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Protein
Submitted name:

ADAM metallopeptidase domain 19

Gene

ADAM19

Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Protein family/group databases

MEROPSiM12.214

Names & Taxonomyi

Protein namesi
Submitted name:
ADAM metallopeptidase domain 19Imported
Gene namesi
Name:ADAM19Imported
OrganismiAnolis carolinensis (Green anole) (American chameleon)Imported
Taxonomic identifieri28377 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaIguaniaDactyloidaeAnolis
Proteomesi
  • UP000001646 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei696 – 722HelicalSequence analysisAdd BLAST27

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_500361972920 – 911Sequence analysisAdd BLAST892

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi470 ↔ 490PROSITE-ProRule annotation
Disulfide bondi650 ↔ 660PROSITE-ProRule annotation
Disulfide bondi668 ↔ 677PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Expressioni

Gene expression databases

BgeeiENSACAG00000003397

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi28377.ENSACAP00000003391

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini206 – 404Peptidase M12BInterPro annotationAdd BLAST199
Domaini412 – 498DisintegrinInterPro annotationAdd BLAST87
Domaini646 – 678EGF-likeInterPro annotationAdd BLAST33

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3607 Eukaryota
ENOG410XX2M LUCA
GeneTreeiENSGT00910000144014
InParanoidiH9G7L1
KOiK08608
OrthoDBiEOG091G01NX
TreeFamiTF314733

Family and domain databases

CDDicd04269 ZnMc_adamalysin_II_like, 1 hit
Gene3Di3.40.390.10, 1 hit
4.10.70.10, 1 hit
InterProiView protein in InterPro
IPR033596 ADAM19
IPR006586 ADAM_Cys-rich
IPR001762 Disintegrin_dom
IPR036436 Disintegrin_dom_sf
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR024079 MetalloPept_cat_dom_sf
IPR001590 Peptidase_M12B
IPR002870 Peptidase_M12B_N
IPR034027 Reprolysin_adamalysin
PANTHERiPTHR11905:SF19 PTHR11905:SF19, 1 hit
PfamiView protein in Pfam
PF08516 ADAM_CR, 1 hit
PF00200 Disintegrin, 1 hit
PF01562 Pep_M12B_propep, 1 hit
PF01421 Reprolysin, 1 hit
PRINTSiPR00289 DISINTEGRIN
SMARTiView protein in SMART
SM00608 ACR, 1 hit
SM00050 DISIN, 1 hit
SUPFAMiSSF57552 SSF57552, 1 hit
PROSITEiView protein in PROSITE
PS50215 ADAM_MEPRO, 1 hit
PS50214 DISINTEGRIN_2, 1 hit
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 1 hit

Sequencei

Sequence statusi: Complete.

H9G7L1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGLPWLPLV VLWLRQVSAQ EEEAPGTGKR EIVNFQTHHE IIIPLWRAYG
60 70 80 90 100
SSGNNQHSPR AEVSITVEGK YLILDVEKNK DLFAPGYTET HYTQSGLPQT
110 120 130 140 150
VMVNKTDHCF YHGIVRGMED SSVALSTCNG LRGLIVLRNN LSYILEPLPH
160 170 180 190 200
NQEQHLIYRS EHLKVPRGSC GNQNSEFWAI DWFNELASRA EPGYHRVKRD
210 220 230 240 250
DQQSMKYVEL LLVADYAEYQ KHNYDLQATK NKLVEAANYV DKFYKSLNIR
260 270 280 290 300
IALVGLEVWN DHNMCEISEN PHSTLWSFLS WRRKILKYRK HDNAQLITGM
310 320 330 340 350
SFHGTTIGLA PLMAMCSAYQ SGGVNMDHSD NAIGVAATMA HEMGHNFGMS
360 370 380 390 400
HDSTGCCTAS AKDGGCIMAA ATGHPFPRVF NNCNKKELDR YLQSGGGMCL
410 420 430 440 450
YNMPDTKTLY GGQRCGNGYL EEGEECDCGE VEECNNPCCN AADCSLKPGA
460 470 480 490 500
ECAHGTCCHL CKLIAPGSLC RDQARSCDLP EYCTGKSPFC PANFYQLDGT
510 520 530 540 550
PCADGRAYCY SGMCLTYEQQ CSQLWGYGAR PAPDLCFEKV NAAGDSYGNC
560 570 580 590 600
GKDINGRYKK CNTRDAKCGK IQCQSSASKP LESNAVAIDT TILLNGRQIL
610 620 630 640 650
CRGTHVYRNE ENEGDMLDPG LVMAGTKCGD SHICFEGHCR NTSFFETGDC
660 670 680 690 700
DKKCNDHGVC NNNQNCHCFS GWAPPFCDKS GNGGSLDSGP MPPKDLLPII
710 720 730 740 750
VGVMVFIVFL IVIGVVFCCY KWRTKLVPLK KMITTPKETQ QFSTPPPIQN
760 770 780 790 800
VANGHANPAF KLKTPQEQRK VLGTQNIPPK PEVLYCQPPP ELGVHTRPPP
810 820 830 840 850
PLPANYTRKP PIPAGQSETK YLPRRTPPNR PAPPAPKITV SQNSSRPQPP
860 870 880 890 900
QKALPANPVP GSNRAGLPRI NTGTAAGPSH GSSRSVGIHR TLTENSAIKS
910
TGAVNTLKFQ S
Length:911
Mass (Da):100,198
Last modified:June 26, 2013 - v2
Checksum:iC0CBDD9720BB3200
GO

Sequence databases

RefSeqiXP_003223525.2, XM_003223477.3

Genome annotation databases

EnsembliENSACAT00000003474; ENSACAP00000003391; ENSACAG00000003397
GeneIDi100554500
KEGGiacs:100554500

Similar proteinsi

Entry informationi

Entry nameiH9G7L1_ANOCA
AccessioniPrimary (citable) accession number: H9G7L1
Entry historyiIntegrated into UniProtKB/TrEMBL: May 16, 2012
Last sequence update: June 26, 2013
Last modified: July 18, 2018
This is version 42 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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