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Protein
Submitted name:

Peripherin

Gene

PRPH

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Submitted name:
PeripherinImported
Gene namesi
Name:PRPHImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000135406.13
HGNCiHGNC:9461 PRPH

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Intermediate filamentPROSITE-ProRule annotationSAAS annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000135406

PTM / Processingi

Proteomic databases

MaxQBiH7C5W5
PeptideAtlasiH7C5W5
PRIDEiH7C5W5

Expressioni

Gene expression databases

BgeeiENSG00000135406 Expressed in 129 organ(s), highest expression level in dorsal root ganglion
ExpressionAtlasiH7C5W5 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliH7C5W5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 136IF rodInterPro annotationAdd BLAST136

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili23 – 75Sequence analysisAdd BLAST53
Coiled coili80 – 114Sequence analysisAdd BLAST35

Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotationSAAS annotation

Keywords - Domaini

Coiled coilPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG410IE39 Eukaryota
ENOG410YCMG LUCA
GeneTreeiENSGT00910000143989

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR027700 PRPH/Plasticin
PANTHERiPTHR23239 PTHR23239, 1 hit
PTHR23239:SF29 PTHR23239:SF29, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

H7C5W5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
XESIAAKNLQ EAEEWYKSKY ADLSDAANRN HEALRQAKQE MNESRRQIQS
60 70 80 90 100
LTCEVDGLRG TNEALLRQLR ELEEQFALEA GGYQAGAARL EEELRQLKEE
110 120 130 140 150
MARHLREYQE LLNVKMALDI EIATYRKLLE GEESRISVPV HSFASLNIKT
160 170 180 190 200
TVPEVEPPQD SHSRKTVLIK TIETRNGEQV VTESQKEQRS ELDKSSAHSY
Length:200
Mass (Da):22,937
Last modified:April 18, 2012 - v1
Checksum:iC91482F99AC22F00
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P41219PERI_HUMAN
Peripherin
PRPH NEF4, PRPH1
470Annotation score:
F8W835F8W835_HUMAN
Peripherin
PRPH
207Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC125611 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000532332; ENSP00000437182; ENSG00000135406
UCSCiuc058npd.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC125611 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliH7C5W5
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiH7C5W5
PeptideAtlasiH7C5W5
PRIDEiH7C5W5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000532332; ENSP00000437182; ENSG00000135406
UCSCiuc058npd.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000135406.13
HGNCiHGNC:9461 PRPH
OpenTargetsiENSG00000135406
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IE39 Eukaryota
ENOG410YCMG LUCA
GeneTreeiENSGT00910000143989

Miscellaneous databases

ChiTaRSiPRPH human

Gene expression databases

BgeeiENSG00000135406 Expressed in 129 organ(s), highest expression level in dorsal root ganglion
ExpressionAtlasiH7C5W5 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR027700 PRPH/Plasticin
PANTHERiPTHR23239 PTHR23239, 1 hit
PTHR23239:SF29 PTHR23239:SF29, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiH7C5W5_HUMAN
AccessioniPrimary (citable) accession number: H7C5W5
Entry historyiIntegrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: September 12, 2018
This is version 45 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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