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UniProtKB - H9G760 (H9G760_ANOCA)

Entry version 58 (10 Feb 2021)
Sequence version 1 (16 May 2012)
Previous versions | rss
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Protein

DNA helicase

Gene

WRN

Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandATP-bindingARBA annotation, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA helicaseARBA annotation (EC:3.6.4.12ARBA annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:WRNImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnolis carolinensis (Green anole) (American chameleon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri28377 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Iguania › Dactyloidae › Anolis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001646 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusARBA annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSACAG00000003109, Expressed in forelimb bud and 13 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		28377.ENSACAP00000003095

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini513 – 674Helicase ATP-bindingInterPro annotationAdd BLAST162
Domaini699 – 858Helicase C-terminalInterPro annotationAdd BLAST160
Domaini1109 – 1188HRDCInterPro annotationAdd BLAST80

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni349 – 370DisorderedSequence analysisAdd BLAST22

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili382 – 402Sequence analysisAdd BLAST21
Coiled coili456 – 476Sequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the helicase family. RecQ subfamily.ARBA annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0351, Eukaryota
KOG4373, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159168

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_001103_11_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		H9G760

Identification of Orthologs from Complete Genome Data

More...OMAi		CFPNSEE

TreeFam database of animal gene trees

More...TreeFami		TF312852

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.10.10, 1 hit
3.30.420.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002562, 3'-5'_exonuclease_dom
IPR011545, DEAD/DEAH_box_helicase_dom
IPR004589, DNA_helicase_ATP-dep_RecQ
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR029491, Helicase_HTH
IPR010997, HRDC-like_sf
IPR002121, HRDC_dom
IPR027417, P-loop_NTPase
IPR012337, RNaseH-like_sf
IPR036397, RNaseH_sf
IPR018982, RQC_domain
IPR036388, WH-like_DNA-bd_sf
IPR036390, WH_DNA-bd_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00270, DEAD, 1 hit
PF01612, DNA_pol_A_exo1, 1 hit
PF00271, Helicase_C, 1 hit
PF00570, HRDC, 1 hit
PF14493, HTH_40, 1 hit
PF09382, RQC, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00474, 35EXOc, 1 hit
SM00487, DEXDc, 1 hit
SM00490, HELICc, 1 hit
SM00341, HRDC, 1 hit
SM00956, RQC, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF46785, SSF46785, 1 hit
SSF47819, SSF47819, 1 hit
SSF52540, SSF52540, 1 hit
SSF53098, SSF53098, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00614, recQ_fam, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit
PS50967, HRDC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

H9G760-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNMGSPPNKL PHWMTEEEDE CSIMKQKNSA NRSVLEQNLP FLEFPGSVIY 
        60         70         80         90        100
SYNASDCSLL AEDIISMLPD GAVLGFDIEW TPVFTKGKEG KVALIQLCES 
       110        120        130        140        150
EEKCYLFHIS SMSNFPGGLK RLLEDNHIKK IGVGIEGDKW KLMRDFEVNL 
       160        170        180        190        200
GDLVDLADLA NKKLRCKEIW SLNDLVKHLF HKQLLKEKLV RCGNWEEFPL 
       210        220        230        240        250
TEEQKLYAAT DAYAGFLIYK KLMTMSSDKK LQISIEKDGI LLSSEIKKEL 
       260        270        280        290        300
ATMSEEMIDL TDHLPCTLDK SINIQRISEI LSGLSENIKA LRRVLLLDSA 
       310        320        330        340        350
CQMELGDAEN SGKITRNKEK LETSELPSKL IRESNDHVDH LDHFQNDILV 
       360        370        380        390        400
EDEEEPNNKN QAEDVSNERT KAAGEYGYLM SLDITEYELQ MLERQAEEEL 
       410        420        430        440        450
LNEAACKSED LSFTENEGKS LCVIESDDEF EMEMIKSLEN IDKHDMDVGD 
       460        470        480        490        500
SHLDKLKKEN DMIVDYDDED DEIEEEEESW DSSLPGPNSK QTACLKMYFG 
       510        520        530        540        550
HSNFKLVQWK VISSVLQDRR DNLVVMATGY GKSLCFQFPP VYTGGTGIVI 
       560        570        580        590        600
SPLISLMEDQ VLQLEMSGVQ ACLLGSAQSK NIRGDIKAGH YRVVYITPEF 
       610        620        630        640        650
CSGNLTWLEE LDQTIVITVF TNLAPKYHDI LKTFTTKGHP DSMLPNVPII 
       660        670        680        690        700
ALTATASPSI RKDIVDCLNL KNPQITCTSF DRPNLYLEVG RKTGNIIRDL 
       710        720        730        740        750
KQFLIKKDTS TYEFEGPSIV YCPSRKITEQ VSAELMKLNL ACGTYHAGMG 
       760        770        780        790        800
IKERRNIHHK FMRDEIQCIV ATVAFGMGIN KADIRTVIHY GAPKEMESYY 
       810        820        830        840        850
QEIGRAGRDG LPASCHVLWT PADLSFNSHF AFIDSIHNST YITRTRKNIV 
       860        870        880        890        900
SMSTKKLNQR QIRWALFFSR FNFKCTSRCD CFYHFLEPLP CRERLNLWEA 
       910        920        930        940        950
FNLVEKEDSF EDFGQQAYKL MSAVCALNER FGMGVPVLFL RGSNSQRVPD 
       960        970        980        990       1000
RYRTHALFGS GKDWPENLWK ALGRSLVLEG FLKEVSGINK FSTICTLSAK 
      1010       1020       1030       1040       1050
GKDWLCKAKE NSSPKLLLLM NEDLYLKTPS LPSCTVNPLT PEKKQNTNNV 
      1060       1070       1080       1090       1100
CVLSLIQKKT SLHEMFAYQG ASNTSRGSTL SSKSNATVQL PLPLAPVSPT 
      1110       1120       1130       1140       1150
VPAVSQREKE LQTALYGKLV AARQKLANEK DIPPAVLATN KVLVDMTTIR 
      1160       1170       1180       1190       1200
PTTIESIKRI DGVSEAKSAM LESLLIMIKE FSQTNNLQTD IFKTSGSQDQ 
      1210       1220       1230       1240       1250
PNIILQKRSE CGTLTESERV TYTLFQEKNM SLRSVCESRS LPLTVVGTHL 
      1260       1270       1280       1290       1300
SQALKADYPV DLERAGLTPE IQEMITKIIQ NPPINSDVTQ MKAIRTLVPA 
      1310 
HVEMYLIRMT VMLLE
Length:1,315
Mass (Da):148,562
Last modified:May 16, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0C744636D6CB40D7
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AAWZ02022228 Genomic DNA No translation available.
AAWZ02022229 Genomic DNA No translation available.
AAWZ02022230 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSACAT00000003174; ENSACAP00000003095; ENSACAG00000003109

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAWZ02022228 Genomic DNA No translation available.
AAWZ02022229 Genomic DNA No translation available.
AAWZ02022230 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi28377.ENSACAP00000003095

Genome annotation databases

EnsembliENSACAT00000003174; ENSACAP00000003095; ENSACAG00000003109

Phylogenomic databases

eggNOGiKOG0351, Eukaryota
KOG4373, Eukaryota
GeneTreeiENSGT00940000159168
HOGENOMiCLU_001103_11_1_1
InParanoidiH9G760
OMAiCFPNSEE
TreeFamiTF312852

Gene expression databases

BgeeiENSACAG00000003109, Expressed in forelimb bud and 13 other tissues

Family and domain databases

Gene3Di1.10.10.10, 1 hit
3.30.420.10, 1 hit
InterProiView protein in InterPro
IPR002562, 3'-5'_exonuclease_dom
IPR011545, DEAD/DEAH_box_helicase_dom
IPR004589, DNA_helicase_ATP-dep_RecQ
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR029491, Helicase_HTH
IPR010997, HRDC-like_sf
IPR002121, HRDC_dom
IPR027417, P-loop_NTPase
IPR012337, RNaseH-like_sf
IPR036397, RNaseH_sf
IPR018982, RQC_domain
IPR036388, WH-like_DNA-bd_sf
IPR036390, WH_DNA-bd_sf
PfamiView protein in Pfam
PF00270, DEAD, 1 hit
PF01612, DNA_pol_A_exo1, 1 hit
PF00271, Helicase_C, 1 hit
PF00570, HRDC, 1 hit
PF14493, HTH_40, 1 hit
PF09382, RQC, 1 hit
SMARTiView protein in SMART
SM00474, 35EXOc, 1 hit
SM00487, DEXDc, 1 hit
SM00490, HELICc, 1 hit
SM00341, HRDC, 1 hit
SM00956, RQC, 1 hit
SUPFAMiSSF46785, SSF46785, 1 hit
SSF47819, SSF47819, 1 hit
SSF52540, SSF52540, 1 hit
SSF53098, SSF53098, 1 hit
TIGRFAMsiTIGR00614, recQ_fam, 1 hit
PROSITEiView protein in PROSITE
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit
PS50967, HRDC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH9G760_ANOCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H9G760
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 16, 2012
Last sequence update: May 16, 2012
Last modified: February 10, 2021
This is version 58 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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