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Protein

6-carboxyhexanoate--CoA ligase

Gene

bioW

Organism
Treponema saccharophilum DSM 2985
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the transformation of pimelate into pimeloyl-CoA with concomitant hydrolysis of ATP to AMP.UniRule annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

ATP + 6-carboxyhexanoate + CoA = AMP + diphosphate + 6-carboxyhexanoyl-CoA.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi: pimeloyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes pimeloyl-CoA from pimelate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. 6-carboxyhexanoate--CoA ligase (bioW)
This subpathway is part of the pathway pimeloyl-CoA biosynthesis, which is itself part of Metabolic intermediate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pimeloyl-CoA from pimelate, the pathway pimeloyl-CoA biosynthesis and in Metabolic intermediate metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationImported
Biological processBiotin biosynthesisUniRule annotation
LigandATP-bindingUniRule annotation, MagnesiumUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00999; UER00351

Names & Taxonomyi

Protein namesi
Recommended name:
6-carboxyhexanoate--CoA ligaseUniRule annotation (EC:6.2.1.14UniRule annotation)
Alternative name(s):
Pimeloyl-CoA synthaseUniRule annotation
Gene namesi
Name:bioWUniRule annotation
ORF Names:TresaDRAFT_2069Imported
OrganismiTreponema saccharophilum DSM 2985Imported
Taxonomic identifieri907348 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema
Proteomesi
  • UP000003571 Componenti: Unassembled WGS sequence

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the BioW family.UniRule annotation

Phylogenomic databases

OrthoDBiPOG091H01V4

Family and domain databases

HAMAPiMF_00668 BioW, 1 hit
InterProiView protein in InterPro
IPR005499 BioW
PfamiView protein in Pfam
PF03744 BioW, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD017229 BioW, 1 hit
TIGRFAMsiTIGR01204 bioW, 1 hit

Sequencei

Sequence statusi: Complete.

H7EIX0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSSLGGKNG VGGKHISGAE RIVKSCDVEK TVSSLLKRAR NHERGKADFI
60 70 80 90 100
NLKIQEVNEN EAVRVPLLKI TSKKTSSKSE GRSFAKSELL RIGVSENAVK
110 120 130 140 150
NAFEALESLS DSLRGAIVLD ADSGERLDSF GMRGVRCSNM DVADKDEYEK
160 170 180 190 200
KLSELGMAGE HAREALVLAS KVAHAKGAVA ELCWSDDPNY VTGYVASQKF
210 220 230 240
GYTRISVMKD LGDYVGGRVF FVRLPIDLDY YIDYLQNQVV LVEV
Length:244
Mass (Da):26,783
Last modified:May 16, 2012 - v1
Checksum:iE97B693912F8C10A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AGRW01000039 Genomic DNA Translation: EIC02427.1
RefSeqiWP_002703083.1, NZ_AGRW01000039.1

Genome annotation databases

EnsemblBacteriaiEIC02427; EIC02427; TresaDRAFT_2069
PATRICifig|907348.3.peg.781

Similar proteinsi

Entry informationi

Entry nameiH7EIX0_9SPIO
AccessioniPrimary (citable) accession number: H7EIX0
Entry historyiIntegrated into UniProtKB/TrEMBL: May 16, 2012
Last sequence update: May 16, 2012
Last modified: June 20, 2018
This is version 23 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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