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Entry version 60 (12 Aug 2020)
Sequence version 2 (26 Jun 2013)
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Protein
Submitted name:

Uncharacterized protein

Gene

IQGAP1

Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Unreviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IQGAP1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnolis carolinensis (Green anole) (American chameleon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri28377 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaIguaniaDactyloidaeAnolis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001646 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

PhosphoproteinARBA annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSACAG00000003240, Expressed in lung and 14 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
28377.ENSACAP00000003589

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini306 – 421Calponin-homology (CH)InterPro annotationAdd BLAST116
Domaini944 – 977WWInterPro annotationAdd BLAST34
Domaini1269 – 1502Ras-GAPInterPro annotationAdd BLAST234

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni67 – 98DisorderedSequence analysisAdd BLAST32
Regioni119 – 275DisorderedSequence analysisAdd BLAST157

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili430 – 457Sequence analysisAdd BLAST28
Coiled coili525 – 561Sequence analysisAdd BLAST37
Coiled coili633 – 653Sequence analysisAdd BLAST21
Coiled coili752 – 779Sequence analysisAdd BLAST28
Coiled coili1154 – 1174Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi78 – 98BasicSequence analysisAdd BLAST21
Compositional biasi147 – 161PolyampholyteSequence analysisAdd BLAST15
Compositional biasi244 – 265PolyampholyteSequence analysisAdd BLAST22

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2128, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183076

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000972_2_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
H9G7W7

Database of Orthologous Groups

More...
OrthoDBi
674320at2759

TreeFam database of animal gene trees

More...
TreeFami
TF313078

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00014, CH, 1 hit
cd00201, WW, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.418.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR000048, IQ_motif_EF-hand-BS
IPR027417, P-loop_NTPase
IPR000593, RasGAP_C
IPR023152, RasGAP_CS
IPR001936, RasGAP_dom
IPR008936, Rho_GTPase_activation_prot
IPR001202, WW_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00307, CH, 1 hit
PF00612, IQ, 4 hits
PF00616, RasGAP, 1 hit
PF03836, RasGAP_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00033, CH, 1 hit
SM00015, IQ, 4 hits
SM00323, RasGAP, 1 hit
SM00456, WW, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47576, SSF47576, 1 hit
SSF48350, SSF48350, 1 hit
SSF52540, SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50021, CH, 1 hit
PS50096, IQ, 4 hits
PS00509, RAS_GTPASE_ACTIV_1, 1 hit
PS50018, RAS_GTPASE_ACTIV_2, 1 hit
PS01159, WW_DOMAIN_1, 1 hit
PS50020, WW_DOMAIN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

H9G7W7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLCCNYCIYE FSTKISRYIE NIDYKNGLDN PEPWISESWK SETHTCICKC
60 70 80 90 100
MTPLLARPRP PPLRPGALLM PRGGPVPHLR GRQRRGGRGR RGRGLRRRGR
110 120 130 140 150
GLAGMVVIGG LGEVAEAEVE GAEAEEAPKQ RGPRSGGAAA AAPRETPAGG
160 170 180 190 200
REEEEEARFR SGPLGGEAQG KRGGGVASHL QAPPGHEEPP RVAPQRQQQL
210 220 230 240 250
VDHPGRRGAG LADWAGTSPA HAHDTRAGQL PAAPRQSVSQ SVKAGRKEGR
260 270 280 290 300
ERGRPRRRAR LLPEMSAAEE SEGAARPHYG SVLDNERMTA EEMDERRLQN
310 320 330 340 350
VAYEYLCHLE EAKRWMEACL NEELPPTTEL EEGLRNGVYL AKLGNFFSPK
360 370 380 390 400
VVSLKKIYDR EQTRYKATGL HFRHTDNVIQ WLNAMAEIGL PKIFYPETTD
410 420 430 440 450
IYDRKNMPRC IYCIHALSLY LFKLGLAPQI QDLYGKVDFT EEEISNMRSE
460 470 480 490 500
LDKYGIQMPA FGKIGGILAN ELSVDEAALH AAVIAINDAI ERQVPVDTLA
510 520 530 540 550
AMRNPNAMLV NLEEPLAPVY QETLYRAKQN KMENARNKIA AEDAARERDV
560 570 580 590 600
YEELLTQAEI QGNVNKVNTH SALSKIDLAL DQGDAEALFR ALSSASLGLR
610 620 630 640 650
GLKHEHSDWY LKQLLREREL KQEDGRGGGP LQKEELQAGV ETANGSAQQY
660 670 680 690 700
QQRLAAVRRI NVAIHNGLPE KTVVELMNPE AQLPPVYPFA ADLYQRELAT
710 720 730 740 750
LQQQSPDGKL THPELSVAVE MLSSVALINR ALDAGDVDMI WKQLSSPVTG
760 770 780 790 800
LTNVEDENLQ RYIEELMRLK AEAQAEGTDF ITWNDIQSCV DRVNVVVQEE
810 820 830 840 850
HERILAIGVI NEALDDGDAK KTLQALQIPA AKLEGVTPRV AQHYQDVLLR
860 870 880 890 900
SKREKAQETR DETAVLWLDE IQGGVHQSNR DTDEAQRFSL GILAINEAVD
910 920 930 940 950
EANVGKTLSA LRSADVGLYG VTPECADIYQ QELAEAKRAK LAAGDNGSAW
960 970 980 990 1000
VKHWVKGGYH YYHNLQTKEG GWEEPQGFAQ NNTQLSREDI QSAISSVTAA
1010 1020 1030 1040 1050
YNREQLWVAN ESLIVRLQAS CRGYLVRKEF STRMHFLKKQ LPAITCIQSQ
1060 1070 1080 1090 1100
WRGYKQRKEY QDRLRFLQAH KDEAVKIQAM TRMHQARKRY RDRLQYFRDH
1110 1120 1130 1140 1150
INDIVKIQAF IRANKARDDY KTLINAVDPP MAVVRKFVHL LDQSDQDFQE
1160 1170 1180 1190 1200
ELDLMKLREE VVTLIRSNQQ LENDLNLMDI KIGLLVQNKI TLQDVVSHSK
1210 1220 1230 1240 1250
KLTKKNKEQL SDMMMLNKQR GGLKALSKEK REKLEAYQHL FYLLQTNPTY
1260 1270 1280 1290 1300
LAKLIFQMPQ NKSTKFMDSV IFTLYNYASN QREEYLLLRL FQTALQEEIK
1310 1320 1330 1340 1350
SKVDQLHEIV TGNPTVIKMV VSFNRGARGQ NALRQMLAPA VKEIMEDKSL
1360 1370 1380 1390 1400
NIKTDPVDIY KAWVNQMESQ TGEASKLPYD VTPEQALSHE EVRTRLDVSL
1410 1420 1430 1440 1450
KNMRTVTDKF LLAIISSLEK IPYGMRFIAK VLKDSLHEKF PDASEDELLK
1460 1470 1480 1490 1500
IVGNLLYYRY MNPAIVAPDA FDIIDMSAGG QLTTDQRRNL GSIAKMLQHA
1510 1520 1530 1540 1550
ASNKMFLGDN AHLSIINEYL SQSYQKFRRF FQAACEVPEL QDKFNVDEYS
1560 1570 1580 1590 1600
DLVTLTKPVI YISIGEIINT HTLFLDHQDA IAPEHNDPIH ELLDDLGEVP
1610 1620 1630 1640 1650
SIESLIGEGS GGMNDPGKEM LAKTEISLTL TNKFDVPVDE NAEMDAKTIL
1660 1670 1680 1690 1700
LNTKRLIVDV IRFQPGETLA EILEVPASRE QEAEHQRAMQ RRAIRDARTP
1710 1720 1730 1740 1750
DKMRTPQAAK EDSNLGLQEK KEKIRSGLKK LVELGLAKPQ NGYQDLINDV
1760 1770 1780 1790 1800
AKDIRNQRRY RQRRKAELVK LQQTQSALNS KATFYGEQVD YYKSYIKTCL
1810 1820 1830 1840 1850
DNLASKGKVS KKPREMKGKK SKKISLKYTA ARLHEKGVLL EIEDLQSSQF
1860 1870 1880 1890 1900
KNVIFEIAPT EEVGDFEVKA KFMGVQMETF MLHYQDLLQL QYEGVAVMKL
1910 1920
FDRAKVNVNL LIFLLNKKFY GK
Length:1,922
Mass (Da):217,490
Last modified:June 26, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7BD83D3F8C5C1C6E
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAWZ02033960 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSACAT00000003677; ENSACAP00000003589; ENSACAG00000003240

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAWZ02033960 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi28377.ENSACAP00000003589

Genome annotation databases

EnsembliENSACAT00000003677; ENSACAP00000003589; ENSACAG00000003240

Phylogenomic databases

eggNOGiKOG2128, Eukaryota
GeneTreeiENSGT00950000183076
HOGENOMiCLU_000972_2_1_1
InParanoidiH9G7W7
OrthoDBi674320at2759
TreeFamiTF313078

Gene expression databases

BgeeiENSACAG00000003240, Expressed in lung and 14 other tissues

Family and domain databases

CDDicd00014, CH, 1 hit
cd00201, WW, 1 hit
Gene3Di1.10.418.10, 1 hit
InterProiView protein in InterPro
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR000048, IQ_motif_EF-hand-BS
IPR027417, P-loop_NTPase
IPR000593, RasGAP_C
IPR023152, RasGAP_CS
IPR001936, RasGAP_dom
IPR008936, Rho_GTPase_activation_prot
IPR001202, WW_dom
PfamiView protein in Pfam
PF00307, CH, 1 hit
PF00612, IQ, 4 hits
PF00616, RasGAP, 1 hit
PF03836, RasGAP_C, 1 hit
SMARTiView protein in SMART
SM00033, CH, 1 hit
SM00015, IQ, 4 hits
SM00323, RasGAP, 1 hit
SM00456, WW, 1 hit
SUPFAMiSSF47576, SSF47576, 1 hit
SSF48350, SSF48350, 1 hit
SSF52540, SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50021, CH, 1 hit
PS50096, IQ, 4 hits
PS00509, RAS_GTPASE_ACTIV_1, 1 hit
PS50018, RAS_GTPASE_ACTIV_2, 1 hit
PS01159, WW_DOMAIN_1, 1 hit
PS50020, WW_DOMAIN_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH9G7W7_ANOCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H9G7W7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 16, 2012
Last sequence update: June 26, 2013
Last modified: August 12, 2020
This is version 60 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
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