UniProtKB - H9G7M3 (H9G7M3_ANOCA)
Protein
Gamma-glutamylcyclotransferase
Gene
CHAC1
Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Functioni
Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.UniRule annotation
Catalytic activityi
- EC:4.3.2.7UniRule annotationARBA annotation
GO - Molecular functioni
- gamma-glutamylcyclotransferase activity Source: GO_Central
- glutathione specific gamma-glutamylcyclotransferase activity Source: UniProtKB-EC
- Notch binding Source: Ensembl
GO - Biological processi
- glutathione catabolic process Source: GO_Central
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress Source: Ensembl
- negative regulation of Notch signaling pathway Source: Ensembl
- negative regulation of protein processing Source: Ensembl
- neurogenesis Source: Ensembl
Keywordsi
Molecular function | LyaseUniRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:CHAC1Imported |
Organismi | Anolis carolinensis (Green anole) (American chameleon)Imported |
Taxonomic identifieri | 28377 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Iguania › Dactyloidae › Anolis |
Proteomesi |
|
Subcellular locationi
Cytosol
- cytosol Source: Ensembl
Golgi apparatus
- trans-Golgi network Source: Ensembl
Other locations
- cytoplasm Source: GO_Central
Expressioni
Gene expression databases
Bgeei | ENSACAG00000003525, Expressed in female gonad and 14 other tissues |
Interactioni
GO - Molecular functioni
- Notch binding Source: Ensembl
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000003416 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 28 | DisorderedSequence analysisAdd BLAST | 28 |
Sequence similaritiesi
Belongs to the gamma-glutamylcyclotransferase family.UniRule annotation
Phylogenomic databases
eggNOGi | KOG3182, Eukaryota |
GeneTreei | ENSGT00390000003855 |
HOGENOMi | CLU_070703_2_2_1 |
InParanoidi | H9G7M3 |
OMAi | VWRPGFE |
TreeFami | TF313048 |
Family and domain databases
CDDi | cd06661, GGCT_like, 1 hit |
InterProi | View protein in InterPro IPR006840, ChaC IPR013024, GGCT-like IPR036568, GGCT-like_sf |
PANTHERi | PTHR12192, PTHR12192, 1 hit |
Pfami | View protein in Pfam PF04752, ChaC, 1 hit |
SUPFAMi | SSF110857, SSF110857, 1 hit |
i Sequence
Sequence statusi: Complete.
H9G7M3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKRDVLSKQQ QHPSSASGAE HLDEGQGQPP ASPLWVFGYG SLVWRPGFEF
60 70 80 90 100
ASRKVGYIRG YSRRFWQGDT FHRAARRWPG RVVTLQEDYN GCTWGVAYEL
110 120 130 140 150
RGDQVAASLK YLNVREAVLG GYVTKLVKFY PQEEESEEPI LALVYIATPQ
160 170 180 190 200
NPSYLGPASE EDIAAQIIVS SGRAGHNIEY LLQLADFMRY CCPQVEDEHL
210 220
FSIEEALISI LPCLYQGEET IVQE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAWZ02022526 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENSACAT00000003500; ENSACAP00000003416; ENSACAG00000003525 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAWZ02022526 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000003416 |
Genome annotation databases
Ensembli | ENSACAT00000003500; ENSACAP00000003416; ENSACAG00000003525 |
Phylogenomic databases
eggNOGi | KOG3182, Eukaryota |
GeneTreei | ENSGT00390000003855 |
HOGENOMi | CLU_070703_2_2_1 |
InParanoidi | H9G7M3 |
OMAi | VWRPGFE |
TreeFami | TF313048 |
Gene expression databases
Bgeei | ENSACAG00000003525, Expressed in female gonad and 14 other tissues |
Family and domain databases
CDDi | cd06661, GGCT_like, 1 hit |
InterProi | View protein in InterPro IPR006840, ChaC IPR013024, GGCT-like IPR036568, GGCT-like_sf |
PANTHERi | PTHR12192, PTHR12192, 1 hit |
Pfami | View protein in Pfam PF04752, ChaC, 1 hit |
SUPFAMi | SSF110857, SSF110857, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | H9G7M3_ANOCA | |
Accessioni | H9G7M3Primary (citable) accession number: H9G7M3 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 16, 2012 |
Last sequence update: | May 16, 2012 | |
Last modified: | August 12, 2020 | |
This is version 49 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |