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Protein
Submitted name:

Solute carrier family 12 member 8

Gene

SLC12A8

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Solute carrier family 12 member 8Imported
Gene namesi
Name:SLC12A8Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000221955.10
HGNCiHGNC:15595 SLC12A8

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei115 – 136HelicalSequence analysisAdd BLAST22
Transmembranei148 – 171HelicalSequence analysisAdd BLAST24
Transmembranei183 – 204HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000221955

PTM / Processingi

Proteomic databases

PRIDEiH7C5L2

Expressioni

Gene expression databases

BgeeiENSG00000221955 Expressed in 155 organ(s), highest expression level in right lobe of thyroid gland
ExpressionAtlasiH7C5L2 baseline and differential

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini92 – 201AA_permeaseInterPro annotationAdd BLAST110

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG2083 Eukaryota
COG0531 LUCA
GeneTreeiENSGT00760000119053

Family and domain databases

InterProiView protein in InterPro
IPR004841 AA-permease/SLC12A_dom
PfamiView protein in Pfam
PF00324 AA_permease, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

H7C5L2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
LGWCVHILHD QHLWGCALPE DWLAGGKHRS APGHVPGVLR HPGGPRHGAV
60 70 80 90 100
WHWRRGAQQH RQRWRLLHDL LGPGWADGRH HRAALCVWTE HGFIGYSPEL
110 120 130 140 150
LQNNTLPDYS PGESFFTVFG VFFPAATGVM AGFNMGGDLR EPAASIPLGS
160 170 180 190 200
LAAVGISWFL YIIFVFLLGA ICTREALRYD FLIAEKVSLM GFLFLLGLYI

SSLASCM
Length:207
Mass (Da):22,966
Last modified:October 29, 2014 - v2
Checksum:i8B8831011784016C
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0AV02S12A8_HUMAN
Solute carrier family 12 member 8
SLC12A8 CCC9
714Annotation score:
C9IZN2C9IZN2_HUMAN
Solute carrier family 12 member 8
SLC12A8
112Annotation score:
H7C5B1H7C5B1_HUMAN
Solute carrier family 12 member 8
SLC12A8
160Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1
Non-terminal residuei207Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC055752 Genomic DNA No translation available.
AC108688 Genomic DNA No translation available.
AC117488 Genomic DNA No translation available.
KF459585 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000479826; ENSP00000420197; ENSG00000221955
UCSCiuc062ngw.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC055752 Genomic DNA No translation available.
AC108688 Genomic DNA No translation available.
AC117488 Genomic DNA No translation available.
KF459585 Genomic DNA No translation available.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiH7C5L2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000479826; ENSP00000420197; ENSG00000221955
UCSCiuc062ngw.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000221955.10
HGNCiHGNC:15595 SLC12A8
OpenTargetsiENSG00000221955
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2083 Eukaryota
COG0531 LUCA
GeneTreeiENSGT00760000119053

Miscellaneous databases

ChiTaRSiSLC12A8 human

Gene expression databases

BgeeiENSG00000221955 Expressed in 155 organ(s), highest expression level in right lobe of thyroid gland
ExpressionAtlasiH7C5L2 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR004841 AA-permease/SLC12A_dom
PfamiView protein in Pfam
PF00324 AA_permease, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiH7C5L2_HUMAN
AccessioniPrimary (citable) accession number: H7C5L2
Entry historyiIntegrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: October 29, 2014
Last modified: September 12, 2018
This is version 35 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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