMi | CLU_022320_1_0_1 |
InParanoidi | H9G8L4 |
OrthoDBi | 194164at2759 |
TreeFami | TF313826 |
Gene expression databases
Bgeei | ENSACAG00000003968, Expressed in hemipenis and 14 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR029044, Nucleotide-diphossugar_trans IPR005123, Oxoglu/Fe-dep_dioxygenase IPR006620, Pro_4_hyd_alph IPR001006, Procol_lys_dOase |
Pfami | View protein in Pfam PF03171, 2OG-FeII_Oxy, 1 hit |
SMARTi | View protein in SMART SM00702, P4Hc, 1 hit |
SUPFAMi | SSF53448, SSF53448, 1 hit |
PROSITEi | View protein in PROSITE PS51471, FE2OG_OXY, 1 hit PS01325, LYS_HYDROXYLASE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | H9G8L4_ANOCA | |
Accessioni | H9G8L4Primary (citable) accession number: H9G8L4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 16, 2012 |
Last sequence update: | June 26, 2013 | |
Last modified: | December 2, 2020 | |
This is version 48 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |