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Protein

Ferritin BfrB

Gene

bfrB

Organism
Mycobacterium tuberculosis (strain ATCC 35801 / TMC 107 / Erdman)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Iron-storage protein that displays ferroxidase activity, catalyzing the oxidation of Fe2+ ions into Fe3+ ions, that can then be deposited as a ferric-oxide mineral core within the central cavity of the protein complex.By similarity

Catalytic activityi

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi22Iron 1PROSITE-ProRule annotation1
Metal bindingi55Iron 1PROSITE-ProRule annotation1
Metal bindingi55Iron 2PROSITE-ProRule annotation1
Metal bindingi58Iron 1PROSITE-ProRule annotation1
Metal bindingi99Iron 2PROSITE-ProRule annotation1
Metal bindingi132Iron 2PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processIron storage
LigandIron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ferritin BfrB (EC:1.16.3.1)
Alternative name(s):
Bacterioferritin
Non-heme ferritin Ftn
Nox19
Gene namesi
Name:bfrB
Ordered Locus Names:ERDMAN_4208
OrganismiMycobacterium tuberculosis (strain ATCC 35801 / TMC 107 / Erdman)
Taxonomic identifieri652616 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000007568 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004226871 – 181Ferritin BfrBAdd BLAST181

Expressioni

Inductioni

Repressed by Rip1, highly induced by metal chelator phenanthroline in the absence of Rip1.1 Publication

Interactioni

Subunit structurei

Homooligomer of 24 subunits that are packed together to form an approximately spherical molecule with a central cavity, in which large amounts of iron can be stored.By similarity

Structurei

3D structure databases

ProteinModelPortaliH8F1Z2
SMRiH8F1Z2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 150Ferritin-like diironPROSITE-ProRule annotationAdd BLAST136

Sequence similaritiesi

Belongs to the ferritin family. Prokaryotic subfamily.Curated

Phylogenomic databases

KOiK22336
OrthoDBiPOG091H049F

Family and domain databases

Gene3Di1.20.1260.10, 1 hit
InterProiView protein in InterPro
IPR001519 Ferritin
IPR012347 Ferritin-like
IPR009040 Ferritin-like_diiron
IPR009078 Ferritin-like_SF
IPR008331 Ferritin_DPS_dom
PANTHERiPTHR11431 PTHR11431, 1 hit
PfamiView protein in Pfam
PF00210 Ferritin, 1 hit
SUPFAMiSSF47240 SSF47240, 1 hit
PROSITEiView protein in PROSITE
PS50905 FERRITIN_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

H8F1Z2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEYEGPKTK FHALMQEQIH NEFTAAQQYV AIAVYFDSED LPQLAKHFYS
60 70 80 90 100
QAVEERNHAM MLVQHLLDRD LRVEIPGVDT VRNQFDRPRE ALALALDQER
110 120 130 140 150
TVTDQVGRLT AVARDEGDFL GEQFMQWFLQ EQIEEVALMA TLVRVADRAG
160 170 180
ANLFELENFV AREVDVAPAA SGAPHAAGGR L
Length:181
Mass (Da):20,442
Last modified:June 26, 2013 - v2
Checksum:iC0F375669A292F55
GO

Sequence cautioni

The sequence BAL67972 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP012340 Genomic DNA Translation: BAL67972.1 Different initiation.
RefSeqiWP_003420920.1, NZ_KK339488.1

Genome annotation databases

EnsemblBacteriaiBAL67972; BAL67972; ERDMAN_4208
KEGGimtn:ERDMAN_4208
PATRICifig|652616.3.peg.4283

Similar proteinsi

Entry informationi

Entry nameiBFRB_MYCTE
AccessioniPrimary (citable) accession number: H8F1Z2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2013
Last sequence update: June 26, 2013
Last modified: February 28, 2018
This is version 29 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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