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Entry version 61 (02 Jun 2021)
Sequence version 2 (26 Jun 2013)
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Protein
Submitted name:

Hephaestin

Gene

HEPH

Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductaseARBA annotation
LigandMetal-bindingARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
HephaestinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HEPHImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnolis carolinensis (Green anole) (American chameleon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri28377 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaIguaniaDactyloidaeAnolis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001646 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1113 – 1135HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 18Sequence analysisAdd BLAST18
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500361973119 – 1165Sequence analysisAdd BLAST1147

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi177 ↔ 203UniRule annotation
Disulfide bondi281 ↔ 362UniRule annotation
Disulfide bondi531 ↔ 557UniRule annotation
Disulfide bondi631 ↔ 712UniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotationARBA annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSACAG00000003376, Expressed in kidney and 6 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
28377.ENSACAP00000003407

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini95 – 203Plastocyanin-likeInterPro annotationAdd BLAST109
Domaini313 – 359Plastocyanin-likeInterPro annotationAdd BLAST47
Domaini452 – 556Plastocyanin-likeInterPro annotationAdd BLAST105
Domaini958 – 1071Plastocyanin-likeInterPro annotationAdd BLAST114

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the multicopper oxidase family.ARBA annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1263, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158517

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_005569_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
H9G7M0

Identification of Orthologs from Complete Genome Data

More...
OMAi
AYFHGET

TreeFam database of animal gene trees

More...
TreeFami
TF329807

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.420, 5 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011706, Cu-oxidase_2
IPR011707, Cu-oxidase_3
IPR033138, Cu_oxidase_CS
IPR002355, Cu_oxidase_Cu_BS
IPR008972, Cupredoxin
IPR024715, Factor_5/8-like
IPR027154, HEPH

The PANTHER Classification System

More...
PANTHERi
PTHR11709:SF221, PTHR11709:SF221, 5 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07731, Cu-oxidase_2, 2 hits
PF07732, Cu-oxidase_3, 2 hits

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000354, Factors_V_VIII, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49503, SSF49503, 6 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00079, MULTICOPPER_OXIDASE1, 3 hits
PS00080, MULTICOPPER_OXIDASE2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

H9G7M0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRILQAVALV HFAGIVFGDG SSRAYYLGIH EEEWNYAPVG KNGATGQSVA
60 70 80 90 100
GDDAASRFLQ RSRDRIGSVY RKSVYRQYSD ATYASEVPKP PWLGFLGPVI
110 120 130 140 150
RAEVGDTVSV HLKNFARRPF SIHPHGVFYK KDSEGSLYPD VSSQDLKVDD
160 170 180 190 200
AVPPGGSYTY VWTVPEDHGP TASDPSCLTW IYHSHVNAPR DIASGLIGPL
210 220 230 240 250
LVCREGTLKS RSQRRHDADL DFFLMFSVVD ENESWHLREN VASFCGDPDS
260 270 280 290 300
VDEEDEGFKE SNRMHAINGF AFGSLPELSM CAGDHVSWHL FGMGSERDVH
310 320 330 340 350
TAFFHGQTLV LRGHRTDVVS LFPATFVAAE MTPRNTGKWL LSCEVHDHLQ
360 370 380 390 400
AGMEALYEVK NCSYPKAEPP LKGKLRKYYI AAKEVQWNYA PSGLDQSTGK
410 420 430 440 450
SLQEPNSFSE LYFKPISSRS KGTYWKAKYI EYTDETFRVE KAQKGDERHL
460 470 480 490 500
GILGPVIKAE VGDTLQVTFA NKASWPFSVQ PHGVFYGKEW EGTPYDDGLS
510 520 530 540 550
HKGTAVRPMR NFTYRWTVPQ HVGPTDTDPS CLTWMYSSAT DPTRDTNAGL
560 570 580 590 600
VGPLLVCRPG TLDEENHQKG VDKEFYLLFG VFDENLSWYR DANLKTLNRF
610 620 630 640 650
SMHEDEVFKE SNRMHAINGF VYSNLPLLEV CKGETVSWHL LGFGGEADIH
660 670 680 690 700
GIAFQGNTIL MNGMRRDTTS LFPHTFATAL MQPDEEGAFE VYCQTSNHYQ
710 720 730 740 750
SGMKGRYSVR QCGKETPFDN QVYEKVRTFY IMAEEVEWDY APDRSWELER
760 770 780 790 800
HNRSAGERYG EVFLSHGNGL LGSKYKKAIY REYTDGTFRT QKERRNGEEH
810 820 830 840 850
LGILGPFLWA EVGDVLNIVF RNNATRPYSI HAHGVLEKSR ADPEATKPGE
860 870 880 890 900
IVTYQWDVPA RSGPGPNDSA CVSWIYYSGV DPVKDLFSGL VGPLKVCRKG
910 920 930 940 950
TLDSGGRRRG VSKEFALLFL VFDENQSWYL EENVKNHGQG ERNRSRADKE
960 970 980 990 1000
EFAESNKMHA INGRLYANLP GLTMYAGDWV NWYLLGMGQE IDVHTVHFHA
1010 1020 1030 1040 1050
ETFIYRSGQS HRADVVDLFP GTLEMADVVD LFPGTLEMVE MLASNPGTWL
1060 1070 1080 1090 1100
LHCHVADHIH AGMETLFTVL PRPDPRRLNV SSVAARPPED GDDPDHVVLF
1110 1120 1130 1140 1150
GSKLAHGKVE ATVILLAVAG IALFLIAIIL LGIIIHRERQ RRLRRNRRSI
1160
LDEGFKLVAT KSPEI
Length:1,165
Mass (Da):131,068
Last modified:June 26, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCE8C46F43C52224B
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAWZ02028491 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSACAT00000003491; ENSACAP00000003407; ENSACAG00000003376

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAWZ02028491 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi28377.ENSACAP00000003407

Genome annotation databases

EnsembliENSACAT00000003491; ENSACAP00000003407; ENSACAG00000003376

Phylogenomic databases

eggNOGiKOG1263, Eukaryota
GeneTreeiENSGT00940000158517
HOGENOMiCLU_005569_0_0_1
InParanoidiH9G7M0
OMAiAYFHGET
TreeFamiTF329807

Gene expression databases

BgeeiENSACAG00000003376, Expressed in kidney and 6 other tissues

Family and domain databases

Gene3Di2.60.40.420, 5 hits
InterProiView protein in InterPro
IPR011706, Cu-oxidase_2
IPR011707, Cu-oxidase_3
IPR033138, Cu_oxidase_CS
IPR002355, Cu_oxidase_Cu_BS
IPR008972, Cupredoxin
IPR024715, Factor_5/8-like
IPR027154, HEPH
PANTHERiPTHR11709:SF221, PTHR11709:SF221, 5 hits
PfamiView protein in Pfam
PF07731, Cu-oxidase_2, 2 hits
PF07732, Cu-oxidase_3, 2 hits
PIRSFiPIRSF000354, Factors_V_VIII, 3 hits
SUPFAMiSSF49503, SSF49503, 6 hits
PROSITEiView protein in PROSITE
PS00079, MULTICOPPER_OXIDASE1, 3 hits
PS00080, MULTICOPPER_OXIDASE2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH9G7M0_ANOCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H9G7M0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 16, 2012
Last sequence update: June 26, 2013
Last modified: June 2, 2021
This is version 61 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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