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Protein

Isocitrate dehydrogenase [NADP]

Gene

HPELS_00125

Organism
Helicobacter pylori ELS37
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processGlyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation
LigandManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciHPYL1055527:G1H4F-30-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
ORF Names:HPELS_00125Imported
OrganismiHelicobacter pylori ELS37Imported
Taxonomic identifieri1055527 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000007885 Componenti: Chromosome

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 421Iso_dhInterPro annotationAdd BLAST391

Phylogenomic databases

KOiK00031

Family and domain databases

InterProiView protein in InterPro
IPR019818 IsoCit/isopropylmalate_DH_CS
IPR004439 Isocitrate_DH_NADP_dimer_prok
IPR024084 IsoPropMal-DH-like_dom
PANTHERiPTHR43504 PTHR43504, 1 hit
PfamiView protein in Pfam
PF00180 Iso_dh, 1 hit
SMARTiView protein in SMART
SM01329 Iso_dh, 1 hit
TIGRFAMsiTIGR00183 prok_nadp_idh, 1 hit
PROSITEiView protein in PROSITE
PS00470 IDH_IMDH, 1 hit

Sequencei

Sequence statusi: Complete.

H8H6L2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAYNPKILQK PKEGEEITIK DNKLHVPNHP IIPFIEGDGI GSDITPAMIK
60 70 80 90 100
VVDSAVQKAY KGEKKIAWYE VFVGEKCYQK FKDHKELSPE EQWLLPDTIE
110 120 130 140 150
AINHYKVSIK GPLTTPIGEG FRSLNVALRQ KMDLYVCLRP VRWYGSPSPV
160 170 180 190 200
KEPQKVDMVI FRENSEDIYA GIEWQEGSAE AKKLIHFLQN ELKVKKIRFP
210 220 230 240 250
ESSGVGIKPI SKEGTERLVR KAIEYAIDND KPSVTFVHKG NIMKYTEGAF
260 270 280 290 300
MKWGYALAQK EFNAQVIDKG PWCSLKNPKT GKEIIIKDMI ADAFLQQILL
310 320 330 340 350
RPSEYSVIAT MNLNGDYVSD ALAAMVGGIG IAPGANLNDT VGMFEATHGT
360 370 380 390 400
APKYAGLDKV NPGSIILSAE MMLRHMGWVE AADLIVSAME KAIKSKKVTY
410 420
DFARLMDGAK EVKCSEFASV MIENM
Length:425
Mass (Da):47,478
Last modified:May 16, 2012 - v1
Checksum:i582BAE84B00CE74A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002953 Genomic DNA Translation: AFF19613.1
RefSeqiWP_000323974.1, NC_017063.1

Genome annotation databases

EnsemblBacteriaiAFF19613; AFF19613; HPELS_00125
KEGGihpe:HPELS_00125
PATRICifig|1055527.3.peg.25

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002953 Genomic DNA Translation: AFF19613.1
RefSeqiWP_000323974.1, NC_017063.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAFF19613; AFF19613; HPELS_00125
KEGGihpe:HPELS_00125
PATRICifig|1055527.3.peg.25

Phylogenomic databases

KOiK00031

Enzyme and pathway databases

BioCyciHPYL1055527:G1H4F-30-MONOMER

Family and domain databases

InterProiView protein in InterPro
IPR019818 IsoCit/isopropylmalate_DH_CS
IPR004439 Isocitrate_DH_NADP_dimer_prok
IPR024084 IsoPropMal-DH-like_dom
PANTHERiPTHR43504 PTHR43504, 1 hit
PfamiView protein in Pfam
PF00180 Iso_dh, 1 hit
SMARTiView protein in SMART
SM01329 Iso_dh, 1 hit
TIGRFAMsiTIGR00183 prok_nadp_idh, 1 hit
PROSITEiView protein in PROSITE
PS00470 IDH_IMDH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiH8H6L2_HELPX
AccessioniPrimary (citable) accession number: H8H6L2
Entry historyiIntegrated into UniProtKB/TrEMBL: May 16, 2012
Last sequence update: May 16, 2012
Last modified: February 28, 2018
This is version 31 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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