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Protein
Submitted name:

Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

Gene

ATP2A2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionHydrolaseSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2Imported
Gene namesi
Name:ATP2A2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000174437.16
HGNCiHGNC:812 ATP2A2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei6 – 25HelicalSequence analysisAdd BLAST20
Transmembranei151 – 171HelicalSequence analysisAdd BLAST21
Transmembranei183 – 212HelicalSequence analysisAdd BLAST30
Transmembranei650 – 673HelicalSequence analysisAdd BLAST24
Transmembranei724 – 747HelicalSequence analysisAdd BLAST24
Transmembranei821 – 840HelicalSequence analysisAdd BLAST20
Transmembranei904 – 922HelicalSequence analysisAdd BLAST19

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000174437

PTM / Processingi

Proteomic databases

MaxQBiH7C5W9
PeptideAtlasiH7C5W9
PRIDEiH7C5W9

Expressioni

Gene expression databases

BgeeiENSG00000174437 Expressed in 244 organ(s), highest expression level in heart
ExpressionAtlasiH7C5W9 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliH7C5W9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini674 – 877Cation_ATPase_CInterPro annotationAdd BLAST204

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG0202 Eukaryota
COG0474 LUCA
GeneTreeiENSGT00890000139334

Family and domain databases

Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 2 hits
InterProiView protein in InterPro
IPR006068 ATPase_P-typ_cation-transptr_C
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR005782 P-type_ATPase_IIA
IPR001757 P_typ_ATPase
PfamiView protein in Pfam
PF00689 Cation_ATPase_C, 1 hit
PRINTSiPR00120 HATPASE
SUPFAMiSSF56784 SSF56784, 1 hit
SSF81653 SSF81653, 1 hit
SSF81660 SSF81660, 1 hit
SSF81665 SSF81665, 3 hits
TIGRFAMsiTIGR01116 ATPase-IIA1_Ca, 1 hit
TIGR01494 ATPase_P-type, 2 hits
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

H7C5W9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
XTITAFVEPF VILLILVANA IVGVWQERNA ENAIEALKEY EPEMGKVYRQ
60 70 80 90 100
DRKSVQRIKA KDIVPGDIVE IAGESVSVIK HTDPVPDPRA VNQDKKNMLF
110 120 130 140 150
SGTNIAAGKA MGVVVATGVN TEIGKIRDEM VATEQERTPL QQKLDEFGEQ
160 170 180 190 200
LSKVISLICI AVWIINIGHF NDPVHGGSWI RGAIYYFKIA VALAVAAIPE
210 220 230 240 250
GLPAVITTCL ALGTRRMAKK NAIVRSLPSV ETLGCTSVIC SDKTGTLTTN
260 270 280 290 300
QMSVCRMFIL DRVEGDTCSL NEFTITGSTY APIGEVHKDD KPVNCHQYDG
310 320 330 340 350
LVELATICAL CNDSALDYNE AKGVYEKVGE ATETALTCLV EKMNVFDTEL
360 370 380 390 400
KGLSKIERAN ACNSVIKQLM KKEFTLEFSR DRKSMSVYCT PNKPSRTSMS
410 420 430 440 450
KMFVKGAPEG VIDRCTHIRV GSTKVPMTSG VKQKIMSVIR EWGSGSDTLR
460 470 480 490 500
CLALATHDNP LRREEMHLED SANFIKYETN LTFVGCVGML DPPRIEVASS
510 520 530 540 550
VKLCRQAGIR VIMITGDNKG TAVAICRRIG IFGQDEDVTS KAFTGREFDE
560 570 580 590 600
LNPSAQRDAC LNARCFARVE PSHKSKIVEF LQSFDEITAM TGDGVNDAPA
610 620 630 640 650
LKKAEIGIAM GSGTAVAKTA SEMVLADDNF STIVAAVEEG RAIYNNMKQF
660 670 680 690 700
IRYLISSNVG EVVCIFLTAA LGFPEALIPV QLLWVNLVTD GLPATALGFN
710 720 730 740 750
PPDLDIMNKP PRNPKEPLIS GWLFFRYLAI GCYVGAATVG AAAWWFIAAD
760 770 780 790 800
GGPRVSFYQL SHFLQCKEDN PDFEGVDCAI FESPYPMTMA LSVLVTIEMC
810 820 830 840 850
NALNSLSENQ SLLRMPPWEN IWLVGSICLS MSLHFLILYV EPLPLIFQIT
860 870 880 890 900
PLNVTQWLMV LKISLPVILM DETLKFVARN YLEPGKECVQ PATKSCSFSA
910 920 930
CTDGISWPFV LLIMPLVIWV YSTDTNFSDM FWS
Length:933
Mass (Da):102,591
Last modified:April 18, 2012 - v1
Checksum:i297F878400187DCE
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P16615AT2A2_HUMAN
Sarcoplasmic/endoplasmic reticulum ...
ATP2A2 ATP2B
1,042Annotation score:
J3QSY6J3QSY6_HUMAN
Sarcoplasmic/endoplasmic reticulum ...
ATP2A2
50Annotation score:
A0A0C4DH86A0A0C4DH86_HUMAN
Sarcoplasmic/endoplasmic reticulum ...
ATP2A2
46Annotation score:
F8W1Z7F8W1Z7_HUMAN
Sarcoplasmic/endoplasmic reticulum ...
ATP2A2
44Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006088 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000548169; ENSP00000449454; ENSG00000174437
UCSCiuc058tcn.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006088 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliH7C5W9
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiH7C5W9
PeptideAtlasiH7C5W9
PRIDEiH7C5W9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000548169; ENSP00000449454; ENSG00000174437
UCSCiuc058tcn.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000174437.16
HGNCiHGNC:812 ATP2A2
OpenTargetsiENSG00000174437
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0202 Eukaryota
COG0474 LUCA
GeneTreeiENSGT00890000139334

Miscellaneous databases

ChiTaRSiATP2A2 human

Gene expression databases

BgeeiENSG00000174437 Expressed in 244 organ(s), highest expression level in heart
ExpressionAtlasiH7C5W9 baseline and differential

Family and domain databases

Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 2 hits
InterProiView protein in InterPro
IPR006068 ATPase_P-typ_cation-transptr_C
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR005782 P-type_ATPase_IIA
IPR001757 P_typ_ATPase
PfamiView protein in Pfam
PF00689 Cation_ATPase_C, 1 hit
PRINTSiPR00120 HATPASE
SUPFAMiSSF56784 SSF56784, 1 hit
SSF81653 SSF81653, 1 hit
SSF81660 SSF81660, 1 hit
SSF81665 SSF81665, 3 hits
TIGRFAMsiTIGR01116 ATPase-IIA1_Ca, 1 hit
TIGR01494 ATPase_P-type, 2 hits
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiH7C5W9_HUMAN
AccessioniPrimary (citable) accession number: H7C5W9
Entry historyiIntegrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: September 12, 2018
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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