UniProtKB - H9G8E2 (H9G8E2_ANOCA)
Protein
SH3 domain-containing protein
Gene
CTTN
Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Functioni
GO - Molecular functioni
- actin filament binding Source: GO_Central
- profilin binding Source: Ensembl
GO - Biological processi
- actin filament polymerization Source: InterPro
- dendritic spine maintenance Source: Ensembl
- intracellular protein transport Source: Ensembl
- negative regulation of extrinsic apoptotic signaling pathway Source: Ensembl
- positive regulation of actin filament polymerization Source: Ensembl
- positive regulation of smooth muscle contraction Source: Ensembl
- regulation of actin filament polymerization Source: GO_Central
- regulation of autophagy of mitochondrion Source: Ensembl
- substrate-dependent cell migration, cell extension Source: Ensembl
Names & Taxonomyi
Protein namesi | Recommended name: SH3 domain-containing proteinInterPro annotation |
Gene namesi | Name:CTTNImported |
Organismi | Anolis carolinensis (Green anole) (American chameleon)Imported |
Taxonomic identifieri | 28377 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Iguania › Dactyloidae › Anolis |
Proteomesi |
|
Subcellular locationi
Cytoskeleton
- actin filament Source: Ensembl
- cortical actin cytoskeleton Source: GO_Central
- mitotic spindle midzone Source: Ensembl
- podosome Source: Ensembl
Cytosol
- cytosol Source: Ensembl
Golgi apparatus
- Golgi apparatus Source: Ensembl
Plasma Membrane
- plasma membrane Source: GO_Central
- voltage-gated potassium channel complex Source: Ensembl
Other locations
- lamellipodium Source: GO_Central
- ruffle Source: Ensembl
- site of polarized growth Source: GO_Central
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 17 | Sequence analysisAdd BLAST | 17 | |
ChainiPRO_5003619736 | 18 – 569 | SH3 domain-containing proteinSequence analysisAdd BLAST | 552 |
Keywords - PTMi
PhosphoproteinARBA annotationExpressioni
Gene expression databases
Bgeei | ENSACAG00000003923, Expressed in forelimb bud and 14 other tissues |
Interactioni
GO - Molecular functioni
- actin filament binding Source: GO_Central
- profilin binding Source: Ensembl
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000003922 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 511 – 569 | SH3InterPro annotationAdd BLAST | 59 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 371 – 471 | DisorderedSequence analysisAdd BLAST | 101 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 371 – 409 | PolyampholyteSequence analysisAdd BLAST | 39 | |
Compositional biasi | 415 – 431 | Pro-richSequence analysisAdd BLAST | 17 | |
Compositional biasi | 448 – 462 | PolarSequence analysisAdd BLAST | 15 |
Keywords - Domaini
SH3 domainPROSITE-ProRule annotationARBA annotation, SignalSequence analysisPhylogenomic databases
eggNOGi | ENOG502QS6C, Eukaryota |
GeneTreei | ENSGT00940000158565 |
HOGENOMi | CLU_019379_1_0_1 |
InParanoidi | H9G8E2 |
OMAi | FNQMQSP |
TreeFami | TF318935 |
Family and domain databases
CDDi | cd11959, SH3_Cortactin, 1 hit |
InterProi | View protein in InterPro IPR015503, Cortactin IPR035716, Cortactin_SH3 IPR003134, Hs1_Cortactin IPR036028, SH3-like_dom_sf IPR001452, SH3_domain |
PANTHERi | PTHR10829:SF15, PTHR10829:SF15, 4 hits |
Pfami | View protein in Pfam PF02218, HS1_rep, 7 hits PF14604, SH3_9, 1 hit |
PRINTSi | PR00452, SH3DOMAIN |
SMARTi | View protein in SMART SM00326, SH3, 1 hit |
SUPFAMi | SSF50044, SSF50044, 1 hit |
PROSITEi | View protein in PROSITE PS51090, CORTACTIN, 7 hits PS50002, SH3, 1 hit |
i Sequence
Sequence statusi: Complete.
H9G8E2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
PILMFVLIFQ MWKATAGHSI SVNQDDGADD WETDPDFVND VSEKEQRWGA
60 70 80 90 100
KTVQGSGHQE HIKSIHKLRE NVFQEHQTLK EKELQTGPKA SHGYGGKFGV
110 120 130 140 150
EQDRMDKSAV GHEYQSKLSQ HCSQVDSVKG FGGKFGVQVD RVDQSAVGFE
160 170 180 190 200
YQGKTEKHAS QRDYSSGFGG KYGVQADRVD KSAVGFDYQG KTEKHESQKD
210 220 230 240 250
YSRGFGGKYG VDKEKVDKSA VGFEYQAKPE KHESQKDYTK GFGGKFGVQT
260 270 280 290 300
DRQDKCALGW DHQEKVQLHE SQKDYKSGFG GKFGVQTERQ DPSAMGFDYK
310 320 330 340 350
EKLAKHESQK DYSKGFGGKY GVQKDRMDKN ASSFEDIEKL SSTYQKTKPV
360 370 380 390 400
EAANTKTSNI RANFENLAKE KELEDRKKAE AERAQRMAKD KEEQEEARRT
410 420 430 440 450
LEKEAKAKEQ IPPQSPAPQL APQPVPQPVE EKLPSSPVYE DAVSIESEYK
460 470 480 490 500
NSDTNYSTVH EPETNNKAEE SDYQEAVSQR EPEFESEAVY EVAGEGNQYQ
510 520 530 540 550
AGENTYDYEN DLGITAIALY DYQAAGDDEI SFDPDDIITN IEMIDDGWWR
560
GVCKGRYGLF PANYVELRQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAWZ02023324 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENSACAT00000004014; ENSACAP00000003922; ENSACAG00000003923 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAWZ02023324 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000003922 |
Genome annotation databases
Ensembli | ENSACAT00000004014; ENSACAP00000003922; ENSACAG00000003923 |
Phylogenomic databases
eggNOGi | ENOG502QS6C, Eukaryota |
GeneTreei | ENSGT00940000158565 |
HOGENOMi | CLU_019379_1_0_1 |
InParanoidi | H9G8E2 |
OMAi | FNQMQSP |
TreeFami | TF318935 |
Gene expression databases
Bgeei | ENSACAG00000003923, Expressed in forelimb bud and 14 other tissues |
Family and domain databases
CDDi | cd11959, SH3_Cortactin, 1 hit |
InterProi | View protein in InterPro IPR015503, Cortactin IPR035716, Cortactin_SH3 IPR003134, Hs1_Cortactin IPR036028, SH3-like_dom_sf IPR001452, SH3_domain |
PANTHERi | PTHR10829:SF15, PTHR10829:SF15, 4 hits |
Pfami | View protein in Pfam PF02218, HS1_rep, 7 hits PF14604, SH3_9, 1 hit |
PRINTSi | PR00452, SH3DOMAIN |
SMARTi | View protein in SMART SM00326, SH3, 1 hit |
SUPFAMi | SSF50044, SSF50044, 1 hit |
PROSITEi | View protein in PROSITE PS51090, CORTACTIN, 7 hits PS50002, SH3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | H9G8E2_ANOCA | |
Accessioni | H9G8E2Primary (citable) accession number: H9G8E2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 16, 2012 |
Last sequence update: | May 16, 2012 | |
Last modified: | December 2, 2020 | |
This is version 57 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |