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Entry version 54 (07 Oct 2020)
Sequence version 1 (16 May 2012)
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Protein
Submitted name:

Uncharacterized protein

Gene
N/A
Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi1716 – 1727PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi1752 – 1763PROSITE-ProRule annotationAdd BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-bindingARBA annotation
LigandCalciumPROSITE-ProRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnolis carolinensis (Green anole) (American chameleon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri28377 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaIguaniaDactyloidaeAnolis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001646 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membraneARBA annotation, Cell projectionARBA annotation, Membrane

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSACAG00000002949, Expressed in heart and 14 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
28377.ENSACAP00000003198

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1703 – 1738EF-handInterPro annotationAdd BLAST36
Domaini1739 – 1774EF-handInterPro annotationAdd BLAST36
Domaini1779 – 1857GARInterPro annotationAdd BLAST79

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1607 – 1646DisorderedSequence analysisAdd BLAST40
Regioni1860 – 2075DisorderedSequence analysisAdd BLAST216

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili754 – 774Sequence analysisAdd BLAST21
Coiled coili819 – 839Sequence analysisAdd BLAST21
Coiled coili1093 – 1113Sequence analysisAdd BLAST21
Coiled coili1533 – 1553Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1607 – 1623PolyampholyteSequence analysisAdd BLAST17
Compositional biasi1624 – 1646PolarSequence analysisAdd BLAST23
Compositional biasi1867 – 1883PolarSequence analysisAdd BLAST17
Compositional biasi1915 – 1995PolarSequence analysisAdd BLAST81
Compositional biasi2002 – 2016PolarSequence analysisAdd BLAST15
Compositional biasi2023 – 2045PolarSequence analysisAdd BLAST23
Compositional biasi2057 – 2075PolarSequence analysisAdd BLAST19

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0516, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155824

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001588_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
H9G7B1

Identification of Orthologs from Complete Genome Data

More...
OMAi
PQFGDSQ

TreeFam database of animal gene trees

More...
TreeFami
TF322393

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00051, EFh, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.920.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029926, Dystonin-like
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR003108, GAR_dom
IPR036534, GAR_dom_sf
IPR043197, Plakin
IPR018159, Spectrin/alpha-actinin
IPR002017, Spectrin_repeat

The PANTHER Classification System

More...
PANTHERi
PTHR23169, PTHR23169, 2 hits
PTHR23169:SF24, PTHR23169:SF24, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13499, EF-hand_7, 1 hit
PF02187, GAS2, 1 hit
PF00435, Spectrin, 11 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00054, EFh, 2 hits
SM00243, GAS2, 1 hit
SM00150, SPEC, 15 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF143575, SSF143575, 1 hit
SSF47473, SSF47473, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00018, EF_HAND_1, 2 hits
PS50222, EF_HAND_2, 2 hits
PS51460, GAR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

H9G7B1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
RQNQLEEILV LAKQFHETSE PISDWLSVTE KKLANSEPIG TQTPKIQQQI
60 70 80 90 100
TRHKALAEET ESHAPAVAQA VSLGQSLSAL SCRPDQASLA EKLDLLQSRY
110 120 130 140 150
AEVCERCGRK AALLDQALVN ARLFGEDEVE VLNWLGEVQV KLDLVAIKDY
160 170 180 190 200
KWDVLHRQHA DQMTLNDEIM NRKKNVDQAI KNGQALLKQT TGEEVLLIQE
210 220 230 240 250
KLDGIKTRYA DITASSAKAL RTLEQARQLA AKFQSTYEEL TAWMSQVEQE
260 270 280 290 300
LGSGGGLSPV GEQIPQFQQR QKDLKKQVME RRLVLDTVNE VSRALSELVP
310 320 330 340 350
WRARGSLEKT VSDTNEHYKQ ISDTIKQRVE EIDAAIQRSQ QYEQAADAEL
360 370 380 390 400
AWVAETKRKL MALGPVRLEQ EHTTAQLQVQ KAFSIDIIRH KDSVDELLSQ
410 420 430 440 450
RDDIFGTCGK EQKAILQEKT ESLLQQYDDI SHLNSERYAR LERAQVLVNQ
460 470 480 490 500
FWETHEELNP WLEETQTLIG QLPPPAIDYE HLKQQQEDMR QLRESIAEHK
510 520 530 540 550
PHIDKLLKIG PQLKELNPEE GEMVQEKYQA AETTYLHIKE EVRQRALALD
560 570 580 590 600
EAVSQSTQFH DKIEPMLETL ESLSSRLRMP PLIPAEVEKI RECISENKNA
610 620 630 640 650
TMELEKLQPS FQALKRRGEE LVGRSQGIDK DPAAKEIQDK LDKMLFFWED
660 670 680 690 700
IRARAEEREI KFLDVLELAE KFWYDMAALL TTIRDTQDIV HDLESPGIDP
710 720 730 740 750
SIIKQQMEAA ETIKAETDSL HEELEFIRIL GTDLIFACGE TEKPEVKKSI
760 770 780 790 800
DEMNSAWENL NKTWKERLER LEEAMQSAVL YQDTLQAMFD WLDNTVIKLC
810 820 830 840 850
NMPPVGTDLN TVKEQLKEMK EFKTEVYQQQ IEMEKLNHQG EIMLKKAADE
860 870 880 890 900
TDRDIIRRPL TELKHLWENL GDKIADRQHK LEGALLALGQ FQHALAELMA
910 920 930 940 950
WLTHTEQLLD AQKPIKGDPK VIEVELAKHH VLKNDVLAHQ ATVETVNKAG
960 970 980 990 1000
DELLQSTAGD DASKLRDRLD AMVLCWETVL CKTEEREQQL QMTLQQAQGF
1010 1020 1030 1040 1050
HGEIDDFLQW LTRMENQLSA SKPTGGLPET AREQLNAHME LYAQFKANET
1060 1070 1080 1090 1100
VFGQLLDKGR FMLLGRDDCG SGSKTEQSVA LLEQKWNIVS SKMEERKTKL
1110 1120 1130 1140 1150
EEALRLAAEF QNSLQDFINW LTFAEQSLNV APPPSLILTM VLSQIEDHKV
1160 1170 1180 1190 1200
FANEVNAHRD QIIGLDQSGN QLKFLSQKQD VVLIKNLLVS VQSRWEKVVQ
1210 1220 1230 1240 1250
RSVERGRALD DARKRAKQFH EAWKKLVDWL EDAENHLDSD LEISNDPDKI
1260 1270 1280 1290 1300
KLQLSKHKEF QKTLGGKQPV YDTTIRTGRA LKEKAQFSDD GQSLDHLLGE
1310 1320 1330 1340 1350
VRDRWDTVCG KSVERQHKLE EALLFSGQFM DALQALVDWL YKVEPQLAED
1360 1370 1380 1390 1400
QPVHGDLDLV MNLIDAHKVF QKELGKRTGT VQVLKRSGRE LIENSRDDTT
1410 1420 1430 1440 1450
WVKVQLQELS NRWDTVCKMS VLKQIRLEQA FKQAEEFRTA VHLLLDWLSE
1460 1470 1480 1490 1500
AEQTLRFRGA LPDDAEALQS LIDTHKEFMK KVEEKISDVT MAVGMGEVIL
1510 1520 1530 1540 1550
AVCHPDCITT IKHWITIIRA RFEEVLAWAK QHQQRLEAAL SELVANAQLL
1560 1570 1580 1590 1600
EQLLAWIQWA ETALIQRDQD PMPQNIDQVK ALIAEHQSFM EEMTRKQPDV
1610 1620 1630 1640 1650
DRVTKTYKRK ATEPSHGPLS EKSRSNRKSL TQPSPPLMPV LSQSEAKNPR
1660 1670 1680 1690 1700
INQLSARWQQ VWLLALERQR KLNDALDRLE ELKEFANFDF DVWRKKYMRW
1710 1720 1730 1740 1750
MNHKKSRVMD FFRRIDKDQD GKITRQEFID GILASKFPTT KLEMTAVADI
1760 1770 1780 1790 1800
FDRDGDGYID YYEFVAALHP NKDAYRPTTD ADKIEDEVTR QVAQCKCAKR
1810 1820 1830 1840 1850
FQVEQIGENK YRFFLGNQFG DSQQLRLVRI LRSTVMVRVG GGWMALDEFL
1860 1870 1880 1890 1900
VKNDPCRVHH PGSKIKRSDS SSSIASQSPI ARGRTNLELR EKFILPEGAS
1910 1920 1930 1940 1950
QGMAPFRSRG RRSKPSSRAA SPTRSSSSAS QSNHSCTSMP SSPATPASGT
1960 1970 1980 1990 2000
KQGQVAPSSS SKLKRPTFHS SRTSLAGDTS NSSSPVSSGA KTNRADPKKT
2010 2020 2030 2040 2050
TSRPTSRAGS RASSRRGSDA SDFDLETQSA CSDTSESSAT GGQGGSRRGT
2060 2070
GAKPSKIPTI TKKTPTANTA VSPKM
Length:2,075
Mass (Da):236,199
Last modified:May 16, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5F91EB39D94ECB5B
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAWZ02028783 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSACAT00000003281; ENSACAP00000003198; ENSACAG00000002949

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAWZ02028783 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi28377.ENSACAP00000003198

Genome annotation databases

EnsembliENSACAT00000003281; ENSACAP00000003198; ENSACAG00000002949

Phylogenomic databases

eggNOGiKOG0516, Eukaryota
GeneTreeiENSGT00940000155824
HOGENOMiCLU_001588_0_0_1
InParanoidiH9G7B1
OMAiPQFGDSQ
TreeFamiTF322393

Gene expression databases

BgeeiENSACAG00000002949, Expressed in heart and 14 other tissues

Family and domain databases

CDDicd00051, EFh, 1 hit
Gene3Di3.30.920.20, 1 hit
InterProiView protein in InterPro
IPR029926, Dystonin-like
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR003108, GAR_dom
IPR036534, GAR_dom_sf
IPR043197, Plakin
IPR018159, Spectrin/alpha-actinin
IPR002017, Spectrin_repeat
PANTHERiPTHR23169, PTHR23169, 2 hits
PTHR23169:SF24, PTHR23169:SF24, 2 hits
PfamiView protein in Pfam
PF13499, EF-hand_7, 1 hit
PF02187, GAS2, 1 hit
PF00435, Spectrin, 11 hits
SMARTiView protein in SMART
SM00054, EFh, 2 hits
SM00243, GAS2, 1 hit
SM00150, SPEC, 15 hits
SUPFAMiSSF143575, SSF143575, 1 hit
SSF47473, SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018, EF_HAND_1, 2 hits
PS50222, EF_HAND_2, 2 hits
PS51460, GAR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH9G7B1_ANOCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H9G7B1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 16, 2012
Last sequence update: May 16, 2012
Last modified: October 7, 2020
This is version 54 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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