UniProtKB - H7C4S4 (H7C4S4_HUMAN)
Protein
Submitted name:
Fragile X mental retardation syndrome-related protein 1
Gene
FXR1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- mRNA binding Source: InterPro
GO - Biological processi
- regulation of translation Source: InterPro
Names & Taxonomyi
Protein namesi | Submitted name: Fragile X mental retardation syndrome-related protein 1Imported |
Gene namesi | Name:FXR1Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:4023, FXR1 |
VEuPathDBi | HostDB:ENSG00000114416.17 |
Subcellular locationi
Cytosol
- cytosol Source: HPA
Expressioni
Gene expression databases
Bgeei | ENSG00000114416, Expressed in testis and 245 other tissues |
ExpressionAtlasi | H7C4S4, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 2 – 57 | FXMRP1_C_coreInterPro annotationAdd BLAST | 56 | |
Domaini | 61 – 135 | FXR_C1InterPro annotationAdd BLAST | 75 | |
Domaini | 182 – 246 | FXR_C3InterPro annotationAdd BLAST | 65 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 246 | DisorderedSequence analysisAdd BLAST | 246 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 10 – 45 | PolyampholyteSequence analysisAdd BLAST | 36 | |
Compositional biasi | 68 – 90 | PolarSequence analysisAdd BLAST | 23 | |
Compositional biasi | 168 – 182 | PolarSequence analysisAdd BLAST | 15 | |
Compositional biasi | 183 – 203 | PolyampholyteSequence analysisAdd BLAST | 21 | |
Compositional biasi | 222 – 236 | PolyampholyteSequence analysisAdd BLAST | 15 |
Phylogenomic databases
GeneTreei | ENSGT00950000183189 |
HOGENOMi | CLU_083199_0_0_1 |
Family and domain databases
InterProi | View protein in InterPro IPR040148, FMR1 IPR022034, FXMRP1_C_core IPR032172, FXR_C1 IPR032177, FXR_C3 |
PANTHERi | PTHR10603, PTHR10603, 1 hit |
Pfami | View protein in Pfam PF12235, FXMRP1_C_core, 1 hit PF16096, FXR_C1, 1 hit PF16097, FXR_C3, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 10 potential isoforms that are computationally mapped.Show allAlign All
H7C4S4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
XTNSELSNPS ETESERKDEL SDWSLAGEDD RDSRHQRDSR RRPGGRGRSV
60 70 80 90 100
SGGRGRGGPR GGKSSISSVL KDPDSNPYSL LDNTESDQTA DTDASESHHS
110 120 130 140 150
TNRRRRSRRR RTDEDAVLMD GMTESDTASV NENGLDDSEK KPQRRNRSRR
160 170 180 190 200
RRFRGQAEDR QPVTVADYIS RAESQSRQRN LPRETLAKNK KEMAKDVIEE
210 220 230 240
HGPSEKAING PTSASGDDIS KLQRTPGEEK INTLKEENTQ EAAVLN
Computationally mapped potential isoform sequencesi
There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP51114 | FXR1_HUMAN | Fragile X mental retardation syndro... | FXR1 | 621 | Annotation score: | ||
B4DXZ6 | B4DXZ6_HUMAN | Fragile X mental retardation syndro... | FXR1 | 608 | Annotation score: | ||
E7EU85 | E7EU85_HUMAN | Fragile X mental retardation syndro... | FXR1 | 454 | Annotation score: | ||
E9PFF5 | E9PFF5_HUMAN | Fragile X mental retardation syndro... | FXR1 | 490 | Annotation score: | ||
C9JAJ4 | C9JAJ4_HUMAN | Fragile X mental retardation syndro... | FXR1 | 151 | Annotation score: | ||
C9JY20 | C9JY20_HUMAN | Fragile X mental retardation syndro... | FXR1 | 123 | Annotation score: | ||
C9IZ22 | C9IZ22_HUMAN | Fragile X mental retardation syndro... | FXR1 | 94 | Annotation score: | ||
C9J5B4 | C9J5B4_HUMAN | Fragile X mental retardation syndro... | FXR1 | 75 | Annotation score: | ||
C9JZE0 | C9JZE0_HUMAN | Fragile X mental retardation syndro... | FXR1 | 119 | Annotation score: | ||
C9JYQ6 | C9JYQ6_HUMAN | Fragile X mental retardation syndro... | FXR1 | 19 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Imported | 1 | |
Non-terminal residuei | 246 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC008009 Genomic DNA No translation available. AC068638 Genomic DNA No translation available. AC108734 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000482125; ENSP00000418027; ENSG00000114416 |
UCSCi | uc062qic.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC008009 Genomic DNA No translation available. AC068638 Genomic DNA No translation available. AC108734 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
Protein-protein interaction databases
IntActi | H7C4S4, 8 interactors |
Proteomic databases
EPDi | H7C4S4 |
PeptideAtlasi | H7C4S4 |
PRIDEi | H7C4S4 |
ProteomicsDBi | 45774 |
Protocols and materials databases
Antibodypediai | 18845, 331 antibodies |
Genome annotation databases
Ensembli | ENST00000482125; ENSP00000418027; ENSG00000114416 |
UCSCi | uc062qic.1, human |
Organism-specific databases
HGNCi | HGNC:4023, FXR1 |
OpenTargetsi | ENSG00000114416 |
VEuPathDBi | HostDB:ENSG00000114416.17 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00950000183189 |
HOGENOMi | CLU_083199_0_0_1 |
Miscellaneous databases
ChiTaRSi | FXR1, human |
Gene expression databases
Bgeei | ENSG00000114416, Expressed in testis and 245 other tissues |
ExpressionAtlasi | H7C4S4, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR040148, FMR1 IPR022034, FXMRP1_C_core IPR032172, FXR_C1 IPR032177, FXR_C3 |
PANTHERi | PTHR10603, PTHR10603, 1 hit |
Pfami | View protein in Pfam PF12235, FXMRP1_C_core, 1 hit PF16096, FXR_C1, 1 hit PF16097, FXR_C3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | H7C4S4_HUMAN | |
Accessioni | H7C4S4Primary (citable) accession number: H7C4S4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 18, 2012 |
Last sequence update: | October 5, 2016 | |
Last modified: | February 10, 2021 | |
This is version 60 of the entry and version 8 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |