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UniProtKB - H9G6Z9 (H9G6Z9_ANOCA)
Protein
Submitted name:
REL proto-oncogene, NF-kB subunit
Gene
REL
Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Functioni
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: Ensembl
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- I-kappaB kinase/NF-kappaB signaling Source: GO_Central
- inflammatory response Source: GO_Central
- innate immune response Source: GO_Central
- negative regulation of interferon-beta production Source: Ensembl
- NIK/NF-kappaB signaling Source: GO_Central
- positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
- regulation of transcription by RNA polymerase II Source: GO_Central
- response to cytokine Source: GO_Central
Names & Taxonomyi
Protein namesi | Submitted name: REL proto-oncogene, NF-kB subunitImported |
Gene namesi | Name:RELImported |
Organismi | Anolis carolinensis (Green anole) (American chameleon)Imported |
Taxonomic identifieri | 28377 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Iguania › Dactyloidae › Anolis |
Proteomesi |
|
Subcellular locationi
Expressioni
Gene expression databases
Bgeei | ENSACAG00000003030, Expressed in adrenal gland and 5 other tissues |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 162 | RHDInterPro annotationAdd BLAST | 162 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 382 – 404 | DisorderedSequence analysisAdd BLAST | 23 | |
Regioni | 419 – 446 | DisorderedSequence analysisAdd BLAST | 28 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 388 – 404 | Polar residuesSequence analysisAdd BLAST | 17 |
Phylogenomic databases
eggNOGi | ENOG502QQS6, Eukaryota |
GeneTreei | ENSGT00940000158732 |
HOGENOMi | CLU_004343_5_0_1 |
InParanoidi | H9G6Z9 |
OMAi | NCPVNMI |
OrthoDBi | 916931at2759 |
TreeFami | TF325632 |
Family and domain databases
CDDi | cd01177, IPT_NFkappaB, 1 hit |
Gene3Di | 2.60.40.10, 1 hit 2.60.40.340, 1 hit |
InterProi | View protein in InterPro IPR030505, c-Rel IPR013783, Ig-like_fold IPR014756, Ig_E-set IPR002909, IPT_dom IPR033926, IPT_NFkappaB IPR000451, NFkB/Dor IPR008967, p53-like_TF_DNA-bd IPR030492, RHD_CS IPR032397, RHD_dimer IPR011539, RHD_DNA_bind_dom IPR037059, RHD_DNA_bind_dom_sf |
PANTHERi | PTHR24169, PTHR24169, 1 hit PTHR24169:SF4, PTHR24169:SF4, 1 hit |
Pfami | View protein in Pfam PF16179, RHD_dimer, 1 hit PF00554, RHD_DNA_bind, 1 hit |
PRINTSi | PR00057, NFKBTNSCPFCT |
SMARTi | View protein in SMART SM00429, IPT, 1 hit |
SUPFAMi | SSF49417, SSF49417, 1 hit SSF81296, SSF81296, 1 hit |
PROSITEi | View protein in PROSITE PS01204, REL_1, 1 hit PS50254, REL_2, 1 hit |
i Sequence
Sequence statusi: Complete.
H9G6Z9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRFRYKCEGR SAGSIPGEHT TDINRTFPSI QILNYVGKIK IRITLVTKTE
60 70 80 90 100
PYRPHPHRLV GKDCENGYYE AEFGPERRVL IFQNLGIQCV KKRDLKESII
110 120 130 140 150
LRMSKKINPF GVSEDQMLAI DEYDLSVVRL CFQALVCDEH GNCTIPLPPV
160 170 180 190 200
ISNPIYDNRA PKSAELRICR VNKNCGSVKG GDEIFLLCDK VLKDDIEVRF
210 220 230 240 250
VMNDWEAKGV FSQADVHRQV AIVFRTPPFY KDISEPITVQ MQLRRPSDQE
260 270 280 290 300
LSLPMDFRYL PEEKDPYGHK SKKQRMPIVF KKLIKDCGPY EKSKAGSMFQ
310 320 330 340 350
PASSEGKMIK KEGNLYHPQT GSVPMERTSM NTLPAQPYYP PSINNHCSNG
360 370 380 390 400
HHVTMGPIKQ NGVLPSCWRS SGPPFDGFLP EENFSGNMLP PGLQNSGSPS
410 420 430 440 450
LQQEQSLNWV NQKDKNFYRT FTNTRNGPGA SLSSLPSSSP SSTTTQQDLL
460 470 480 490 500
NVSNTVANHP SHSVNVTVAN GLSMEMDDAR CSSVTLEKAS FVQVLNANGH
510 520 530 540 550
GQQVQPIPHH GTSAEAVCNS SLNSMSNAYE PLSFSYLESL SEVRPPSQPA
560 570 580
LQNSVNMSNS QYFSTYSTQD EEFLNAFDAM L
Sequence databases
RefSeqi | XP_003227818.2, XM_003227770.3 XP_016853064.1, XM_016997575.1 |
Genome annotation databases
Ensembli | ENSACAT00000003030; ENSACAP00000002953; ENSACAG00000003030 |
GeneIDi | 100557126 |
KEGGi | acs:100557126 |
Similar proteinsi
Cross-referencesi
Sequence databases
RefSeqi | XP_003227818.2, XM_003227770.3 XP_016853064.1, XM_016997575.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000002953 |
Genome annotation databases
Ensembli | ENSACAT00000003030; ENSACAP00000002953; ENSACAG00000003030 |
GeneIDi | 100557126 |
KEGGi | acs:100557126 |
Organism-specific databases
CTDi | 5966 |
Phylogenomic databases
eggNOGi | ENOG502QQS6, Eukaryota |
GeneTreei | ENSGT00940000158732 |
HOGENOMi | CLU_004343_5_0_1 |
InParanoidi | H9G6Z9 |
OMAi | NCPVNMI |
OrthoDBi | 916931at2759 |
TreeFami | TF325632 |
Gene expression databases
Bgeei | ENSACAG00000003030, Expressed in adrenal gland and 5 other tissues |
Family and domain databases
CDDi | cd01177, IPT_NFkappaB, 1 hit |
Gene3Di | 2.60.40.10, 1 hit 2.60.40.340, 1 hit |
InterProi | View protein in InterPro IPR030505, c-Rel IPR013783, Ig-like_fold IPR014756, Ig_E-set IPR002909, IPT_dom IPR033926, IPT_NFkappaB IPR000451, NFkB/Dor IPR008967, p53-like_TF_DNA-bd IPR030492, RHD_CS IPR032397, RHD_dimer IPR011539, RHD_DNA_bind_dom IPR037059, RHD_DNA_bind_dom_sf |
PANTHERi | PTHR24169, PTHR24169, 1 hit PTHR24169:SF4, PTHR24169:SF4, 1 hit |
Pfami | View protein in Pfam PF16179, RHD_dimer, 1 hit PF00554, RHD_DNA_bind, 1 hit |
PRINTSi | PR00057, NFKBTNSCPFCT |
SMARTi | View protein in SMART SM00429, IPT, 1 hit |
SUPFAMi | SSF49417, SSF49417, 1 hit SSF81296, SSF81296, 1 hit |
PROSITEi | View protein in PROSITE PS01204, REL_1, 1 hit PS50254, REL_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | H9G6Z9_ANOCA | |
Accessioni | H9G6Z9Primary (citable) accession number: H9G6Z9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 16, 2012 |
Last sequence update: | June 26, 2013 | |
Last modified: | September 29, 2021 | |
This is version 57 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |