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Protein

Cytochrome c oxidase subunit 2

Gene

COX2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.UniRule annotation

GO - Molecular functioni

Keywordsi

Biological processElectron transport, Respiratory chainUniRule annotationSAAS annotation, Transport
LigandCopperUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2UniRule annotationSAAS annotation
Gene namesi
Name:COX2Imported
Encoded oniMitochondrionImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei26 – 45HelicalSequence analysisAdd BLAST20
Transmembranei65 – 84HelicalSequence analysisAdd BLAST20

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membraneUniRule annotationSAAS annotation

PTM / Processingi

Proteomic databases

PeptideAtlasiH9E7T7
PRIDEiH9E7T7

Structurei

3D structure databases

SMRiH9E7T7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 90COX2_TMInterPro annotationAdd BLAST90
Domaini91 – 224COX2_CUAInterPro annotationAdd BLAST134

Sequence similaritiesi

Belongs to the cytochrome c oxidase subunit 2 family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG4767 Eukaryota
COG1622 LUCA
OMAiWSYEYTD

Family and domain databases

CDDicd13912 CcO_II_C, 1 hit
Gene3Di1.10.287.90, 1 hit
2.60.40.420, 1 hit
InterProiView protein in InterPro
IPR002429 CcO_II-like_C
IPR034210 CcO_II_C
IPR001505 Copper_CuA
IPR008972 Cupredoxin
IPR014222 Cyt_c_oxidase_su2
IPR011759 Cyt_c_oxidase_su2_TM_dom
IPR036257 Cyt_c_oxidase_su2_TM_sf
PfamiView protein in Pfam
PF00116 COX2, 1 hit
PF02790 COX2_TM, 1 hit
SUPFAMiSSF49503 SSF49503, 1 hit
SSF81464 SSF81464, 1 hit
TIGRFAMsiTIGR02866 CoxB, 1 hit
PROSITEiView protein in PROSITE
PS00078 COX2, 1 hit
PS50857 COX2_CUA, 1 hit
PS50999 COX2_TM, 1 hit

Sequencei

Sequence statusi: Fragment.

H9E7T7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
AHAAQVGLQD ATSPIMEELI TFHDHALMII FLICFLVLYA LFLTLTTKLT
60 70 80 90 100
NTNISDAQEM ETVWTILPAI ILVLIALPSL RILYMTDEVN DPSLTIKSIG
110 120 130 140 150
HQWYWTYEYT DYGGLIFNSY MLPPLFLEPG DLRLLDVDNR VVLPIEAPIR
160 170 180 190 200
MMITSQDVLH SWAVPTLGLK TDAIPGRLNQ TTFTATRPGV YYGQCSEICG
210 220
ANHSFMPIVL ELIPLKIFEM GPVFTL
Length:226
Mass (Da):25,434
Last modified:May 16, 2012 - v1
Checksum:i47775D4F1B41EEB5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JQ664518 Genomic DNA Translation: AFC97781.1
JQ664526 Genomic DNA Translation: AFC97885.1

Similar proteinsi

Entry informationi

Entry nameiH9E7T7_HUMAN
AccessioniPrimary (citable) accession number: H9E7T7
Entry historyiIntegrated into UniProtKB/TrEMBL: May 16, 2012
Last sequence update: May 16, 2012
Last modified: May 23, 2018
This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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