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Entry version 40 (02 Jun 2021)
Sequence version 1 (16 May 2012)
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Protein

Tudor domain-containing protein 7

Gene

TDRD7

Organism
Macaca mulatta (Rhesus macaque)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-bindingARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tudor domain-containing protein 7ARBA annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TDRD7Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMacaca mulatta (Rhesus macaque)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9544 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006718 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:79886, TDRD7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

CytoplasmARBA annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMMUG00000012275, Expressed in spermatocyte and 26 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9544.ENSMMUP00000016104

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini3 – 76HTH OST-typeInterPro annotationAdd BLAST74
Domaini233 – 302HTH OST-typeInterPro annotationAdd BLAST70
Domaini337 – 406HTH OST-typeInterPro annotationAdd BLAST70
Domaini513 – 570TudorInterPro annotationAdd BLAST58
Domaini703 – 760TudorInterPro annotationAdd BLAST58

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni129 – 154DisorderedSequence analysisAdd BLAST26

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TDRD7 family.ARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2039, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00890000139482

Identification of Orthologs from Complete Genome Data

More...
OMAi
MDVYVSV

Database of Orthologous Groups

More...
OrthoDBi
1276848at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd09974, LOTUS_3_TDRD7, 1 hit
cd04508, TUDOR, 3 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.1880, 3 hits
2.40.50.90, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR041966, LOTUS-like
IPR025605, OST-HTH/LOTUS_dom
IPR035437, SNase_OB-fold_sf
IPR037978, TDRD7_LOTUS_3
IPR002999, Tudor

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12872, OST-HTH, 2 hits
PF00567, TUDOR, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00333, TUDOR, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51644, HTH_OST, 3 hits
PS50304, TUDOR, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

H9EVV9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLEGDLVSKM LRAVLQSHKN GVALPRLQGE YRSLTGDWIP FKQLGFPTLE
60 70 80 90 100
AYLRSVPAVV RIETSRSGEI TCYAMACTET ARIAQLVARQ RSSKRKTGRQ
110 120 130 140 150
VNCQMRVKKT MPFFLEGKPK ATLRQPGFAS NFSVGKKPNP APLRDKGNSA
160 170 180 190 200
GVKPEAEMSP YMLHTTLGNE ALKDTPVQRH VTMSTNNRFS PKASLQPPLQ
210 220 230 240 250
IHLSRTSTKE MSDNLNQTVE KPNVTPPASY TYKMDEVQNR IKEILNKHNN
260 270 280 290 300
GIWISKLPHF YKELYKEDLN QGILQQFEHW PHICTVEKPC SGGQDLLLYP
310 320 330 340 350
AKRKQLLRSE LDTEKVPPSP LPAPKQTPPL KGCPTVVAGD FKEKVAELLV
360 370 380 390 400
KYTSGLWASA LPKAFEEMYK VKFPEDALKN LSSLSDVCTI DYISGNPQKA
410 420 430 440 450
ILYAKLPLPA DKIQTDAGQA HGDHDIKAMV EQEYLQIEEN IAESANTFME
460 470 480 490 500
DITVPPLMIP TEASPSVLVV ELSNTNEVVI RYVGKDYSAA QELMEDEMKE
510 520 530 540 550
YYSKNPKVIP VQAVNVGQLL AVNAEEDAWL RAQVISTEEN KIKVCYVDYG
560 570 580 590 600
FSENVEKNKA YKLNPKFCSL SFQATKCKLA GLEVLSDDPD LVKVVESLTC
610 620 630 640 650
GKIFAVEILD KADIPLVVLY DTSGEDDINI NATCLKAICD KSLEVHLQVD
660 670 680 690 700
AMYTNVKVTN ICSDGTLYCQ VPCKGLNKLN DLLHKIEDYF HCKHMTSECF
710 720 730 740 750
VSLPFCGKIC LFHCKGKWLR VEITNVHSSR ALDVQFLDSG TVTSVKVSEL
760 770 780 790 800
REIPPRFLQE MIAIPPQAIK CCLADLPQSI GMWTPDAVLW LRDSVLNCSD
810 820 830 840 850
CSIKVTKVDE TRGIAHVYLF TPKNFPDPHR SINRQITNAD LWKHQKDVFL
860 870 880 890 900
SAISSGAGSP DSKNGNMPML GNTGENFRKN LTDVIKKSMV DHTSSFSTEE
910 920 930 940 950
LPPPVHLSKP GEHMDVYVPV ACHPGYFVIQ PWQEIHKLEV LMEEMILYYS
960 970 980 990 1000
VSEERHIAVE KDQVYAAKVE NKWHRVLLKG ILTNGLVSVY ELDYGKHELV
1010 1020 1030 1040 1050
NIRKVQPLVD MFRKLPFQAV TAQLAGVKCN QWSEEASMVF RNHVEKKPLV
1060 1070 1080 1090
ALVQTVIENA NPWDRKVVVY LVDTSLPDTD IWIHDFMSEY LIELSKVN
Length:1,098
Mass (Da):123,527
Last modified:May 16, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEE3614D3C14EE2AC
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
JU322762 mRNA Translation: AFE66518.1
JU473819 mRNA Translation: AFH30623.1

NCBI Reference Sequences

More...
RefSeqi
NP_001181558.1, NM_001194629.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMMUT00000017195; ENSMMUP00000016104; ENSMMUG00000012275

Database of genes from NCBI RefSeq genomes

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GeneIDi
641450

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mcc:641450

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JU322762 mRNA Translation: AFE66518.1
JU473819 mRNA Translation: AFH30623.1
RefSeqiNP_001181558.1, NM_001194629.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000016104

Genome annotation databases

EnsembliENSMMUT00000017195; ENSMMUP00000016104; ENSMMUG00000012275
GeneIDi641450
KEGGimcc:641450

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23424
VGNCiVGNC:79886, TDRD7

Phylogenomic databases

eggNOGiKOG2039, Eukaryota
GeneTreeiENSGT00890000139482
OMAiMDVYVSV
OrthoDBi1276848at2759

Gene expression databases

BgeeiENSMMUG00000012275, Expressed in spermatocyte and 26 other tissues

Family and domain databases

CDDicd09974, LOTUS_3_TDRD7, 1 hit
cd04508, TUDOR, 3 hits
Gene3Di1.10.10.1880, 3 hits
2.40.50.90, 3 hits
InterProiView protein in InterPro
IPR041966, LOTUS-like
IPR025605, OST-HTH/LOTUS_dom
IPR035437, SNase_OB-fold_sf
IPR037978, TDRD7_LOTUS_3
IPR002999, Tudor
PfamiView protein in Pfam
PF12872, OST-HTH, 2 hits
PF00567, TUDOR, 3 hits
SMARTiView protein in SMART
SM00333, TUDOR, 2 hits
PROSITEiView protein in PROSITE
PS51644, HTH_OST, 3 hits
PS50304, TUDOR, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH9EVV9_MACMU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H9EVV9
Secondary accession number(s): F7DS66
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 16, 2012
Last sequence update: May 16, 2012
Last modified: June 2, 2021
This is version 40 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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