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Entry version 39 (19 Jan 2022)
Sequence version 1 (16 May 2012)
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Protein
Submitted name:

Ankyrin-2 isoform 2

Gene

ANK2

Organism
Macaca mulatta (Rhesus macaque)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Ankyrin-2 isoform 2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ANK2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMacaca mulatta (Rhesus macaque)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9544 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, CytoskeletonARBA annotation

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati63 – 95ANKPROSITE-ProRule annotationAdd BLAST33
Repeati96 – 128ANKPROSITE-ProRule annotationAdd BLAST33
Repeati129 – 161ANKPROSITE-ProRule annotationAdd BLAST33
Repeati232 – 264ANKPROSITE-ProRule annotationAdd BLAST33
Repeati265 – 297ANKPROSITE-ProRule annotationAdd BLAST33
Repeati298 – 330ANKPROSITE-ProRule annotationAdd BLAST33
Repeati331 – 363ANKPROSITE-ProRule annotationAdd BLAST33
Repeati364 – 396ANKPROSITE-ProRule annotationAdd BLAST33
Repeati397 – 429ANKPROSITE-ProRule annotationAdd BLAST33
Repeati430 – 462ANKPROSITE-ProRule annotationAdd BLAST33
Repeati463 – 495ANKPROSITE-ProRule annotationAdd BLAST33
Repeati496 – 528ANKPROSITE-ProRule annotationAdd BLAST33
Repeati529 – 561ANKPROSITE-ProRule annotationAdd BLAST33
Repeati562 – 594ANKPROSITE-ProRule annotationAdd BLAST33
Repeati595 – 627ANKPROSITE-ProRule annotationAdd BLAST33
Repeati628 – 660ANKPROSITE-ProRule annotationAdd BLAST33
Repeati661 – 693ANKPROSITE-ProRule annotationAdd BLAST33
Repeati694 – 726ANKPROSITE-ProRule annotationAdd BLAST33
Repeati727 – 759ANKPROSITE-ProRule annotationAdd BLAST33
Repeati760 – 792ANKPROSITE-ProRule annotationAdd BLAST33
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini980 – 1168ZU5InterPro annotationAdd BLAST189
Domaini1170 – 1316ZU5InterPro annotationAdd BLAST147
Domaini1496 – 1580DeathInterPro annotationAdd BLAST85

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 34DisorderedSequence analysisAdd BLAST34
Regioni1470 – 1494DisorderedSequence analysisAdd BLAST25
Regioni1653 – 1680DisorderedSequence analysisAdd BLAST28
Regioni1703 – 1806DisorderedSequence analysisAdd BLAST104
Regioni1839 – 1860DisorderedSequence analysisAdd BLAST22

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi8 – 31Basic and acidic residuesSequence analysisAdd BLAST24
Compositional biasi1703 – 1727Polar residuesSequence analysisAdd BLAST25
Compositional biasi1736 – 1750Polar residuesSequence analysisAdd BLAST15
Compositional biasi1756 – 1770Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi1781 – 1804Basic and acidic residuesSequence analysisAdd BLAST24

Keywords - Domaini

ANK repeatPROSITE-ProRule annotation

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.533.10, 1 hit
1.25.40.20, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110, Ankyrin_rpt
IPR036770, Ankyrin_rpt-contain_sf
IPR040745, Ankyrin_UPA
IPR011029, DEATH-like_dom_sf
IPR000488, Death_domain
IPR000906, ZU5_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00023, Ank, 1 hit
PF12796, Ank_2, 7 hits
PF13637, Ank_4, 2 hits
PF00531, Death, 1 hit
PF17809, UPA_2, 1 hit
PF00791, ZU5, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01415, ANKYRIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248, ANK, 23 hits
SM00005, DEATH, 1 hit
SM00218, ZU5, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47986, SSF47986, 1 hit
SSF48403, SSF48403, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50088, ANK_REPEAT, 20 hits
PS50017, DEATH_DOMAIN, 1 hit
PS51145, ZU5, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

H9FTB9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMNEDAAQKS DSGEKFNGSS QRRKRPKKSD SNASFLRAAR AGNLDKVVEY
60 70 80 90 100
LKGGIDINTC NQNGLNALHL AAKEGHVGLV QELLGRGSSV DSATKKGNTA
110 120 130 140 150
LHIASLAGQA EVVKVLVKEG ANINAQSQNG FTPLYMAAQE NHIDVVKYLL
160 170 180 190 200
ENGANQSTAT EDGFTPLAVA LQQGHNQAVA ILLENDTKGK VRLPALHIAA
210 220 230 240 250
RKDDTKSAAL LLQNDHNADV QSKMMVNRTT ESGFTPLHIA AHYGNVNVAT
260 270 280 290 300
LLLNRGAAVD FTARNGITPL HVASKRGNTN MVKLLLDRGG QIDAKTRDGL
310 320 330 340 350
TPLHCAARSG HDQVVELLLE RGAPLLARTK NGLSPLHMAA QGDHVECVKH
360 370 380 390 400
LLQHKAPVDD VTLDYLTALH VAAHCGHYRV TKLLLDKRAN PNARALNGFT
410 420 430 440 450
PLHIACKKNR IKVMELLVKY GASIQAITES GLTPIHVAAF MGHLNIVLLL
460 470 480 490 500
LQNGASPDVT NIRGETALHM AARAGQVEVV RCLLRNGALV DARAREEQTP
510 520 530 540 550
LHIASRLGKT EIVQLLLQHM AHPDAATTNG YTPLHISARE GQVDVASVLL
560 570 580 590 600
EAGAAHSLAT KKGFTPLHVA AKYGSLDVAK LLLQRRAAAD SAGKNGLTPL
610 620 630 640 650
HVAAHYDNQK VALLLLEKGA SPHATAKNGY TPLHIAAKKN QMQIASTLLN
660 670 680 690 700
YGAETNIVTK QGVTPLHLAS QEGHTDMVTL LLDKGANIHM STKSGLTSLH
710 720 730 740 750
LAAQEDKVNV ADILTKHGAD QDAHTKLGYT PLIVACHYGN VKMVNFLLKQ
760 770 780 790 800
GANVNAKTKN GYTPLHQAAQ QGHTHIINVL LQHGAKPNAT TANGNTALAI
810 820 830 840 850
AKRLGYISVV DTLKVVTEEV TTTTTTITEK HKLNVPETMT EVLDVSDEEG
860 870 880 890 900
DDTMTGDGGE YLRPEDLKEL GDDSLPSSQF LDGMNYLRYS LEGGRSDSLR
910 920 930 940 950
SFSSDRSHTL SHASYLRDSA VMDDSVVIPS HQVSTLAKEA ERNSYRLSWG
960 970 980 990 1000
TENLDNVALS SSPIHSGRAS PCLDRDNSSF LVSFMVDARG GAMRGCRHNG
1010 1020 1030 1040 1050
LRIIIPPRKC TAPTRVTCRL VKRHRLATMP PMVEGEGLAS RLIEVGPSGA
1060 1070 1080 1090 1100
QFLGKLHLPT APPPLNEGES LVSRILQLGP PGTKFLGPVI VEIPHFAALR
1110 1120 1130 1140 1150
GKERELVVLR SENGDSWKEH FCDYTEDELN EILNGMDEVL DSPEDLEKKR
1160 1170 1180 1190 1200
ICRIITRDFP QYFAVVSRIK QDSNLIGPEG GVLSSTVVPQ VQAVFPEGAL
1210 1220 1230 1240 1250
TKRIRVGLQA QPMHTELVKK ILGNKATFSP IVTLEPRRRK FHKPITMTIP
1260 1270 1280 1290 1300
VPKASSDVML NGFGGDAPTL RLLCSITGGT TPAQWEDITG TTPLTFVNEC
1310 1320 1330 1340 1350
VSFTTNVSAR FWLIDCRQIQ ESVTFASQVY REIICVPYMA KFVVFAKSHD
1360 1370 1380 1390 1400
PIEARLRCFC MTDDKVDKTL EQQENFAEVA RSRDVEVLEG KPIYVDCFGN
1410 1420 1430 1440 1450
LVPLTKSGQH HIFSFFAFKE NRLPLFVKVR DTTQEPCGRL SFMKEPKSTR
1460 1470 1480 1490 1500
GLVHQAICNL NITLPIYTKE SESDQEQEEE IDMTSEKNPQ DEQERIEERL
1510 1520 1530 1540 1550
AYIADHLGFS WTELARELDF TEEQIHQIRI ENPNSLQDQS HALLKYWLER
1560 1570 1580 1590 1600
DGKHATDTNL IECLTKINRM DIVHLMETNM EPLQERISHS YAEIEQTITL
1610 1620 1630 1640 1650
DHSEGFSVLQ EELCTAQHKQ KEEQALSKES ETCDHPPIVS EEDISVGYST
1660 1670 1680 1690 1700
FQDGIPKTEG DSSATALFPQ THKEQVQQDF SGKMQDLPEE SSLEYRQEYF
1710 1720 1730 1740 1750
VTTPGTEASE TQKATTVPGS PSKTPEEVST PPEEDRLYLQ TPTSSERGGS
1760 1770 1780 1790 1800
PIIQEPEEPS EHREESSPRK TSLVIVESAD NQPETRERLD EDAAFEKGDD
1810 1820 1830 1840 1850
MPEIPPETVT EEEYIDEHGH TVVKKVTRKI IRRYVSSEGT EKEEITVQGM
1860 1870 1880
PQEPVNIEEG DGYSKVIKRV VLKSDIEQSE DNNE
Length:1,884
Mass (Da):207,184
Last modified:May 16, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i272BDB6D23DCB02D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
JU334120 mRNA Translation: AFE77875.1
JU334122 mRNA Translation: AFE77877.1
JU334123 mRNA Translation: AFE77878.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JU334120 mRNA Translation: AFE77875.1
JU334122 mRNA Translation: AFE77877.1
JU334123 mRNA Translation: AFE77878.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Family and domain databases

Gene3Di1.10.533.10, 1 hit
1.25.40.20, 3 hits
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR036770, Ankyrin_rpt-contain_sf
IPR040745, Ankyrin_UPA
IPR011029, DEATH-like_dom_sf
IPR000488, Death_domain
IPR000906, ZU5_dom
PfamiView protein in Pfam
PF00023, Ank, 1 hit
PF12796, Ank_2, 7 hits
PF13637, Ank_4, 2 hits
PF00531, Death, 1 hit
PF17809, UPA_2, 1 hit
PF00791, ZU5, 2 hits
PRINTSiPR01415, ANKYRIN
SMARTiView protein in SMART
SM00248, ANK, 23 hits
SM00005, DEATH, 1 hit
SM00218, ZU5, 1 hit
SUPFAMiSSF47986, SSF47986, 1 hit
SSF48403, SSF48403, 3 hits
PROSITEiView protein in PROSITE
PS50088, ANK_REPEAT, 20 hits
PS50017, DEATH_DOMAIN, 1 hit
PS51145, ZU5, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH9FTB9_MACMU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H9FTB9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 16, 2012
Last sequence update: May 16, 2012
Last modified: January 19, 2022
This is version 39 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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