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Protein
Submitted name:

Dynein heavy chain 1, axonemal

Gene

DNAH1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Dynein heavy chain 1, axonemalImported
Gene namesi
Name:DNAH1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000114841.17
HGNCiHGNC:2940 DNAH1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000114841

PTM / Processingi

Proteomic databases

PeptideAtlasiH7C563
PRIDEiH7C563

Expressioni

Gene expression databases

BgeeiENSG00000114841 Expressed in 128 organ(s), highest expression level in right uterine tube
ExpressionAtlasiH7C563 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliH7C563
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 75MTInterPro annotationAdd BLAST64
Domaini105 – 325AAA_9InterPro annotationAdd BLAST221
Domaini463 – 889Dynein_heavyInterPro annotationAdd BLAST427

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili2 – 22Sequence analysisAdd BLAST21
Coiled coili269 – 293Sequence analysisAdd BLAST25
Coiled coili315 – 335Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG3595 Eukaryota
COG5245 LUCA
GeneTreeiENSGT00760000118964

Family and domain databases

InterProiView protein in InterPro
IPR035706 DHC_D5
IPR026983 DHC_fam
IPR026975 DNAH1
IPR024743 Dynein_HC_stalk
IPR004273 Dynein_heavy_dom
PANTHERiPTHR10676 PTHR10676, 1 hit
PTHR10676:SF358 PTHR10676:SF358, 1 hit
PfamiView protein in Pfam
PF12781 AAA_9, 1 hit
PF03028 Dynein_heavy, 1 hit
PF12777 MT, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

H7C563-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
KKEELELKCE QCEQRLGRAG KLINGLSDEK VRWQETVENL QYMLNNISGD
60 70 80 90 100
VLVAAGFVAY LGPFTGQYRT VLYDSWVKQL RSHNVPHTSE PTLIGTLGNP
110 120 130 140 150
VKIRSWQIAG LPNDTLSVEN GVINQFSQRW THFIDPQSQA NKWIKNMEKD
160 170 180 190 200
NGLDVFKLSD RDFLRSMENA IRFGKPCLLE NVGEELDPAL EPVLLKQTYK
210 220 230 240 250
QQGNTVLKLG DTVIPYHEDF RMYITTKLPN PHYTPEISTK LTLINFTLSP
260 270 280 290 300
SGLEDQLLGQ VVAEERPDLE EAKNQLIISN AKMRQELKDI EDQILYRLSS
310 320 330 340 350
SEGNPVDDME LIKVLEASKM KAAEIQAKVR IAEQTEKDID LTRMEYIPVA
360 370 380 390 400
IRTQILFFCV SDLANVDPMY QYSLEWFLNI FLSGIANSER ADNLKKRISN
410 420 430 440 450
INRYLTYSLY SNVCRSLFEK HKLMFAFLLC VRIMMNEGKI NQSEWRYLLS
460 470 480 490 500
GGSISIMTEN PAPDWLSDRA WRDILALSNL PTFSSFSSDF VKHLSEFRVI
510 520 530 540 550
FDSLEPHREP LPGIWDQYLD QFQKLLVLRC LRGDKVTNAM QDFVATNLEP
560 570 580 590 600
RFIEPQTANL SVVFKDSNST TPLIFVLSPG TDPAADLYKF AEEMKFSKKL
610 620 630 640 650
SAISLGQGQG PRAEAMMRSS IERGKWVFFQ NCHLAPSWMP ALERLIEHIN
660 670 680 690 700
PDKVHRDFRL WLTSLPSNKF PVSILQNGSK MTIEPPRGVR ANLLKSYSSL
710 720 730 740 750
GEDFLNSCHK VMEFKSLLLS LCLFHGNALE RRKFGPLGFN IPYEFTDGDL
760 770 780 790 800
RICISQLKMF LDEYDDIPYK VLKYTAGEIN YGGRVTDDWD RRCIMNILED
810 820 830 840 850
FYNPDVLSPE HSYSASGIYH QIPPTYDLHG YLSYIKSLPL NDMPEIFGLH
860 870 880 890 900
DNANITFAQN ETFALLGTII QLQPKSSSAG SQGREEVQSA AAGDHTDTAR
910 920
PTQGTQGAGS DVLSAGADGC QPVQQYCA
Length:928
Mass (Da):105,442
Last modified:October 29, 2014 - v2
Checksum:iE55C977C31E2F15F
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9P2D7DYH1_HUMAN
Dynein heavy chain 1, axonemal
DNAH1 DHC7, DNAHC1, KIAA1410
4,265Annotation score:
H7C506H7C506_HUMAN
Dynein heavy chain 1, axonemal
DNAH1
193Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC092045 Genomic DNA No translation available.
KF459588 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000490713; ENSP00000419071; ENSG00000114841
UCSCiuc062klk.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC092045 Genomic DNA No translation available.
KF459588 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliH7C563
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiH7C563
PRIDEiH7C563

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000490713; ENSP00000419071; ENSG00000114841
UCSCiuc062klk.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000114841.17
HGNCiHGNC:2940 DNAH1
OpenTargetsiENSG00000114841
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3595 Eukaryota
COG5245 LUCA
GeneTreeiENSGT00760000118964

Miscellaneous databases

ChiTaRSiDNAH1 human

Gene expression databases

BgeeiENSG00000114841 Expressed in 128 organ(s), highest expression level in right uterine tube
ExpressionAtlasiH7C563 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR035706 DHC_D5
IPR026983 DHC_fam
IPR026975 DNAH1
IPR024743 Dynein_HC_stalk
IPR004273 Dynein_heavy_dom
PANTHERiPTHR10676 PTHR10676, 1 hit
PTHR10676:SF358 PTHR10676:SF358, 1 hit
PfamiView protein in Pfam
PF12781 AAA_9, 1 hit
PF03028 Dynein_heavy, 1 hit
PF12777 MT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiH7C563_HUMAN
AccessioniPrimary (citable) accession number: H7C563
Entry historyiIntegrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: October 29, 2014
Last modified: September 12, 2018
This is version 51 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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