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UniProtKB - H7C5W4 (H7C5W4_HUMAN)
Protein
Submitted name:
Histone-lysine N-methyltransferase 2A
Gene
KMT2A
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- DNA binding Source: InterPro
- histone methyltransferase activity (H3-K4 specific) Source: InterPro
- zinc ion binding Source: InterPro
Keywordsi
Molecular function | DNA-bindingARBA annotation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Submitted name: Histone-lysine N-methyltransferase 2AImported |
Gene namesi | Name:KMT2AImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:7132, KMT2A |
VEuPathDBi | HostDB:ENSG00000118058 |
PTM / Processingi
Proteomic databases
MaxQBi | H7C5W4 |
PeptideAtlasi | H7C5W4 |
PRIDEi | H7C5W4 |
ProteomicsDBi | 46155 |
Expressioni
Gene expression databases
Bgeei | ENSG00000118058, Expressed in forebrain and 256 other tissues |
ExpressionAtlasi | H7C5W4, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 231 – 279 | CXXC-typeInterPro annotationAdd BLAST | 49 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 27 | DisorderedSequence analysisAdd BLAST | 27 | |
Regioni | 55 – 100 | DisorderedSequence analysisAdd BLAST | 46 | |
Regioni | 122 – 149 | DisorderedSequence analysisAdd BLAST | 28 | |
Regioni | 190 – 238 | DisorderedSequence analysisAdd BLAST | 49 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 26 | Polar residuesSequence analysisAdd BLAST | 26 | |
Compositional biasi | 130 – 145 | Polar residuesSequence analysisAdd BLAST | 16 |
Keywords - Domaini
Zinc-fingerPROSITE-ProRule annotationARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000160099 |
HOGENOMi | CLU_1040267_0_0_1 |
Family and domain databases
InterProi | View protein in InterPro IPR037927, KMT2A IPR002857, Znf_CXXC |
PANTHERi | PTHR45838:SF2, PTHR45838:SF2, 1 hit |
Pfami | View protein in Pfam PF02008, zf-CXXC, 1 hit |
PROSITEi | View protein in PROSITE PS51058, ZF_CXXC, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All
H7C5W4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
AAAASAASSS SASSSSSSSS SASSGPALLR VGPGFDAALQ VSAAIGTNLR
60 70 80 90 100
RFRAVFGESG GGGGSGEDEQ FLGFGSDEEV RVRSPTRSPS GSMLAQADKL
110 120 130 140 150
PMTDKRVASL LKKAKAQLCK IEKSKSLKQT DQPKAQGQES DSSETSVRGP
160 170 180 190 200
RIKHVCRRAA VALGRKRAVF PDDMPTLSAL PWEEREKILS SMGNDDKSSI
210 220 230 240 250
AGSEDAEPLA PPIKPIKPVT RNKAPQEPPV KKGRRSRRCG QCPGCQVPED
260 270 280 290 300
CGVCTNCLDK PKFGGRNIKK QCCKMRKCQN LQWMPSKAYL QKQAKAVKKK
EK
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ03164 | KMT2A_HUMAN | Histone-lysine N-methyltransferase ... | KMT2A ALL1, CXXC7, HRX, HTRX, MLL | 3,969 | Annotation score: | ||
E9PR05 | E9PR05_HUMAN | Histone-lysine N-methyltransferase ... | KMT2A | 1,439 | Annotation score: | ||
A0A3B3ISN4 | A0A3B3ISN4_HUMAN | Histone-lysine N-methyltransferase ... | KMT2A | 173 | Annotation score: | ||
A0A3B3ITZ6 | A0A3B3ITZ6_HUMAN | Histone-lysine N-methyltransferase ... | KMT2A | 237 | Annotation score: | ||
H7C5V8 | H7C5V8_HUMAN | Histone-lysine N-methyltransferase ... | KMT2A | 160 | Annotation score: | ||
H0YEU4 | H0YEU4_HUMAN | Histone-lysine N-methyltransferase ... | KMT2A | 87 | Annotation score: | ||
A0A3B3ITT7 | A0A3B3ITT7_HUMAN | Histone-lysine N-methyltransferase ... | KMT2A | 69 | Annotation score: | ||
A0A3B3ITT0 | A0A3B3ITT0_HUMAN | Histone-lysine N-methyltransferase ... | KMT2A | 50 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Imported | 1 | |
Non-terminal residuei | 302 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AP000941 Genomic DNA No translation available. AP001267 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000533790; ENSP00000436700; ENSG00000118058 |
UCSCi | uc001ptd.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AP000941 Genomic DNA No translation available. AP001267 Genomic DNA No translation available. |
3D structure databases
SMRi | H7C5W4 |
ModBasei | Search... |
Proteomic databases
MaxQBi | H7C5W4 |
PeptideAtlasi | H7C5W4 |
PRIDEi | H7C5W4 |
ProteomicsDBi | 46155 |
Protocols and materials databases
Antibodypediai | 18629, 460 antibodies from 35 providers |
Genome annotation databases
Ensembli | ENST00000533790; ENSP00000436700; ENSG00000118058 |
UCSCi | uc001ptd.2, human |
Organism-specific databases
HGNCi | HGNC:7132, KMT2A |
OpenTargetsi | ENSG00000118058 |
VEuPathDBi | HostDB:ENSG00000118058 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000160099 |
HOGENOMi | CLU_1040267_0_0_1 |
Miscellaneous databases
ChiTaRSi | KMT2A, human |
Gene expression databases
Bgeei | ENSG00000118058, Expressed in forebrain and 256 other tissues |
ExpressionAtlasi | H7C5W4, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR037927, KMT2A IPR002857, Znf_CXXC |
PANTHERi | PTHR45838:SF2, PTHR45838:SF2, 1 hit |
Pfami | View protein in Pfam PF02008, zf-CXXC, 1 hit |
PROSITEi | View protein in PROSITE PS51058, ZF_CXXC, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | H7C5W4_HUMAN | |
Accessioni | H7C5W4Primary (citable) accession number: H7C5W4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 18, 2012 |
Last sequence update: | December 5, 2018 | |
Last modified: | January 19, 2022 | |
This is version 65 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |