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Entry version 60 (02 Dec 2020)
Sequence version 2 (26 Jun 2013)
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Protein
Submitted name:

Misshapen like kinase 1

Gene

MINK1

Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Misshapen like kinase 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MINK1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnolis carolinensis (Green anole) (American chameleon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri28377 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaIguaniaDactyloidaeAnolis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001646 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSACAG00000003068, Expressed in skeletal muscle tissue and 15 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
28377.ENSACAP00000003063

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 248Protein kinaseInterPro annotationAdd BLAST248
Domaini989 – 1276CNHInterPro annotationAdd BLAST288

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni266 – 307DisorderedSequence analysisAdd BLAST42
Regioni321 – 341DisorderedSequence analysisAdd BLAST21
Regioni354 – 449DisorderedSequence analysisAdd BLAST96
Regioni462 – 748DisorderedSequence analysisAdd BLAST287
Regioni828 – 849DisorderedSequence analysisAdd BLAST22
Regioni861 – 905DisorderedSequence analysisAdd BLAST45

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili16 – 36Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi280 – 294AcidicSequence analysisAdd BLAST15
Compositional biasi321 – 339PolarSequence analysisAdd BLAST19
Compositional biasi354 – 446PolyampholyteSequence analysisAdd BLAST93
Compositional biasi502 – 588PolarSequence analysisAdd BLAST87
Compositional biasi617 – 634PolarSequence analysisAdd BLAST18
Compositional biasi658 – 673PolyampholyteSequence analysisAdd BLAST16
Compositional biasi866 – 902PolarSequence analysisAdd BLAST37

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0587, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183196

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001831_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
H9G748

TreeFam database of animal gene trees

More...
TreeFami
TF105138

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001180, CNH_dom
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
IPR008271, Ser/Thr_kinase_AS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00780, CNH, 1 hit
PF00069, Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00036, CNH, 1 hit
SM00220, S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50219, CNH, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

H9G748-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
QGRHVKTGQL AAIKVMDVTE DEEEEIKQEI NMLKKYSHHR NIATYYGAFV
60 70 80 90 100
KKSPPGNDDQ LWLVMEFCGA GSVTDLVKNT KGNALKEDCI AYICREILRG
110 120 130 140 150
LAHHAHKVIH RDIKGQNVLL TENAEVKLVD FGVSAQLDRT VGRRNTFIGT
160 170 180 190 200
PYWMAPEVIA CDENPDATYD YRSDIWSLGI TAIEMAEGAP PLCDMHPMRA
210 220 230 240 250
LFLIPRNPPP KLKSKKWSKK FIDFIDNCLI KAYTSRPSTE QLLKFPFIRD
260 270 280 290 300
QPTERQVRIQ LKDHIDRTRK KRGEKDETEY EYSGSEEEDE GRGEEGEPSS
310 320 330 340 350
IMNVPGESTL RREFLRLQQE NKSNSEALKQ QQQQLAAQHR DSEAHIKHLL
360 370 380 390 400
HQRQRRIEEQ KEERRRVEEQ QRREREQRKM QEKEQQRRLE DMQVMRREEE
410 420 430 440 450
RRQAEREQQQ RREREQRKMQ EKEQQRRLED MQVMRREEER RQAEREQLPS
460 470 480 490 500
LLLGEQQCFY HYNRSANPAE KPTWAREVEE RTRMNKQNAA SPVAKTKLGA
510 520 530 540 550
SESAAPPSSR AESVSLNSSP ASQTPPMQRP VEPQEGQHKS LQDQPTKNMA
560 570 580 590 600
AFPVHDSSSS ASSASSSSAP SPPRAAMIRQ NSDPTSEGPA PQPSRPSAEQ
610 620 630 640 650
RGPWVKMEAE PPPKVPQRTS SIATALNTSG AGGGSSGVGI RPAHAVRARP
660 670 680 690 700
RSRSAWHIHL QSRLERGAKE PPPRRAEPQF PPNSNLDLGR SDPGWERTDT
710 720 730 740 750
LLHSGGAPFP QPGFLERNRV GGPLKLDSSP ILPQGNKAKA AEDHRSRPGR
760 770 780 790 800
PADFFILKSD LLQLATNPPA PQVGNLRASR DRTSVVKDED MGQLSLCPPL
810 820 830 840 850
LTALSSSSSA RDGDTDSVST MVVHDVEDLA GSSGGGGGSG GSESSYGEGT
860 870 880 890 900
MLVQRTPDEE RGLMHSDSNG YTNLPDVVQP SHSPTEAKSS SNGSSSPAKD
910 920 930 940 950
AATDYQSRGL VKPGKSSFTC LWTWASTRAA MGGGDTIPIT VLCFAAFDAG
960 970 980 990 1000
RLEQLQLEAR KGSVVNVNPT NTRPHSDTPE IRKYKKRFNS EILCAALWGV
1010 1020 1030 1040 1050
NLLVGTENGL MLLDRSGQGK VYSLINRRRF QQMDVLEGLN LLTTISGKRN
1060 1070 1080 1090 1100
KLRVYYLSWL RNKILHNDPE VEKKQGWTTV GDMEGCVHYR VVKYERIKFL
1110 1120 1130 1140 1150
VIALKNSVEV YAWAPKPYHK FMAFKSFADL PHRPLLVELT VEEGQRLKVI
1160 1170 1180 1190 1200
YGSCAGFHAI DVDSGNNYDI YIPVHIQSQI TPHAIIFLPN TDGMEVLLCY
1210 1220 1230 1240 1250
EDEGVYVNTY GRIIKDVVLQ WGEMPTSVAY ICSNQIMGWG EKAIEIRSVE
1260 1270 1280 1290 1300
TGHLDGVFMH KRAQRLKFLC ERNDKVGPRA SFPERTLGPV AFPSYQLWSK
1310
ILSLYFTIVS YPE
Length:1,313
Mass (Da):147,808
Last modified:June 26, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAC789C0E578007FA
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAWZ02034569 Genomic DNA No translation available.
AAWZ02034570 Genomic DNA No translation available.
AAWZ02034571 Genomic DNA No translation available.
AAWZ02034572 Genomic DNA No translation available.
AAWZ02034573 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSACAT00000003141; ENSACAP00000003063; ENSACAG00000003068

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAWZ02034569 Genomic DNA No translation available.
AAWZ02034570 Genomic DNA No translation available.
AAWZ02034571 Genomic DNA No translation available.
AAWZ02034572 Genomic DNA No translation available.
AAWZ02034573 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi28377.ENSACAP00000003063

Genome annotation databases

EnsembliENSACAT00000003141; ENSACAP00000003063; ENSACAG00000003068

Phylogenomic databases

eggNOGiKOG0587, Eukaryota
GeneTreeiENSGT00950000183196
HOGENOMiCLU_001831_2_0_1
InParanoidiH9G748
TreeFamiTF105138

Gene expression databases

BgeeiENSACAG00000003068, Expressed in skeletal muscle tissue and 15 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR001180, CNH_dom
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
IPR008271, Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00780, CNH, 1 hit
PF00069, Pkinase, 1 hit
SMARTiView protein in SMART
SM00036, CNH, 1 hit
SM00220, S_TKc, 1 hit
SUPFAMiSSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50219, CNH, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH9G748_ANOCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H9G748
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 16, 2012
Last sequence update: June 26, 2013
Last modified: December 2, 2020
This is version 60 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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