UniProtKB - H9G7K7 (H9G7K7_ANOCA)
Protein
Sodium/potassium-transporting ATPase subunit alpha
Gene
ATP1A1
Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Functioni
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- chaperone binding Source: Ensembl
- metal ion binding Source: UniProtKB-KW
- sodium:potassium-exchanging ATPase activity Source: GO_Central
- steroid hormone binding Source: Ensembl
GO - Biological processi
- cellular potassium ion homeostasis Source: GO_Central
- cellular response to steroid hormone stimulus Source: Ensembl
- cellular sodium ion homeostasis Source: GO_Central
- membrane repolarization Source: Ensembl
- potassium ion import across plasma membrane Source: GO_Central
- proton transmembrane transport Source: GO_Central
- response to glycoside Source: Ensembl
- sodium ion export across plasma membrane Source: GO_Central
Keywordsi
Molecular function | TranslocaseARBA annotation |
Biological process | Ion transport, Potassium transportUniRule annotation, Transport |
Ligand | ATP-bindingUniRule annotationARBA annotation, MagnesiumARBA annotation, Metal-bindingUniRule annotationARBA annotation, Nucleotide-binding, Potassium |
Names & Taxonomyi
Protein namesi | Recommended name: Sodium/potassium-transporting ATPase subunit alphaUniRule annotation |
Gene namesi | Name:ATP1A1Imported |
Organismi | Anolis carolinensis (Green anole) (American chameleon)Imported |
Taxonomic identifieri | 28377 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Iguania › Dactyloidae › Anolis |
Proteomesi |
|
Subcellular locationi
Other locations
- Membrane UniRule annotation
Plasma Membrane
- apical plasma membrane Source: Ensembl
- lateral plasma membrane Source: Ensembl
- sodium:potassium-exchanging ATPase complex Source: Ensembl
- T-tubule Source: Ensembl
Other locations
- organelle membrane Source: Ensembl
- sperm flagellum Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 95 – 117 | HelicalUniRule annotationAdd BLAST | 23 | |
Transmembranei | 129 – 148 | HelicalUniRule annotationAdd BLAST | 20 | |
Transmembranei | 290 – 314 | HelicalUniRule annotationAdd BLAST | 25 | |
Transmembranei | 320 – 343 | HelicalUniRule annotationAdd BLAST | 24 | |
Transmembranei | 852 – 873 | HelicalUniRule annotationAdd BLAST | 22 | |
Transmembranei | 912 – 931 | HelicalUniRule annotationAdd BLAST | 20 | |
Transmembranei | 952 – 969 | HelicalUniRule annotationAdd BLAST | 18 | |
Transmembranei | 984 – 1000 | HelicalUniRule annotationAdd BLAST | 17 |
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | ENSACAG00000003402, Expressed in kidney and 14 other tissues |
Interactioni
GO - Molecular functioni
- chaperone binding Source: Ensembl
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000003383 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 41 – 115 | Cation_ATPase_NInterPro annotationAdd BLAST | 75 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 33 | DisorderedSequence analysisAdd BLAST | 33 | |
Regioni | 214 – 234 | DisorderedSequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily. [View classification]UniRule annotationARBA annotation
Keywords - Domaini
Transmembrane, Transmembrane helixUniRule annotationARBA annotationPhylogenomic databases
eggNOGi | KOG0203, Eukaryota |
GeneTreei | ENSGT00940000154840 |
HOGENOMi | CLU_002360_4_1_1 |
InParanoidi | H9G7K7 |
OrthoDBi | 100699at2759 |
TreeFami | TF312838 |
Family and domain databases
CDDi | cd02608, P-type_ATPase_Na-K_like, 1 hit |
Gene3Di | 3.40.1110.10, 1 hit 3.40.50.1000, 1 hit |
InterProi | View protein in InterPro IPR006068, ATPase_P-typ_cation-transptr_C IPR004014, ATPase_P-typ_cation-transptr_N IPR023299, ATPase_P-typ_cyto_dom_N IPR018303, ATPase_P-typ_P_site IPR023298, ATPase_P-typ_TM_dom_sf IPR008250, ATPase_P-typ_transduc_dom_A_sf IPR036412, HAD-like_sf IPR023214, HAD_sf IPR005775, P-type_ATPase_IIC IPR001757, P_typ_ATPase |
Pfami | View protein in Pfam PF00689, Cation_ATPase_C, 1 hit PF00690, Cation_ATPase_N, 1 hit |
SMARTi | View protein in SMART SM00831, Cation_ATPase_N, 1 hit |
SUPFAMi | SSF56784, SSF56784, 1 hit SSF81653, SSF81653, 1 hit SSF81660, SSF81660, 1 hit SSF81665, SSF81665, 1 hit |
TIGRFAMsi | TIGR01106, ATPase-IIC_X-K, 1 hit TIGR01494, ATPase_P-type, 2 hits |
PROSITEi | View protein in PROSITE PS00154, ATPASE_E1_E2, 1 hit |
i Sequence
Sequence statusi: Complete.
H9G7K7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGKGTGRDKY EPAATNEHGA KTKKGKKERD MEELKKEVSL DDHKLTLDEL
60 70 80 90 100
HQKYGTDLSR GLTPARAAEI LARDGPNALT PPPTTPEWVK FCRQLFGGFS
110 120 130 140 150
LLLWIGAILC FLAYGIQAAT EEEPNNDNLY LGVVLAAVVI VTGCFSYYQE
160 170 180 190 200
AKSSKIMESF KNMVPQQALV IRSGEKLSIN AEGVVVGDLV EVKGGDRIPA
210 220 230 240 250
DLRIISAHGC KVDNSSLTGE SEPQTRSPEF TNENPLETRN IGFFSTNCVE
260 270 280 290 300
GTARGVVINT GDRTVMGRIA TLASGLEGGR TPIAVEIEHF IHIITGVAVF
310 320 330 340 350
LGVSFFILSL ILEYTWLEAV IFLIGIIVAN VPEGLLATVT VCLTLTAKRM
360 370 380 390 400
ARKNCLVKNL EAVETLGSTS TICSDKTGTL TQNRMTVAHM WFDNQIHEAD
410 420 430 440 450
TTENQSGASF DKTSPTWTAL ARIAGLCNRA VFQANQENVP ILKRLVAGDA
460 470 480 490 500
SESALLKCIE LCCGSVKELR EKNPKVVEIP FNSTNKYQLS IHNNANPSES
510 520 530 540 550
RYLLVMKGAP ERILDRCSTI LVHGKEQPLD EEAKDAFQNA YLELGGLGER
560 570 580 590 600
VLGFCHLALP DEQFPEGFQF DTDDVNFPVD NLCFVGLISM IDPPRAAVPD
610 620 630 640 650
AVGKCRSAGI KVIMVTGDHP ITAKAIAKGV GIISEGNETV EDIALRLNIP
660 670 680 690 700
VSQVNPRDAK ACVIHGSDLK DMTSEQLDDI LTHHTEIVFA RTSPQQKLII
710 720 730 740 750
VEGCQRQGAI VAVTGDGVND SPALKKADIG VAMGIAGSDV SKQAADMILL
760 770 780 790 800
DDNFASIVTG VEEGRLIFDN LKKSIAYTLT SNIPEITPFL IFIIANIPLP
810 820 830 840 850
LGTVTILCID LGTDMVPAIS LAYEQAESDI MKRQPRNPKT DKLVNERLIS
860 870 880 890 900
TAYGQIGMIQ ALGGFFTYFV ILAENGFLPS SLLGIRVSWD DRWINDVEDS
910 920 930 940 950
YGQQWTYEQR KIVEFTCHTS FFVSIVVVQW ADLIICKTRR NSVFQQGMKN
960 970 980 990 1000
KILIFGLFEE TALAAFLSYC PGMDVALRMY PLKPTWWFCA FPYSLLIFVY
1010 1020
DEVRKLIIRR SPGGWVEKET YY
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAWZ02027390 Genomic DNA No translation available. |
RefSeqi | XP_008117951.1, XM_008119744.2 |
Genome annotation databases
Ensembli | ENSACAT00000003466; ENSACAP00000003383; ENSACAG00000003402 |
GeneIDi | 100564542 |
KEGGi | acs:100564542 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAWZ02027390 Genomic DNA No translation available. |
RefSeqi | XP_008117951.1, XM_008119744.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000003383 |
Genome annotation databases
Ensembli | ENSACAT00000003466; ENSACAP00000003383; ENSACAG00000003402 |
GeneIDi | 100564542 |
KEGGi | acs:100564542 |
Phylogenomic databases
eggNOGi | KOG0203, Eukaryota |
GeneTreei | ENSGT00940000154840 |
HOGENOMi | CLU_002360_4_1_1 |
InParanoidi | H9G7K7 |
OrthoDBi | 100699at2759 |
TreeFami | TF312838 |
Gene expression databases
Bgeei | ENSACAG00000003402, Expressed in kidney and 14 other tissues |
Family and domain databases
CDDi | cd02608, P-type_ATPase_Na-K_like, 1 hit |
Gene3Di | 3.40.1110.10, 1 hit 3.40.50.1000, 1 hit |
InterProi | View protein in InterPro IPR006068, ATPase_P-typ_cation-transptr_C IPR004014, ATPase_P-typ_cation-transptr_N IPR023299, ATPase_P-typ_cyto_dom_N IPR018303, ATPase_P-typ_P_site IPR023298, ATPase_P-typ_TM_dom_sf IPR008250, ATPase_P-typ_transduc_dom_A_sf IPR036412, HAD-like_sf IPR023214, HAD_sf IPR005775, P-type_ATPase_IIC IPR001757, P_typ_ATPase |
Pfami | View protein in Pfam PF00689, Cation_ATPase_C, 1 hit PF00690, Cation_ATPase_N, 1 hit |
SMARTi | View protein in SMART SM00831, Cation_ATPase_N, 1 hit |
SUPFAMi | SSF56784, SSF56784, 1 hit SSF81653, SSF81653, 1 hit SSF81660, SSF81660, 1 hit SSF81665, SSF81665, 1 hit |
TIGRFAMsi | TIGR01106, ATPase-IIC_X-K, 1 hit TIGR01494, ATPase_P-type, 2 hits |
PROSITEi | View protein in PROSITE PS00154, ATPASE_E1_E2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | H9G7K7_ANOCA | |
Accessioni | H9G7K7Primary (citable) accession number: H9G7K7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 16, 2012 |
Last sequence update: | June 26, 2013 | |
Last modified: | December 2, 2020 | |
This is version 69 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |